Selected Recent Publications (Complete publications at PubMed: Goldman ID)
Zhao R, Unal E, Shin D, Goldman ID. Membrane topological analyses of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method. Biochemistry 49:2925-2931, 2010. PMCID:PMC2866095
Shin DS, Min SH, Russell L, Zhao R, Fiser A and Goldman ID. Functional roles of aspartate residues of the human proton-coupled folate transporter (PCFT; SLC46A1); D156, mutated in hereditary folate malabsorption, is critical for protein stability; D109 is irreplaceable. Blood116:5162-9, 2010. PMCID:PMC3012536
Mahadeo K, Bove-Diop N, Ramirez S, Cadilla CL, Rivera E, Martin M, Lerner N B,Santiago-Borrero BJ, and Goldman ID. Prevalence of a loss-of-function founder mutation in the Proton-Coupled Folate Transporter Gene (PCFT-SLC46A1) causing Hereditary Folate Malabsorption in Puerto Rico. J. Pediatrics. 159:623-627,2011. PMCID:PMC3935241.
Zhao R, Shin DS, Diop-Bove N, Ovits CG and Goldman ID Random mutagenesis of the proton-coupled folate transporter (PCFT, SLC46A1), clustering of base deletion/insertion mutations and mechanisms underlying loss-of-function mutations. J. Biol. Chem. 286:24150-8, 2011 PMCID: PMC3129196
Shin DS, Zhao R, Yap EH, Fiser A, Goldman ID. A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. Am. J. of Physiol., Cell Physiol. 302:C1405-12, 2012. PMCID: PMC3361945
Visentin M, Zhao R, Goldman ID. Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate. Mol Pharmacol. 82:209-16, 2012. PMCID:PMC3400841
Shin DS, Zhao R, Fiser A Goldman ID. The role of the fourth transmembrane domain in proton-coupled folate transporter (PCFT-SLC46A1) function as assessed by the substituted cysteine accessibility method. Am J Physiol. Cell Physiol. 304:C1159-67, 2013. PMCID:PMC3680650
Zhao R, Diop-Bove N, Goldman ID, Enhanced Receptor-mediated Endocytosis and Cytotoxicity of a Folic Acid-desacetylvinblastine Monohydrazide Conjugate in a Pemetrexed-Resistant Cell Line Lacking Folate-specific Facilitative Carriers but with Increased Folate Receptor Expression. Mol. Pharmacol. 85:310-21, 2014. PMCID: PMC3913358.
Visentin M, Unal ES, Najmi M, Fiser A, Zhao R, Goldman ID. Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). Am J Physiol Cell Physiol. 308:C631-41, 2015. PMCID: PMC4398847.
Recent Reviews from this laboratory
Zhao, R., Matherly, LH., and Goldman ID. Membrane transporters and folate homeostasis: Intestinal absorption, transport into systemic compartments and tissues. Expert Reviews in Molecular Medicine, Cambridge University Press, ePub 11:E4, 2009.
Goldman ID, Chattopadhyay S and Moran R. The Antifolates: Evolution, New Agents in the Clinic, and How Targeting Delivery via Specific Membrane Transporters is Driving Development of a Next Generation of Folate Analogs. Current Opinion in Investigational Drugs. 11:1409-23, 2010.
Zhao R, Diop-Bove N, Visentin M, and Goldman ID. Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia. Annual Review of Nutrition. 31:177-201, 2011.
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 34:373-85, 2013.
Visentin M, Diop-Bove N, Zhao R, Goldman ID. The Intestinal Absorption of Folates. Ann Rev of Physiol. 76:251-74, 2014. PMCID:PMC 3982215.
Diop-Bove N, Kronn D, Goldman ID. Hereditary Folate Malabsorption. 2008 Jun 17 [Updated 2014 Jun 5]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2014. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1673/