Selected recent publications:
M Bujak, G Ren, HJ Kweon, M Dobaczewski, A Reddy, G Taffet, XF Wang, and NG Frangogiannis. Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling. Circulation 2007; 116:2127-38.
P Huebener, T Abou-Khamis, P Zymek, M Bujak, Ying X, K Chatila, S Haudek, G Thakker, and NG Frangogiannis, CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol 2008; 180:2625-33.
M Bujak, HJ Kweon, K Chatila, N Li, G Taffet, and NG Frangogiannis. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol 2008; 51:1384-92.
M Bujak, M Dobaczewski, K Chatila, L Mendoza, N Li, A Reddy, and NG Frangogiannis. Interleukin-1 type (IL-1RI) signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 2008; 173:57-67.
M Bujak, M Dobaczewski, C Gonzalez-Quesada, Y Xia, T Leucker, P Zymek, V Veeranna, A Tager, A Luster, and NG Frangogiannis. Induction of the CXC Chemokine Interferon-g-Inducible Protein (IP)-10 Regulates the Reparative Response Following Myocardial Infarction. Circ Res 2009; 105:973-83.
M Dobaczewski, Y Xia, M Bujak, C Gonzalez-Quesada, and NG Frangogiannis. CCR5 signaling suppresses inflammation and reduces adverse remodeling following myocardial infarction mediating recruitment of regulatory T cells. Am J Pathol 2010; 176: 2177-87.
M Dobaczewski, M Bujak, N Li, C Gonzalez-Quesada; LH Mendoza, XF Wang, and NG Frangogiannis. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res 2010; 107 (3): 418-28.
M Dobaczewski, W Chen and NG Frangogiannis. Transforming Growth Factor (TGF)-beta signaling in cardiac remodeling. J Mol Cell Cardiol 2011; 51:600-606.
NG Frangogiannis. The SDF-1/CXCR4 axis in cardiac injury and repair. J Am Coll Cardiol 2011; 58: 2424-2426.
Y Xia, M Dobaczewski, C Gonzalez-Quesada, W Chen, A Biernacka, N Li, D Lee, and NG Frangogiannis. Endogenous Thrombospondin-1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension 2011; 58: 902-911.
NG Frangogiannis. Regulation of the inflammatory response in cardiac repair. Circ Res 2012: 110: 159-173.
NG Frangogiannis. Matricellular proteins in cardiac adaptation and disease. Physiol Rev 2012; 92:635-688.
W Chen, A Saxena, N Li, J Sun, DW Lee, Q Tian, M Dobaczewski, and NG Frangogiannis. Endogenous IRAK-M attenuates post-infarction remodeling through effects on macrophages and fibroblasts. Arterioscl Thromb Vasc Biol 2012; 32:2598-608.
W Chen and NG Frangogiannis. Fibroblasts in post-infarction inflammation and cardiac repair. BBA Mol Basis Dis. 2013; 1833:945-53
P Christia, M Bujak, C Gonzalez-Quesada, W Chen, M Dobaczewski, A Reddy, and NG Frangogiannis. Systematic characterization of myocardial inflammation, repair and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem 2013; 61:555-570.
P Christia, and NG Frangogiannis. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest 2013; 43: 986-95.
P Kong, C Gonzalez-Quesada, N Li, M Cavalera, D-W Lee, and NG Frangogiannis. Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab 2013; 305:E439-450.
P Kong, P Christia, A Saxena, Y Su, and NG Frangogiannis. Lack of specificity of Fibroblast Specific Protein (FSP)1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol 2013;305(9):H1363-72.
A Saxena, W Chen, Y Su, V Rai, OU Uche, N Li, and NG Frangogiannis. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol 2013; 191(9):4838-48.
C Gonzalez-Quesada, M Cavalera, A Biernacka, P Kong, DW Lee, A Saxena, O Frunza, M Dobaczewski, AV Shinde, and NG Frangogiannis. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix while promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res 2013; 113(12):1331-44.
P Kong, P Christia, and NG Frangogiannis. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci 2014 ; 71: 549-574.
AV Shinde and NG Frangogiannis. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 2014; 70:74-82.
NG Frangogiannis. The inflammatory response in myocardial injury, repair and remodeling. Nat Rev Cardiol 2014; 11:255-265.
A Saxena, M Bujak, O Frunza, M Dobaczewski, C Gonzalez-Quesada, B Lu, C Gerard, and NG Frangogiannis. CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans. Cardiovasc Res 2014; 103:217-227.
M Cavalera, J Wang, and NG Frangogiannis. Obesity, metabolic dysfunction and cardiac fibrosis: pathophysiologic pathways, molecular mechanisms and therapeutic opportunities. Transl Res 2014; 164:323-335.
A Saxena, M Dobaczewski, V Rai, Z Haque, W Chen, N Li, and NG Frangogiannis. Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function. Am J Physiol Heart Circ Physiol 2014; 307(8):H1233-42.
NG Frangogiannis. The pathophysiology of myocardial infarction. Compr Physiol 2015; 5:1841-75.
AV Shinde and NG Frangogiannis. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium Circ Res 2015; 117:10-12.
A Biernacka, M Cavalera, J Wang, I Russo, A Shinde, P Kong, C Gonzalez-Quesada, V Rai, M Dobaczewski, DW Lee, XF Wang, and NG Frangogiannis. Smad3 signaling promotes fibrosis, while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail 2015; 8: 788-798.
A Saxena, AV Shinde, Z Haque, YJ Wu, W Chen, Y Su, and NG Frangogiannis. The role of Interleukin receptor associated kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction. J Mol Cell Cardiol 2015; 89: 223-31.
NG Frangogiannis. The reparative function of cardiomyocytes in the infarcted myocardium Cell Metab 2015; 21: 797-798.
NG Frangogiannis. Emerging roles for macrophages in cardiac injury: cytoprotection, repair and regeneration J Clin Invest 2015; 125: 2927-30.
I Russo, and NG Frangogiannis. Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol 2016; 90:84-93.
A Saxena, I Russo, and NG Frangogiannis. Inflammation as a therapeutic target in myocardial infarction:learning from past failures to meet future challenges. Transl Res 2016; 167:152-66.
O Frunza, I Russo, A Saxena, AV Shinde, C Humeres, W Hanif, V Rai, Y Su, and NG Frangogiannis. Myocardial galectin-3 expression is associated with remodeling of the pressure-overloaded heart and may delay the hypertrophic response, without affecting survival, dysfunction, and cardiac fibrosis. Am J Pathol 2016; 186:1114-27.
NG Frangogiannis. Fibroblast-extracellular matrix interactions in tissue fibrosis. Curr Pathobiol Rep 2016; 1:11-18.
S Prabhu, and NG Frangogiannis. The cell biological basis of cardiac repair: from inflammation to fibrosis. Circ Res 2016: 119:91-112.
B Chen, and NG Frangogiannis. Macrophages in the remodeling failing heart. Circ Res 2016; 119: 776-778.
FG Spinale, NG Frangogiannis, B Hinz, JW Holmes, Z Kassiri, ML Lindsey. Crossing into the next frontier of cardiac extracellular matrix research. Circ Res 2016; 119: 1040-1045.
NG Frangogiannis. The functional pluralism of fibroblasts in the infarcted myocardium. Circ Res 2016; 119: 1049-1051.
B Chen, and NG Frangogiannis. Immune cells in repair of the infarcted myocardium. Microcirculation 2017 Jan;24(1). doi: 10.1111/micc.12305.
AV Shinde, C Humeres, and NG Frangogiannis. The role of alpha-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. BBA Mol Bas Dis 2017; 1863: 298-309.
Frangogiannis NG. The role of transforming growth factor (TGF)-b in the infarcted myocardium. J Thoracic Dis 2017; 9(Suppl 1): S52-S63.
NG Frangogiannis. The extracellular matrix in myocardial injury, repair and remodeling. J Clin Invest 2017; 127: 1600-1612.
W Hanif, L Alex, Y Su, AV Shinde, I Russo, N Li, and NG Frangogiannis. Left atrial remodeling, hypertrophy and fibrosis in mouse models of heart failure. Cardiovasc Pathol 2017;30-27-37.
AV Shinde, M Dobaczewski, JJ De Haan, A Saxena, KK Lee, Y Xia, W Chen, Y Su, W Hanif, IK Madahar, VM Paulino, G Melino and NG Frangogiannis. Tissue transglutaminase induction in the pressure-overloaded myocardium regulates cardiac remodeling. Cardiovasc Res 2017; 113:892-905.
Y Wang, B Wu, P Lu, D Zhang, B Wu, S Varshney, G Del Monte-Nieto, Z Zhuang, R Charafeddine, AH Kramer, NE Sibinga, NG Frangogiannis, RN Kitsis, RH Adams, K Alitalo, DJ Sharp, RP Harvey, P Stanley, and B Zhou. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun 2017 Sep 18;8(1):578. doi: 10.1038/s41467-017-00654-w.
AV Shinde and NG Frangogiannis. Mechanisms of fibroblast activation in the remodeling myocardium. Curr Pathobiol Rep 2017; 5:145-152.
NG Frangogiannis. Activation of the innate immune system in the pathogenesis of acute heart failure. Eur Heart J Acute Cardiovasc Care 2017 2017 Apr 1:2048872617707456. doi: 10.1177/2048872617707456.
NG Frangogiannis. Fibroblasts and the extracellular matrix in right ventricular disease. Cardiovasc Res 2017; 113:1453-1464..
AV Shinde and NG Frangogiannis. Tissue transglutaminase in the pathogenesis of heart failure. Cell Death Differentiation 2017 Dec 13. doi: 10.1038/s41418-017-0028-9 (epub ahead of print).
P Kong, A Shinde, Y Su, I Russo, B Chen, A Saxena, SJ Conway, JM Graff and NG Frangogiannis. Opposing actions of fibroblast and cardiomyocyte Smad3 signaling in the infarcted myocardium. Circulation 2018 Feb 13;137(7):707-724.
S Huang, and NG Frangogiannis. Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges. Br J Pharmacol 2018 Feb 2. doi: 10.1111/bph.14155 (epub ahead of print).
L Alex and NG Frangogiannis. The cellular origin of activated fibroblasts in the infarcted and remodeling myocardium. Circ Res 2018 Feb 16;122(4):540-542.
NG Frangogiannis. Cell therapy for peripheral artery disease. Curr Opin Pharmacol 2018; Feb 13;39:27-34.
NG Frangogiannis. Cell biological mechanisms in regulation of the post-infarction inflammatory response. Curr Opin Physiol 2018; 1: 7-13.
AV Shinde, Y Su, BA Palanski, K Fujikura, MJ Garcia, and NG Frangogiannis. Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload. J Mol Cell Cardiol 2018; 117: 36-48.
L Alex, I Russo, V Holoborodko, and NG Frangogiannis. Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human Heart Failure with Preserved Ejection Fraction. Am J Physiol Heart Circ Physiol 2018; 315:H934-949.
NG Frangogiannis. Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Asp Med 2019; 65:70-99.
NG Frangogiannis. Protean functions and phenotypic plasticity of regulatory T cells (Tregs) in chronic ischemic heart failure. Circulation 2019; 139:222-225.
B Chen, A Brickshawana, and NG Frangogiannis. The functional heterogeneity of resident cardiac macrophages in myocardial injury. CCR2+ cells promote inflammation, whereas CCR2- cells protect. Circ Res 2019; 124:183-185.
I Russo, M Cavalera, S Huang, Y Su, A Hanna, B Chen, AV Shinde, SJ Conway, JM Graff, and NG Frangogiannis.Protective effects of activated myofibroblasts in the pressure-overloaded myocardium are mediated through Smad-dependent activation of a matrix-preserving program. Circ Res 2019; 124: 1214-1227.
S Huang, B Chen, Y Su, L Alex, C Humeres, AV Shinde, SJ Conway, and NG Frangogiannis. Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart. J Mol Cell Cardiol 2019; 132:84-97.
NG Frangogiannis. Can myocardial fibrosis be reversed? J Am Coll Cardiol 2019; 73: 2283-2285.
B Chen, S Huang, Y Su, Y-J Wu, A Hanna, A Brickshawana, JM Graff, and NG Frangogiannis. Macrophage Smad3 protects the infarcted heart, stimulating phagocytosis and regulating inflammation.Circ Res 2019; 125: 55-70.
NG Frangogiannis. The extracellular matrix in heart failure. Circ Res 2019; 125: 117-146.