Research Development Core

The mission of the Research Development Core is to ensure the future of Biology of Aging research through mentoring, pilot & feasibility funding, and education.

Personnel

Directors: Rajat Singh, MBBS and Sofiya Milman, MD

Mentoring

Mentors include Einstein faculty who are members of the Einstein Nathan Shock center.

Pilot & Feasibility Awards

All members of the Einstein NSC, external members, and all other NSCs are eligible for P&F awards. The awards go toward the use of unique Einstein-NSC Core services.

P&F Applications

The submission deadline for 2019 P&F applications has passed and the funds have been awarded. Please check back soon for the next P&F call for applications.

P&F Awardees

Funded 2015
Name Short Title
Arias-Perez, E Crosstalk between autophagic pathways with age
Delahaye, F Methylation signature of an advanced aging phenotype
Frenette, P Impact of aging on the bone marrow stem cells microenvironment
Funded 2016
Name Short Title
Buelow, H Comprehensive Approach Towards Understanding Neuronal Aging
Huffman, D Shlp2 in prevention of age-related functional and cognitive decline
Funded 2017
Name Short Title
Lee, D Central action of mitochondrial-derived peptides
Lamming, D Youthful circulating factors and cardiovascular disease
Promislow, D Epigenetics and epigenetic memory in aging fruit fly
Sell, C Longevity and Histone modifications
Shen, Y Defining regulators of aging in epithelial stem cells
Stout, M Age/sex specific metabolic responses to 17 a-estradiol
Funded 2018
Name Short Title
Radhakrishnan, S Nrf1 in the autophagy pathways
Zhu, Q C9ORF72 and autophagy in neurons
Stout, M Hypothalamic ERα in age-related hepatic gluconeogenesis
Cohen, P MOTS-C can act centrally to regulate insulin sensitivity
Mar, J Metformin action with age in single cells using sc-RNA-SEQ
Mason, J Ovarian transplantation and DNA methylation fingerprints
Murach, K Skeletal muscle epigenetics with aging
Perls, T Somatic mutations in the blood of centenarians
Delahaye, F Single cell on microglia
Funded 2019
Name Short Title
Niedernhofer, L Autophagy profiling in cells from progeroid, DNA repair-deficient mice
Sutphin, G Evaluating mechanisms of improved proteostasis following interventions in kynurenine metabolism
Cortes, C Enhanced skeletal muscle proteostasis as a determinant of CNS aging
Skowronska-Krawczyk, D Role of ELOVL2 in aging
Allani, S Role of Methionine sulfoxide reductase (MSR) system in aging
Wang, G/Driscoll M The transcriptomic response to cytoplasmic or mitochondrial superoxide dysregulation

Table 1. P&F applications from prior funding cycle (2015-2018) and those selected for funding in 2019.

Education

Graduate Course in the Biology of Aging

Course Leaders: Ana Maria Cuervo, Md, PhD and Nir Barzilai, MD

The course presents an in-depth analysis of the biology of aging, building up from changes occurring at the molecular and cellular level and analyzing the consequences at the organism level. In addition, the influence of these age-related changes in what are commonly considered a disease of aging, such as neurodegeneration, diabetes, etc, will also be discussed. Topics will include: theories of aging, experimental models used to study of aging and longevity, impact of oxidative stress in cell and organ function, the metabolic syndrome of aging, functional changes in the immune, musculoskeletal and central nervous systems, genetic instability and genetics of aging and longevity. The goal of this course is to motivate an interest among our graduates for problems in biology of aging and to prepare them for the growing demand for future generations of aging researchers.

Hackathon: "Can we hack the Fountain of Youth?"

Hackathon leader: Jessica Mar, PhD

A friendly 2-day completion among Einstein graduate students, postdoctoral fellows, and faculty that aims to improve the science of aging via innovative investigations of existing aging-related datasets.

Links to the Einstein Hackathon 2017