Developed new approaches for gene based therapies of both inherited and acquired diseases. My current focus is on inherited liver diseases. Validation of gene therapy approaches is performed routinely on three animal models: the Gunn Rat (model for Crigler-Najjar syndrome type 1), Mps VII mice (model for Sly syndrome) and Agxt-/-mice (model for primary hyperoxaluria-1). In addition, I routinely apply my experience in generating gene transfer vectors for research on pathophysiological mechanisms, as well as development of novel therapies. I work specifically on vectors base on recombinant adenoviruses, lentiviruses and SV40 viruses. In addition, I have been involved in developing non-viral gene transfer techniques.