Department of Pathology

Research Opportunities

 GI/Liver Pathology

The Gastrointestinal/Liver Pathology Service within the section of Surgical Pathology is dedicated to providing cutting-edge diagnosis, educating and training residents and fellows, and performing translational and basic research. The GI/Liver Pathology team works closely with clinicians and researchers in the Montefiore Pediatric and Adult Gastroenterology and Hepatology divisions, the Liver Transplantation Service, and the Marion Bessin Liver Research Center at Albert Einstein College of Medicine. Because of Montefiore Einstein's strong commitment to excellence in GI/Liver patient care and research, there are ample clinical specimens (approximately 25,000 GI/Liver biopsy cases and resections per year) to support these efforts, as well as ample opportunities for collaboration with world-class researchers.

 Hematology

The Hematology, Advanced Coagulation and Protein Separation Laboratories provide state-of-the-art testing for general screening and diagnostic evaluation of patients with blood abnormalities. The laboratories also perform more complex tests that are used to evaluate patients with coagulation disorders, plasma cell dyscrasias, and hemoglobin-opathies, as well as hematology tests.

Our goal is to provide the resident with a solid knowledge base about how all of these tests are performed and interpreted; how clinicians use – and sometimes misuse – these tests; how to communicate results and advice in a way that best serves the patient; how to manage a clinical laboratory; how to think about the tests we perform in a critical and innovate manner; and how to implement new tests. 

Following the lab rotation, the educational experience is solidified through direct exposure to patients in the Clinical Hematology Consult Service at Montefiore Medical Center.  There, the resident will work with the hematology team and gain firsthand experience in evaluating patients with hematologic complications. 

 Microbiology

The Microbiology Laboratory of Montefiore Medical Center is a division within the Department of Pathology. The laboratory is responsible for the delivery of the highest level of microbiological and immunological diagnostic services required by the clinicians of Montefiore Medical Center for the diagnosis of infectious diseases and related syndromes.

Microbiology is divided into the following areas: Bacteriology, Mycobacteriology, Mycology, Parasitology, Susceptibility Testing and Serology. The laboratory operates 24 hours a day, seven days a week, throughout the year. The Microbiology staff consists of approximately 50 full-time employees, including five supervisors and two doctoral-level, Board-certified directors.

 Molecular Pathology

The Molecular Pathology rotation is designed to provide the Pathology resident with the basic knowledge of the principles of molecular biology/genetics and applications of molecular techniques to clinical laboratory testing. It covers nucleic acid basics, isolation of nucleic acids, Southern blot analysis, PCR, reverse transcription, real-time PCR, fragment analysis, capillary and gel electrophoresis, melting curve, DNA sequencing, array CGH (comparative genomic hybridization), microarray, assay design, QA/QC issues, interpretation, troubleshooting, etc. The rotation provides hand-on experience. A short and publishable clinical research project is encouraged.

 Virology

The Virology Laboratory at Montefiore Medical Center is a full-service state-of-the-art facility. Testing for viral diseases includes HIV molecular-based assays, immunodiagnostics as well as a tissue-culture laboratory. It is one of the few hospital-based laboratories that maintains a tissue culture for the primary isolation of viruses and serves as a satellite lab for the World Health Organization and referral lab for the Centers for Disease Control and Prevention. While rotating through the Virology Laboratory, Pathology residents and Infectious Diseases fellows are offered an opportunity to engage in ongoing research or in a project of their own design. Dr. Amy Fox, Virology Laboratory Director, has developed and hosts an annual seminar in viral diagnosis for Pathology residents and fellows at which the latest material in viral diagnosis is presented. 

The laboratory is involved in the development and assessment of new molecular and serologic assays as well post-market evaluations in unique patient populations. In addition, the laboratory has hosted undergraduates participating in the Summer Undergraduate Research Program of the Albert Einstein College of Medicine. That work includes projects involving sensitivity of HIV assays, diagnostics for swine influenza and new diagnostic methods for chlamydia trachomatis. 

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