My research was focused on exploring the molecular mechanism of aging. Especially the role of IGF-1 signaling — There is a clear link between aging and metabolism across species. growth factors and body size have been closely tied to lifespan. This phenomenon is believed to be attributed to a reduction in growth hormone (GH)/insulin-like growth factor-1 (IGF-1) signaling, and less signaling through this axis has been has been linked to improved longevity in model organisms. Furthermore, in humans, high IGF-1 levels are associated with increased cancer risk, but are paradoxically linked with protection from cardiovascular disease, type 2 diabetes and osteoporosis. Thus, the relevance of IGF-1 to aging in humans remains unclear. My research utilizes genetically modified rodent model to study the molecular mechanism of igf-1 anti-aging effect.