Selected Publications

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function    

Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X.
Proceedings of the National Academy of Sciences USA, in press, 2013
 

Curcumin improves the therapeutic efficacy of Listeria-Mage-b vaccine in correlation with improved T cell responses in blood of a triple negative breast cancer model 4T1    

Singh M, Ramos L, Asafu-Adjei D, Quispe-Tintaya W, Chandra D, Jahangir A, Zang X, Aggarwal BB, Gravekamp C
Cancer Medicine, in press, 2013
 

B7x(B7-H4/B7S1) and myeloid derived suppressor cells in the tumor microenvironment: A tale of two cities    

Jeon H, Ohaegbulam KC, Abadi YM, Zang X.
OncoImmunology, in press, 2013
 

Structure and T cell coinhibition properties of B7 family member B7-H3    

Vigdorovich V, Ramagopal U, Lazar-Molnar E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC.
Structure, in press, 2013
 

Host B7x promotes pulmonary metastasis of breast cancer    

Abadi YM, Jeon H, Ohaegbulam KC, Scandiuzzi L, Ghosh K, Hofmeyer KA, Lee JS, Ray A, Gravekamp C, Zang X.
The Journal of Immunology, 190:3806-3814, 2013
 

T cell coinhibition and immunotherapy in human breast cancer    

Janakiram M, Abadi YM, Sparano JA, Zang X.
Discovery Medicine, 14:229-236, 2012
 

B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells    

Lee JS, Scandiuzzi L, Ray A, Wei J, Hofmeyer KA, Abadi MY, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X.
The Journal of Immunology, 189:4165-4174, 2012
 

The B7 and CD28 families (Book chapter)

Zang X.
Encyclopedia of Medical Immunology, I.R.Mackay and N.R. Rose, ed. Springer, 2012
 

Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection    

Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X.
The Journal of Immunology, 189:3054-3063, 2012
 

T cell costimulation and coinhibition: Genetics and disease (Review)   

Scandiuzzi L, Ghosh K, Zang X.
Discovery Medicine, 12:119-128, 2011
 

The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion (Review)   

Hofmeyer KA, Jeon H, Zang X.
Journal of Biomedicine and Biotechnology, 2011:451694, 2011
 

Tissue specific expression of B7x protects from CD4 T cell mediated autoimmunity   

Wei J, Loke P, Zang X*, Allison JP*.
(* Co-corresponding authors)
Journal of Experimental Medicine, 208:1683-1694, 2011
 

T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics (Review)   

Barach YS, Lee JS, Zang X.
Trends in Molecular Medicine, 17:47-55, 2011
 

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas   

Zang X, Sullivan PS, Soslow RA, Waitz R, Reuter VE, Wilton A, Thaler HT, Arul M, Slovin SF, Wei J, Spriggs DR, Dupont J, Allison JP.
Modern Pathology, 23:1104-1112, 2010
 

Mouse Mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.   

Scandiuzzi L, Beghdadi W, Daugas E, Abrink M, Tiwari N, Brochetta C, Claver J, Arouche N, Zang X, Pretolani M, Monteiro RC, Pejler G, Blank U.
The Journal of Immunology, 185:624-633, 2010
 

The contrasting role of B7-H3 (Commentary)   

Hofmeyer KA, Ray A, Zang X.
Proceedings of the National Academy of Sciences USA, 105: 10277-10278, 2008
 

Serum soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage   

Thompson RH*, Zang X*, Lohse CM, Leibovich BC, Slovin S, Reuter VE, Blute ML, Russo P, Kwon ED*, Allison JP*.
(*Contributed equally)
Cancer Research, 68: 6054-6058, 2008
 

The B7 family and cancer therapy: Costimulation and coinhibition (Review)   

Zang X, Allison JP.
Clinical Cancer Research, 13: 5271-5279, 2007
 

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome   

Zang X*, Thompson RH*, Al-Ahamadie A, Serio AM, Reuter VE, Eastham JA, Scardino PT, Sharma P, Allison JP.
(*Contributed equally)
Proceedings of the National Academy of Sciences USA, 104: 19458-19463, 2007
 

T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface   

Cao E*, Zang X*, Ramagopal UA*, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, DiLorenzo TP, Allison JP, Nathenson SG, Almo SC.
(*Contributed equally)
Immunity, 26: 311-321, 2007
 

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic Infection    

Loke P, Gallagher I, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP, Allen JE.
Journal of Immunology, 179: 3926-3936, 2007
 

To be or not to be B7 (Commentary)   

Zang X, Allison JP.
Journal of Clinical Investigation, 116: 2590-2593, 2006
 

A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors   

Zang X, Loke P, Kim J, Wojnoonski K, Kusdra L, Allison JP.
Genomics, 88: 841-845, 2006
 

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection    

Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen IE, Allison JP.
Proceedings of the National Academy of Sciences USA, 102: 9872-9877, 2005
 

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1   

Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM.
Nature Immunology, 4:670-679, 2003
 

B7x: A widely expressed B7 family member that inhibits T cell activation   

Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP.
Proceedings of the National Academy of Sciences USA, 100: 10388-10392, 2003
 

Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi   

Emes R, Thompson F, Moore J, Zang X, Devaney E.
International Journal for Parasitology, 32:415-424, 2002
 

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure   

Zang X, Taylor P, Wang JM, Meyer DJ, Scott AL, Walkinshaw MD, Maizels RM.
Journal of Biological Chemistry, 277:44261-44267, 2002
 

A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection   

Falcone FH, Loke P, Zang X, MacDonald AS, Maizels RM, Allen JE.
Journal of Immunology, 167: 5348-5354, 2001
 

Immune evasion genes from filarial nematodes (Review)    

Maizels RM, Gomez-Escobar N, Gregory WF, Murray J, Zang X.
International Journal for Parasitology, 31:889-898, 2001
 

Serine proteinase inhibitors from nematodes and the arms race between host and pathogen (Review)   

Zang X, Maizels RM.
Trends in Biochemical Sciences, 26:191-197, 2001
 

The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans    

Zang X, Atmadia KA, Gray P, Allen JE, Gray CA, Lawrence RA, Yazdanbakhsh M, Maizels RM.
Journal of Immunology, 165:5161-5169, 2000
 

Vaccination against helminth parasites: the ultimate challenge for vaccinologists? (Review)   

Maizels RM, Holland M, Falcone F, Zang X, Yazdanbakhsh M.
Immunological Reviews, 171:125-147, 1999
 

A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases   

Zang X, Yazdanbakhsh M, Jiang HB, Kanost MR, Maizels RM.
Blood, 94:1418-1428, 1999