Forchheimer Building 223
Associate Professor, Department of Molecular Pharmacology
The long term goal of this research program is to understand the molecular basis of cellular machinery and their relationships to human diseases. A branch of the laboratory focuses on elucidating the interplays between transcription factors and signaling pathways. We ask how does extracellular stimuli communicate with intracellular effectors, and eventually modulate cellular responses in normal and diseased states. For example, we have recently demonstrated that adipokine gene expression mediated by transcription factor NFAT contributes to insulin and glucose homeostasis via a non-cell autonomous mechanism. We have further found that upstream regulators and downstream effectors of the NFAT transcription factor impinge on adipocyte biology at multiple levels, including novel crosstalk with G-protein coupled/cAMP signal trasduction via phospho-dependent protein degradation.
Another branch of the laboratory examines intercellular trafficking and its role in demyelinating neuropathy. A range of biochemistry, molecular biology and cell biology are applied, in conjunction with primary cell culture and engineered mice, to dissect the molecular basis of cellular machinery. In sum, I strongly believe elucidating the basis of molecular pathways will provide the most benefits in understanding human diseases.
Yao, J.-J., Gao, X.-F., Chow, C.W., Zhan, X.-Q., and Mei, Y.-A. (2012) Neuritin Activates Insulin Receptor Pathway to Upregulate Kv4.2-mediated IA in Rat Cerebellar Granule Neurons J Biol Chem. 287, 41534-45. PMID: 23066017 PMCID:PMC3510849.
Ding, B., Wang, W., Selvakumar, T., Xi, H.S., Zhu, H., Chow, C.W., Horton, J.D., Gronostajski, R., and Kilpatrick, D.L. (2013) Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons. J. Neurosci. 33, 2860-72. PMID: 23407945 PMCID:PMC3711774.
Suk, H.Y., Zhou, C., Yang, T.C., Zhu, H., Yu, R.Y.L., Olabisi, O A., Yang, X.Y., Brancho, D., Kim, J.Y., Scherer, P.E., Frank, P.G., Listani, M.P., Calvert, J.W., Lefer, D.J., Molkentin, J.D., Ghigo, A., Hirsch, E., Jin, J., Chow, C.W. (2013) Ablation of Calcineurin Ab Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases. J Biol Chem. 288, 3477-88. PMID: 23258544 PMCID:PMC3561567.
Zhu, H., Guariglia, S., Yu, R.Y.L., Li, W., Brancho, D., Peinado, H., Lyden, D., Salzer, J., Bennett, C., and Chow, C.W. (2013) Mutation of SIMPLE in Charcot-Marie-Tooth 1C Alters Production of Exosomes. Mol Biol Cell. 24, 1619-37. PMID: 23576546 PMCID:PMC3667717.
Nicholson, C.K., Lambert, J.P., Chow, C.W., Lefer, D.J. and Calvert, J.W. (2013) Chronic exercise downregulates myocardial myoglobin and attentuates nitrite reductase capacity during ischemia-reperfusion. J Mol Cell Card. 64, 1-10. PMID: 23962643 PMCID:PMC3800246.
Zhu, H., Li, W., Brancho, D., Wang, Z.V., Scherer, P.E., and Chow, C.W. (2014) Role of Extracellular Signal-Regulated Kinase 5 in Adipocyte Signaling. . J Biol Chem. 289, 6311-22.