Selected recent publications:
M Bujak, G Ren, HJ Kweon, M Dobaczewski, A Reddy, G Taffet, XF Wang, and NG Frangogiannis. Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling. Circulation 2007; 116:2127-38.
P Huebener, T Abou-Khamis, P Zymek, M Bujak, Ying X, K Chatila, S Haudek, G Thakker, and NG Frangogiannis, CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol 2008; 180:2625-33.
M Bujak, HJ Kweon, K Chatila, N Li, G Taffet, and NG Frangogiannis. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol 2008; 51:1384-92.
M Bujak, M Dobaczewski, K Chatila, L Mendoza, N Li, A Reddy, and NG Frangogiannis. Interleukin-1 type (IL-1RI) signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 2008; 173:57-67.
M Bujak, M Dobaczewski, C Gonzalez-Quesada, Y Xia, T Leucker, P Zymek, V Veeranna, A Tager, A Luster, and NG Frangogiannis. Induction of the CXC Chemokine Interferon-g-Inducible Protein (IP)-10 Regulates the Reparative Response Following Myocardial Infarction. Circ Res 2009; 105:973-83.
M Dobaczewski, Y Xia, M Bujak, C Gonzalez-Quesada, and NG Frangogiannis. CCR5 signaling suppresses inflammation and reduces adverse remodeling following myocardial infarction mediating recruitment of regulatory T cells. Am J Pathol 2010; 176: 2177-87.
M Dobaczewski, M Bujak, N Li, C Gonzalez-Quesada; LH Mendoza, XF Wang, and NG Frangogiannis. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res 2010; 107 (3): 418-28.
M Dobaczewski, W Chen and NG Frangogiannis. Transforming Growth Factor (TGF)-beta signaling in cardiac remodeling. J Mol Cell Cardiol 2011; 51:600-606.
NG Frangogiannis. The SDF-1/CXCR4 axis in cardiac injury and repair. J Am Coll Cardiol 2011; 58: 2424-2426.
Y Xia, M Dobaczewski, C Gonzalez-Quesada, W Chen, A Biernacka, N Li, D Lee, and NG Frangogiannis. Endogenous Thrombospondin-1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension 2011; 58: 902-911.
NG Frangogiannis. Regulation of the inflammatory response in cardiac repair. Circ Res 2012: 110: 159-173.
NG Frangogiannis. Matricellular proteins in cardiac adaptation and disease. Physiol Rev 2012; 92:635-688.
W Chen, A Saxena, N Li, J Sun, DW Lee, Q Tian, M Dobaczewski, and NG Frangogiannis. Endogenous IRAK-M attenuates post-infarction remodeling through effects on macrophages and fibroblasts. Arterioscl Thromb Vasc Biol 2012; 32:2598-608.
W Chen and NG Frangogiannis. Fibroblasts in post-infarction inflammation and cardiac repair. BBA Mol Basis Dis. 2013; 1833:945-53
P Christia, M Bujak, C Gonzalez-Quesada, W Chen, M Dobaczewski, A Reddy, and NG Frangogiannis. Systematic characterization of myocardial inflammation, repair and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem 2013; 61:555-570.
P Christia, and NG Frangogiannis. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest 2013; 43: 986-95.
P Kong, C Gonzalez-Quesada, N Li, M Cavalera, D-W Lee, and NG Frangogiannis. Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab 2013; 305:E439-450.
P Kong, P Christia, A Saxena, Y Su, and NG Frangogiannis. Lack of specificity of Fibroblast Specific Protein (FSP)1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol 2013;305(9):H1363-72.
A Saxena, W Chen, Y Su, V Rai, OU Uche, N Li, and NG Frangogiannis. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol 2013; 191(9):4838-48.
C Gonzalez-Quesada, M Cavalera, A Biernacka, P Kong, DW Lee, A Saxena, O Frunza, M Dobaczewski, AV Shinde, and NG Frangogiannis. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix while promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res 2013; 113(12):1331-44.
P Kong, P Christia, and NG Frangogiannis. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci 2014 ; 71: 549-574.
AV Shinde and NG Frangogiannis. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 2014; 70:74-82.
NG Frangogiannis. The inflammatory response in myocardial injury, repair and remodeling. Nat Rev Cardiol 2014; 11:255-265.
A Saxena, M Bujak, O Frunza, M Dobaczewski, C Gonzalez-Quesada, B Lu, C Gerard, and NG Frangogiannis. CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans. Cardiovasc Res 2014; 103:217-227.
M Cavalera, J Wang, and NG Frangogiannis. Obesity, metabolic dysfunction and cardiac fibrosis: pathophysiologic pathways, molecular mechanisms and therapeutic opportunities. Transl Res 2014; 164:323-335.
A Saxena, M Dobaczewski, V Rai, Z Haque, W Chen, N Li, and NG Frangogiannis. Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function. Am J Physiol Heart Circ Physiol 2014; 307(8):H1233-42.
NG Frangogiannis. The pathophysiology of myocardial infarction. Compr Physiol 2015; 5:1841-75.
AV Shinde and NG Frangogiannis. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium Circ Res 2015; 117:10-12.
A Biernacka, M Cavalera, J Wang, I Russo, A Shinde, P Kong, C Gonzalez-Quesada, V Rai, M Dobaczewski, DW Lee, XF Wang, and NG Frangogiannis. Smad3 signaling promotes fibrosis, while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail 2015; 8: 788-798.
A Saxena, AV Shinde, Z Haque, YJ Wu, W Chen, Y Su, and NG Frangogiannis. The role of Interleukin receptor associated kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction. J Mol Cell Cardiol 2015; 89: 223-31.
NG Frangogiannis. The reparative function of cardiomyocytes in the infarcted myocardium Cell Metab 2015; 21: 797-798.
NG Frangogiannis. Emerging roles for macrophages in cardiac injury: cytoprotection, repair and regeneration J Clin Invest 2015; 125: 2927-30.
I Russo, and NG Frangogiannis. Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol 2015; 90:84-93.
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.