Xingxing Zang Laboratory


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   Selected Publications

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x and B7-H3    PDF
Janakiram M, Shah UA, Liu W, Zhao A, Schoenberg MP, Zang X.
Immunological Reviews, 276:26-39, 2017
A review of the PD-1/PD-L1 checkpoint in bladder cancer: from mediator of immune escape to target for treatment    PDF
Zhou TC, Sankin AI, Porcelli SA, Perlin DS, Schoenberg MP, Zang X.
Urologic Oncology: Seminars and Original Investigations, 35:14-20, 2017
HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with EGFR mutational status    PDF
Cheng H, Janakiram M, Borczuk A, Lin J, Qiu W, Liu H, Chinai JM, Halmos B, Perez-Soler R, Zang X.
Clinical Cancer Research, 23:825-832, 2017
HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival    PDF
Koirala P, Roth M, Gill J, Chinai J, Ewart M, Piperdi S, Geller D, Hoang B, Fatakhova K, Ghorpade M, Zang X*, Gorlick R*.
Scientific Reports, 6:31154. doi: 10.1038/srep31154, 2016
Molecular pathways: Targeting B7-H3 (CD276) for human cancer immunotherapy    PDF
Picarda E, Ohaegbulam KC, Zang X.
Clinical Cancer Research, 22:3425-3431, 2016
Tumor infiltrating lymphocytes as a prognostic and predictive biomarker in breast cancer (book chapter)    PDF
Janakiram M, Khan H, Fineberg S, Zang X, Sparano JA.
Molecular Pathology of Breast Cancer, Springer, 167-186, 2016
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma    PDF
Koirala P, Roth M, Gill J, Piperdi S, Chinai J, Geller D, Hoang B, Park A, Fremed M, Zang X, Gorlick R.
Scientific Reports, 6:30093. doi: 10.1038/srep30093, 2016
Immune checkpoint blockade in human cancer therapy: Lung cancer and hematopoietic malignancy    PDF
Janakiram M, Pareek V, Cheng H, Narasimhulu D, Zang X.
Immunotherapy, 8:809-819, 2016
Co-stimulate or co-inhibit regulatory T cells, which side to go?    PDF
Liu W, Almo SC, Zang X.
Immunological Investigations, 45:813-831, 2016
B7-H4(B7x)-mediated cross-talk between glioma-initiating cells and macrophages via the IL-6/JAK/STAT3 pathway lead to poor prognosis in glioma patients    PDF
Yao Y, Ye H, Qi Z, Mo L, Yue Q, Baral A, Hoon DSB, Vera JC, Heiss JD, Chen CC, Hua W, Zhang J, Jin K, Wang Y, Zang X*, Mao Y*, Zhou L*
Clinical Cancer Research, 22:2778-2790, 2016
Emerging targets in cancer immunotherapy: beyond CTLA-4 and PD-1    PDF
Assal A, Kaner J, Pendurti G, Zang X.
Immunotherapy, 7:1169-1186, 2015
New immunotherapies targeting the PD-1 pathway    PDF
Chinai JM, Janakiram M, Chen F, Chen W, Kaplan M, Zang X.
Trends in Pharmacological Sciences, 36:587-595, 2015
The T-cell inhibitory molecule Butyrophilin-like 2 is up-regulated in mild Plasmodium falciparum infection and is protective during experimental cerebral malaria    PDF
Subramaniam KS, Spaulding E, Ivan E, Mutimura E, Kim R, Liu X, Dong C, Feintuch CM, Zang X, Anastos K, Lauvau G, Daily JP.
The Journal of Infectious Diseases, 212:1322–31, 2015
HHLA2 and TMIGD2: New immunotherapeutic targets of the B7 and CD28 families    PDF
Janakiram M, Chinai JM, Zhao A, Sparano JA, Zang X.
OncoImmunology, 4: e1026534-1 - e1026534-3, 2015
Substituting threonine187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age    PDF
Zhao H, Bauzon F, Bi E, Yu JJ, Fu H, Lu Z, Cui J, Jeon H, Zang X, Ye BH, Zhu L.
Journal of Biological Chemistry, 290:5797-5809, 2015
Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway    PDF
Ohaegbulam KC, Assal A, Lazar-Molnar E, Yao Y, Zang X.
Trends in Molecular Medicine, 21:24-33, 2015
B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody mediated nephritis    PDF
Pawar RD, Goilav B, Xia Y, Herlitz L, Doerner J, Chalmers S, Ghosh K, Zang X, Putterman C.
Clinical & Experimental Immunology, 179:329-343, 2014
Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein    PDF
Janakiram M, Chinai JM, Fineberg S, Fiser A, Montagna C, Medaverepu R, Castano E, Jeon H, Ohaegbulam KC, Zhao R, Zhao A, Almo SC, Sparano JA, Zang X.
Clinical Cancer Research, 21:2359-2366, 2015
Structure and cancer immunotherapy of the B7 family member B7x (B7-H4/B7S1)    PDF
Jeon H, Vigdorovich V, Garrett-Thomson SC, Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L, Ohaegbulam KC, Chinai JM, Zhao R, Yao Y, Mao Y, Sparano JA, Almo SC, Zang X.
Cell Reports, 9:1089-1098, 2014
* Science-Business eXchange   PDF
Tissue-expressed B7-H1 (PD-L1) critically controls intestinal inflammation    PDF
Scandiuzzi L, Ghosh K, Hofmeyer KA, Abadi YM, Lázár-Molnár E, Lin EY, Liu Q, Jeon H, Almo SC, Chen L, Nathenson SG, Zang X.
Cell Reports, 6:625-632, 2014
          Featured in PSI-SBKB Gateway   PDF
The B7 and CD28 families (Book chapter) PDF
Zang X.
Encyclopedia of Medical Immunology, I.R.Mackay and N.R. Rose, ed. Springer, 174-181, 2014
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function    PDF
Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X.
Proceedings of the National Academy of Sciences USA, 110:9879-9884, 2013
Curcumin improves the therapeutic efficacy of Listeria-Mage-b vaccine in correlation with improved T cell responses in blood of a triple negative breast cancer model 4T1    PDF
Singh M, Ramos L, Asafu-Adjei D, Quispe-Tintaya W, Chandra D, Jahangir A, Zang X, Aggarwal BB, Gravekamp C
Cancer Medicine, 2:571-582, 2013
B7x(B7-H4/B7S1) and myeloid derived suppressor cells in the tumor microenvironment: A tale of two cities    PDF
Jeon H, Ohaegbulam KC, Abadi YM, Zang X.
OncoImmunology, e24744-1-e24744-3, 2013
Structure and T cell coinhibition properties of B7 family member B7-H3    PDF
Vigdorovich V, Ramagopal U, Lazar-Molnar E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC.
Structure, 21:707-717, 2013
Host B7x promotes pulmonary metastasis of breast cancer    PDF
Abadi YM, Jeon H, Ohaegbulam KC, Scandiuzzi L, Ghosh K, Hofmeyer KA, Lee JS, Ray A, Gravekamp C, Zang X.
The Journal of Immunology, 190:3806-3814, 2013
T cell coinhibition and immunotherapy in human breast cancer    PDF
Janakiram M, Abadi YM, Sparano JA, Zang X.
Discovery Medicine, 14:229-236, 2012
B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells    PDF
Lee JS, Scandiuzzi L, Ray A, Wei J, Hofmeyer KA, Abadi MY, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X.
The Journal of Immunology, 189:4165-4174, 2012
Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection    PDF
Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X.
The Journal of Immunology, 189:3054-3063, 2012
T cell costimulation and coinhibition: Genetics and disease (Review)   PDF
Scandiuzzi L, Ghosh K, Zang X.
Discovery Medicine, 12:119-128, 2011
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion (Review)   PDF
Hofmeyer KA, Jeon H, Zang X.
Journal of Biomedicine and Biotechnology, 2011:451694, 2011
Tissue specific expression of B7x protects from CD4 T cell mediated autoimmunity   PDF
Wei J, Loke P, Zang X*, Allison JP*.
(* Co-corresponding authors)
Journal of Experimental Medicine, 208:1683-1694, 2011
T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics (Review)   PDF
Barach YS, Lee JS, Zang X.
Trends in Molecular Medicine, 17:47-55, 2011
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas   PDF
Zang X, Sullivan PS, Soslow RA, Waitz R, Reuter VE, Wilton A, Thaler HT, Arul M, Slovin SF, Wei J, Spriggs DR, Dupont J, Allison JP.
Modern Pathology, 23:1104-1112, 2010
Mouse Mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.   PDF
Scandiuzzi L, Beghdadi W, Daugas E, Abrink M, Tiwari N, Brochetta C, Claver J, Arouche N, Zang X, Pretolani M, Monteiro RC, Pejler G, Blank U.
The Journal of Immunology, 185:624-633, 2010
The contrasting role of B7-H3 (Commentary)   PDF
Hofmeyer KA, Ray A, Zang X.
Proceedings of the National Academy of Sciences USA, 105: 10277-10278, 2008
Serum soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage   PDF
Thompson RH*, Zang X*, Lohse CM, Leibovich BC, Slovin S, Reuter VE, Blute ML, Russo P, Kwon ED*, Allison JP*.
(*Contributed equally)
Cancer Research, 68: 6054-6058, 2008
The B7 family and cancer therapy: Costimulation and coinhibition (Review)   PDF
Zang X, Allison JP.
Clinical Cancer Research, 13: 5271-5279, 2007
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome   PDF
Zang X*, Thompson RH*, Al-Ahamadie A, Serio AM, Reuter VE, Eastham JA, Scardino PT, Sharma P, Allison JP.
(*Contributed equally)
Proceedings of the National Academy of Sciences USA, 104: 19458-19463, 2007
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface   PDF
Cao E*, Zang X*, Ramagopal UA*, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, DiLorenzo TP, Allison JP, Nathenson SG, Almo SC.
(*Contributed equally)
Immunity, 26: 311-321, 2007
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic Infection    PDF
Loke P, Gallagher I, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP, Allen JE.
Journal of Immunology, 179: 3926-3936, 2007
To be or not to be B7 (Commentary)   PDF
Zang X, Allison JP.
Journal of Clinical Investigation, 116: 2590-2593, 2006
A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors   PDF
Zang X, Loke P, Kim J, Wojnoonski K, Kusdra L, Allison JP.
Genomics, 88: 841-845, 2006
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection    PDF
Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen IE, Allison JP.
Proceedings of the National Academy of Sciences USA, 102: 9872-9877, 2005
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1   PDF
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM.
Nature Immunology, 4:670-679, 2003
B7x: A widely expressed B7 family member that inhibits T cell activation   PDF
Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP.
Proceedings of the National Academy of Sciences USA, 100: 10388-10392, 2003
Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi   
Emes R, Thompson F, Moore J, Zang X, Devaney E.
International Journal for Parasitology, 32:415-424, 2002
Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure   PDF
Zang X, Taylor P, Wang JM, Meyer DJ, Scott AL, Walkinshaw MD, Maizels RM.
Journal of Biological Chemistry, 277:44261-44267, 2002
A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection   PDF
Falcone FH, Loke P, Zang X, MacDonald AS, Maizels RM, Allen JE.
Journal of Immunology, 167: 5348-5354, 2001
Immune evasion genes from filarial nematodes (Review)    PDF
Maizels RM, Gomez-Escobar N, Gregory WF, Murray J, Zang X.
International Journal for Parasitology, 31:889-898, 2001
Serine proteinase inhibitors from nematodes and the arms race between host and pathogen (Review)   PDF
Zang X, Maizels RM.
Trends in Biochemical Sciences, 26:191-197, 2001
The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans    PDF
Zang X, Atmadia KA, Gray P, Allen JE, Gray CA, Lawrence RA, Yazdanbakhsh M, Maizels RM.
Journal of Immunology, 165:5161-5169, 2000
Vaccination against helminth parasites: the ultimate challenge for vaccinologists? (Review)   
Maizels RM, Holland M, Falcone F, Zang X, Yazdanbakhsh M.
Immunological Reviews, 171:125-147, 1999
A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases   
Zang X, Yazdanbakhsh M, Jiang HB, Kanost MR, Maizels RM.
Blood, 94:1418-1428, 1999

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