Department of Microbiology & Immunology

Student Publications

 

Ariola Bardhi, Goldstein Lab

Chen, W., A. Bardhi, Y. Feng, Y. Wang, Q. Qi, W. Li, Z. Zhu, M. A. Dyba, T. Ying, S. Jiang, H. Goldstein, and D. S. Dimitrov. 2016. Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1. MAbs 8: 761-774

 

 

 

 

Cindy Buffone, Diaz-Griffero Lab

Fricke, T., C. Buffone, S. Opp, J. Valle-Casuso, and F. Diaz-Griffero. 2014. BI-2 destabilizes HIV-1 cores during infection and prevents binding of CPSF6 to the HIV-1 capsid. Retrovirology 11:120

Schulte, B., C. Buffone, S. Opp, F. Di Nunzio, D. A. De Souza Aranha Vieira, A. Brandariz-Nunez, and F. Diaz-Griffero. 2015. Restriction of HIV-1 requires the N-terminal region of MxB as a capsid-binding motif but not as a nuclear localization signal. J Virol 89:8599-8610

Buffone, C., B. Schulte, S. Opp, and F. Diaz-Griffero. 2015. Contribution of MxB oligomerization to HIV-1 capsid binding and restriction. J Virol 89:3285-3294

Thenin-Houssier, S., I. M. de Vera, L. Pedro-Rosa, A. Brady, A. Richard, B. Konnick, S. Opp, C. Buffone, J. Fuhrmann, S. Kota, B. Billack, M. Pietka-Ottlik, T. Tellinghuisen, H. Choe, T. Spicer, L. Scampavia, F. Diaz-Griffero, D. J. Kojetin, and S. T. Valente. 2016. Ebselen, a small-molecule capsid inhibitor of HIV-1 replication. Antimicrob Agents Chemother 60: 2195-2208

Chen, N. Y., L. Zhou, P. J. Gane, S. Opp, N. J. Ball, G. Nicastro, M. Zufferey, C. Buffone, J. Luban, D. Selwood, F. Diaz-Griffero, I. Taylor, and A. Fassati. 2016. HIV-1 capsid is involved in post-nuclear entry steps. Retrovirology 13: 28

Bhattacharya, A., Z. Wang, T. White, C. Buffone, L. A. Nguyen, C. N. Shepard, B. Kim, B. Demeler, F. Diaz-Griffero, and D. N. Ivanov. 2016. Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect. Sci Rep 6: 31353

 

 

 

 

Clare Burn, Herold Lab

Petro, C. D., B. Weinrick, N. Khajoueinejad, C. Burn, R. Sellers, W. R. Jacobs, Jr., and B. C. Herold. 2016. HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates. JCI Insight 1

 

 

 

Jordan Chinai, Zang Lab 

Zhao, R., J. M. Chinai, S. Buhl, L. Scandiuzzi, A. Ray, H. Jeon, K. C. Ohaegbulam, K. Ghosh, A. Zhao, M. D. Scharff, and X. Zang. 2013. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function. Proc Natl Acad Sci U S A 110:9879-9884

Jeon, H., V. Vigdorovich, S. C. Garrett-Thomson, M. Janakiram, U. A. Ramagopal, Y. M. Abadi, J. S. Lee, L. Scandiuzzi, K. C. Ohaegbulam, J. M. Chinai, R. Zhao, Y. Yao, Y. Mao, J. A. Sparano, S. C. Almo, and X. Zang. 2014. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep 9:1089-1098

Janakiram, M., J. M. Chinai, S. Fineberg, A. Fiser, C. Montagna, R. Medavarapu, E. Castano, H. Jeon, K. C. Ohaegbulam, R. Zhao, A. Zhao, S. C. Almo, J. A. Sparano, and X. Zang. 2015. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin Cancer Res 21:2359-2366

Chinai, J. M., M. Janakiram, F. Chen, W. Chen, M. Kaplan, and X. Zang. 2015. New immunotherapies targeting the PD-1 pathway. Trends Pharmacol Sci 36: 587-595

Janakiram, M., J. M. Chinai, A. Zhao, J. A. Sparano, and X. Zang. 2015. HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families. Oncoimmunology 4: e1026534

Koirala, P., M. E. Roth, J. Gill, J. M. Chinai, M. R. Ewart, S. Piperdi, D. S. Geller, B. H. Hoang, Y. V. Fatakhova, M. Ghorpade, X. Zang, and R. Gorlick. 2016. HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival. Sci Rep 6: 31154

Koirala, P., M. E. Roth, J. Gill, S. Piperdi, J. M. Chinai, D. S. Geller, B. H. Hoang, A. Park, M. A. Fremed, X. Zang, and R. Gorlick. 2016. Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma. Sci Rep 6: 30093

Cheng, H., M. Janakiram, A. Borczuk, J. Lin, W. Qiu, H. Liu, J. M. Chinai, B. Halmos, R. Perez-Soler, and X. Zang. 2017. HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with EGFR mutational status. Clin Cancer Res 23: 825-832

 

 

 

Evan Der, Putterman Lab 

Xia, Y., E. Eryilmaz, E. Der, R. D. Pawar, X. Guo, D. Cowburn, and C. Putterman. 2016. A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens. Clin Exp Immunol 183: 369-379

Chalmers, S. A., J. Doerner, T. Bosanac, S. Khalil, D. Smith, C. Harcken, J. Dimock, E. Der, L. Herlitz, D. Webb, E. Seccareccia, D. Feng, J. S. Fine, M. Ramanujam, E. Klein, and C. Putterman. 2016. Therapeutic blockade of immune complex-mediated glomerulonephritis by highly selective inhibition of Bruton's tyrosine kinase. Sci Rep 6: 26164

Der, E., S. Ranabothu, H. Suryawanshi, K. M. Akat, R. Clancy, P. Morozov, M. Kustagi, M. Czuppa, P. Izmirly, H. M. Belmont, T. Wang, N. Jordan, N. Bornkamp, J. Nwaukoni, J. Martinez, B. Goilav, J. P. Buyon, T. Tuschl, and C. Putterman. 2017. Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis. JCI Insight 2

 

 

 

Max Fels, Chandran Lab 

Wec, A. Z., A. S. Herbert, C. D. Murin, E. K. Nyakatura, D. M. Abelson, J. M. Fels, S. He, R. M. James, M. A. de La Vega, W. Zhu, R. R. Bakken, E. Goodwin, H. L. Turner, R. K. Jangra, L. Zeitlin, X. Qiu, J. R. Lai, L. M. Walker, A. B. Ward, J. M. Dye, K. Chandran, and Z. A. Bornholdt. 2017. Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses. Cell 169: 878-890

Zhao, X., K. A. Howell, S. He, J. M. Brannan, A. Z. Wec, E. Davidson, H. L. Turner, C. I. Chiang, L. Lei, J. M. Fels, H. Vu, S. Shulenin, A. N. Turonis, A. I. Kuehne, G. Liu, M. Ta, Y. Wang, C. Sundling, Y. Xiao, J. S. Spence, B. J. Doranz, F. W. Holtsberg, A. B. Ward, K. Chandran, J. M. Dye, X. Qiu, Y. Li, and M. J. Aman. 2017. Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability. Cell 169: 891-904

 

 

 

Nina Flerin, Goldstein Lab

Flerin, N. C., H. Chen, T. D. Glover, P. A. Lamothe, J. H. Zheng, J. W. Fang, Z. M. Ndhlovu, E. W. Newell, M. M. Davis, B. D. Walker, and H. Goldstein. 2017. T-cell receptor (TCR) clonotype-specific differences in inhibitory activity of HIV-1 cytotoxic T-cell clones is not mediated by TCR alone. J Virol 91

 

 

 

Erik Hasenoehrl, Berney Lab

Kalia, N. P., E. J. Hasenoehrl, N. B. Ab Rahman, V. H. Koh, M. L. T. Ang, D. R. Sajorda, K. Hards, G. Gruber, S. Alonso, G. M. Cook, M. Berney, and K. Pethe. 2017. Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. Proc Natl Acad Sci USA 114: 7426-7431

Cook, G. M., K. Hards, E. Dunn, A. Heikal, Y. Nakatani, C. Greening, D. C. Crick, F. L. Fontes, K. Pethe, E. Hasenoehrl, and M. Berney. 2017. Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions. Microbiol Spectr 5

 

 

 

Peter John, Zang Lab 

Sankin, A., D. Narasimhulu, P. John, B. Gartrell, M. Schoenberg, and X. Zang. 2017. The expanding repertoire of targets for immune checkpoint inhibition in bladder cancer: What lies beneath the tip of the iceberg, PD-L1. Urol Oncol

 

 

 

Christopher Johndrow, Porcelli Lab 

Arora, P., S. S. Kharkwal, T. W. Ng, S. Kunnath-Velayudhan, N. K. Saini, C. T. Johndrow, Y. T. Chang, G. S. Besra, and S. A. Porcelli. 2015. Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes. Chem Phys Lipids 191: 75-83

 

 

 

Steven Kennedy, Porcelli Lab 

Ng, T. W., N. A. Saavedra-Avila, S. C. Kennedy, L. J. Carreno, and S. A. Porcelli. 2015. Current efforts and future prospects in the development of live mycobacteria as vaccines. Expert Rev Vaccines 14: 1493-1507

Saini, N. K., A. Baena, T. W. Ng, M. M. Venkataswamy, S. C. Kennedy, S. Kunnath-Velayudhan, L. J. Carreno, J. Xu, J. Chan, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2016. Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47. Nat Microbiol 1: 16133

Johnson, A. J., S. C. Kennedy, C. S. Lindestam Arlehamn, M. F. Goldberg, N. K. Saini, J. Xu, S. Paul, S. S. Hegde, J. S. Blanchard, J. Chan, W. R. Jacobs, Jr., A. Sette, and S. A. Porcelli. 2017. Identification of mycobacterial RplJ/L10 and RpsA/S1 proteins as novel targets for CD4+ T cells. Infect Immun 85

 

 

 

Lara Kleinfelter, Chandran Lab 

Kleinfelter, L. M., R. K. Jangra, L. T. Jae, A. S. Herbert, E. Mittler, K. M. Stiles, A. S. Wirchnianski, M. Kielian, T. R. Brummelkamp, J. M. Dye, and K. Chandran. 2015. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6

Hastie, K. M., M. A. Zandonatti, L. M. Kleinfelter, M. L. Heinrich, M. M. Rowland, K. Chandran, L. M. Branco, J. E. Robinson, R. F. Garry, and E. O. Saphire. 2017. Structural basis for antibody-mediated neutralization of Lassa virus. Science 356: 923-928

 

 

 

Jamie Moore, Chandran Lab 

Spaulding, E., D. Fooksman, J. M. Moore, A. Saidi, C. M. Feintuch, B. Reizis, L. Chorro, J. Daily, and G. Lauvau. 2016. STING-licensed macrophages prime type I IFN production by plasmacytoid dendritic cells in the bone marrow during severe Plasmodium yoelii malaria. PLoS Pathog 12: e1005975

 

 

 

Kim Ohaegbulam, Zang Lab 

Zhao, R., J. M. Chinai, S. Buhl, L. Scandiuzzi, A. Ray, H. Jeon, K. C. Ohaegbulam, K. Ghosh, A. Zhao, M. D. Scharff, and X. Zang. 2013. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function. Proc Natl Acad Sci U S A 110:9879-9884

Abadi, Y. M., H. Jeon, K. C. Ohaegbulam, L. Scandiuzzi, K. Ghosh, K. A. Hofmeyer, J. S. Lee, A. Ray, C. Gravekamp, and X. Zang. 2013. Host B7x promotes pulmonary metastasis of breast cancer. J Immunol 190:3806-3814

Jeon, H., K. C. Ohaegbulam, Y. M. Abadi, and X. Zang. 2013. B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities. Oncoimmunology 2:e24744

Jeon, H., V. Vigdorovich, S. C. Garrett-Thomson, M. Janakiram, U. A. Ramagopal, Y. M. Abadi, J. S. Lee, L. Scandiuzzi, K. C. Ohaegbulam, J. M. Chinai, R. Zhao, Y. Yao, Y. Mao, J. A. Sparano, S. C. Almo, and X. Zang. 2014. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep 9:1089-1098

Janakiram, M., J. M. Chinai, S. Fineberg, A. Fiser, C. Montagna, R. Medavarapu, E. Castano, H. Jeon, K. C. Ohaegbulam, R. Zhao, A. Zhao, S. C. Almo, J. A. Sparano, and X. Zang. 2015. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin Cancer Res 21:2359-2366

Ohaegbulam, K. C., A. Assal, E. Lazar-Molnar, Y. Yao, and X. Zang. 2015. Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway. Trends Mol Med 21:24-33

Picarda, E., K. C. Ohaegbulam, and X. Zang. 2016. Molecular pathways: Targeting B7-H3 (CD276) for human cancer immunotherapy. Clin Cancer Res 22: 3425-3431

 

 

 

Jennifer Schloss, DiLorenzo Lab 

Babad, J., R. Ali, J. Schloss, and T. P. DiLorenzo. 2016. An HLA-transgenic mouse model of type 1 diabetes that incorporates the reduced, but not abolished, thymic insulin expression seen in patients. J. Diabetes Res 2016:7959060

Sidney, J., J. Schloss, C. Moore, M. Lindvall, A. Wriston, D. F. Hunt, J. Shabanowitz, T. P. DiLorenzo, and A. Sette. 2016. Characterization of the peptide binding specificity of the HLA class I alleles B*38:01 and B*39:06. Immunogenetics 68:231-236

Mukherjee, G., R. J. Chaparro, J. Schloss, C. Smith, C. D. Bando, and T. P. DiLorenzo. 2015. Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice. Immunology 144:631-640

 

 

 

Ariel Dov Stock, Putterman Lab 

Wen, J., Y. Xia, A. Stock, J. S. Michaelson, L. C. Burkly, M. Gulinello, and C. Putterman. 2013. Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway. J Autoimmun 43:44-54

Stock, A. D., J. Wen, and C. Putterman. 2013. Neuropsychiatric lupus, the blood brain barrier, and the TWEAK/Fn14 pathway. Front Immunol 4:484

Wen, J., J. Doerner, K. Weidenheim, Y. Xia, A. Stock, J. S. Michaelson, K. Baruch, A. Deczkowska, M. Gulinello, M. Schwartz, L. C. Burkly, and C. Putterman. 2015. TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice. J Autoimmun 60:40-50

Stock, A. D., J. Wen, J. Doerner, L. C. Herlitz, M. Gulinello, and C. Putterman. 2015. Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice. J Neuroinflammation 12: 205

Wen, J., C. H. Chen, A. Stock, J. Doerner, M. Gulinello, and C. Putterman. 2016. Intracerebroventricular administration of TNF-like weak inducer of apoptosis induces depression-like behavior and cognitive dysfunction in non-autoimmune mice. Brain Behav Immun 54: 27-37

Wen, J., J. Doerner, S. Chalmers, A. Stock, H. Wang, M. Gullinello, M. J. Shlomchik, and C. Putterman. 2016. B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus. J Neuroinflammation 13: 73

Wen, J., A. D. Stock, S. A. Chalmers, and C. Putterman. 2016. The role of B cells and autoantibodies in neuropsychiatric lupus. Autoimmun Rev 15: 890-895

Stock, A. D., S. Gelb, O. Pasternak, A. Ben-Zvi, and C. Putterman. 2017. The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface. Autoimmun Rev 16: 612-619

 

 

 

Anna Wec, Chandran Lab 

Howell, K. A., X. Qiu, J. M. Brannan, C. Bryan, E. Davidson, F. W. Holtsberg, A. Z. Wec, S. Shulenin, J. E. Biggins, R. Douglas, S. G. Enterlein, H. L. Turner, J. Pallesen, C. D. Murin, S. He, A. Kroeker, H. Vu, A. S. Herbert, M. L. Fusco, E. K. Nyakatura, J. R. Lai, Z. Y. Keck, S. K. Foung, E. O. Saphire, L. Zeitlin, A. B. Ward, K. Chandran, B. J. Doranz, G. P. Kobinger, J. M. Dye, and M. J. Aman. 2016. Antibody treatment of Ebola and Sudan virus infection via a uniquely exposed epitope within the glycoprotein receptor-binding site. Cell Rep 15: 1514-1526

Wec, A. Z., E. K. Nyakatura, A. S. Herbert, K. A. Howell, F. W. Holtsberg, R. R. Bakken, E. Mittler, J. R. Christin, S. Shulenin, R. K. Jangra, S. Bharrhan, A. I. Kuehne, Z. A. Bornholdt, A. I. Flyak, E. O. Saphire, J. E. Crowe, Jr., M. J. Aman, J. M. Dye, J. R. Lai, and K. Chandran. 2016. A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses. Science 354: 350-354

Froude, J. W., T. Pelat, S. Miethe, S. E. Zak, A. Z. Wec, K. Chandran, J. M. Brannan, R. R. Bakken, M. Hust, P. Thullier, and J. M. Dye. 2017. Generation and characterization of protective antibodies to Marburg virus. MAbs 9: 696-703

Wec, A. Z., A. S. Herbert, C. D. Murin, E. K. Nyakatura, D. M. Abelson, J. M. Fels, S. He, R. M. James, M. A. de La Vega, W. Zhu, R. R. Bakken, E. Goodwin, H. L. Turner, R. K. Jangra, L. Zeitlin, X. Qiu, J. R. Lai, L. M. Walker, A. B. Ward, J. M. Dye, K. Chandran, and Z. A. Bornholdt. 2017. Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses. Cell 169: 878-890

Zhao, X., K. A. Howell, S. He, J. M. Brannan, A. Z. Wec, E. Davidson, H. L. Turner, C. I. Chiang, L. Lei, J. M. Fels, H. Vu, S. Shulenin, A. N. Turonis, A. I. Kuehne, G. Liu, M. Ta, Y. Wang, C. Sundling, Y. Xiao, J. S. Spence, B. J. Doranz, F. W. Holtsberg, A. B. Ward, K. Chandran, J. M. Dye, X. Qiu, Y. Li, and M. J. Aman. 2017. Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability. Cell 169: 891-904

 

 

 

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