My research focuses on engineering of natural photoreceptors into fluorescent proteins, biosensors, and optogenetic tools. I am specifically interested in design of genetically encoded optical tools allowing non-invasive detection and activation of biological processes with deeply penetrating near-infrared light. Our near-infrared spectrally distinct proteins iRFPs have been applied to imaging of various cell types, tissues and animal models in basic and translational research, including cancer and stem cell studies, neuroscience, and parasitology. These probes enable multiple in vivo imaging modalities, from simple planar epifluorescence to tomographic and photoacoustic technologies. We are currently developing the next generation of iRFPs that will allow non-invasive visualization of molecular processes.