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Lisa Scandiuzzi

   Lisa Scandiuzzi, Ph.D.

Research Fellow
Department of Microbiology & Immunology
Albert Einstein College of Medicine
Forchheimer Building, Room 405
Bronx, NY 10461
Tel: 718-430-4154
Fax: 718-430-8711
Email: lisa.scandiuzzi@einstein.yu.edu


Dr. Lisa Scandiuzzi graduated in Biotechnology from the Verona University in Italy, where she started her research experience on the signaling pathway in the macrophage movement in the Department of Pathology with Pr. Giorgio Berton. She then moved to Paris where she obtained a Ph.D in Immunology at the Bichat Medical School of University of Medicine Paris VII under the supervision of Dr. Ulrich Blank. During her Ph.D studies she demonstrated, in an experimental model of glomerulonephritis, that mast cell can exert either a protective role through fibrinolytic-remodeling processes or a deleterious role by activation of mast cell mediators such as the protease mMCP-4. In February 2009 she started her post-doc at the Albert Einstein College of Medicine with Dr. Xingxing Zang studying new pathways for T cell costimulation and coinhibition and related diseases.

Publications:

Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function. Proceedings of the National Academy of Sciences USA, 110:9879-9884, 2013.

Abadi YM, Jeon H, Ohaegbulam KC, Scandiuzzi L, Ghosh K, Hofmeyer KA, Lee JS, Ray A, Gravekamp C, Zang X. Host B7x promotes pulmonary metastasis of breast cancer. The Journal of Immunology, 190:3806-3814, 2013.

Lee JS*, Scandiuzzi L*, Ray A, Wei J, Hofmeyer KA, Abadi MY, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X. B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells. The Journal of Immunology, 189:4165-4174, 2012.
(*co-first authors)

Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X. Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection. The Journal of Immunology, 189:3054-3063, 2012.

Scandiuzzi L, Ghosh K, Zang X. T cell costimulation and coinhibition: Genetics and disease (Review). Discovery Medicine, 12:119-128, 2011.

Scandiuzzi L, Beghdadi W, Daugas E, Åbrink M, Tiwari N, Brochetta C, Claver J, Arouche N, Zang X, Pretolani M, Monteiro RC, Pejler G, Blank U. Mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. The Journal of Immunology, 185:624-633, 2010.

Tiwari N, Wang CC, Brochetta C, Scandiuzzi L, Hong W, Blank U. Increased formation of VAMP-3-containig SNARE complexes in mast cells from VAMP-8 deficient cells. Inflammation Research, 2009 January 1-2

Brochetta C, Vita F, Tiwari N, Scandiuzzi L, Soranzo MR, Guérin-Marchand C, Zabucchi G, Blank U. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. BBA Molecular Cell Research, 1783:1781-91, 2008.

Blank U, Essig M, Scandiuzzi L, Benhamou M, Kanamaru Y. Mast cells and inflammatory kidney disease. Immunological Review, 217:79-95, 2007.

Scandiuzzi L*, Kanamaru Y*, Essig M, Brochetta C, Guérin-Marchand C, Tomino Y, Monteiro RC, Peuchmaur M, Blank U. Mast cell mediated remodelling and fibrinolytic activity protects against fatal glomerulonephritis. The Journal of Immunology, 176:5607-15, 2006.
(*co-first authors)


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