Our previous research work focused on the studies of spermatogenesis and the development of new methodologies using flow cytometry and confocal microscopy for monitoring germ cell progression and to distinguish between normal and abnormal spermatogenesis.
Current research project in my group focuses on the characterization of the role of novel small proteins known as SUMO (small-ubiquitin-related modifiers) in testicular cells. Sumoylation has been identified as an important regulatory event that is implicated in several cellular processes, seemingly based on the cell type. Recent findings from our laboratory suggest diverse and potentially multiple roles of SUMO in testicular function and spermatogenesis. We have identified targets of sumoylation in testicular cells and sperm and now focus on characterization of specific targets and on the cross-talk between sumoylation and phosphorylation.
Another area of interest is an effct on tobacco smoke on reproduction and cell cycle regulation in germ cells and lungs.