brian.weinrick at einstein.yu.edu
The focus of my research is the problem of persistence in Mycobacterium tuberculosis. This is the set of attributes that allow the bacterium to survive killing by drugs despite lacking alleles that code for genotypic drug resistance. The phenomenon of persistence may be the basis of the need for lengthy treatment regimens to cure tuberculosis and could also contribute the ability of the bacteria to establish a latent infection.
in press at Nature Chemical Biology:
Self-Poisoning of Mycobacterium tuberculosis by Inhibition of GlgE Reveals a New Class of Drug Target
Rainer Kalscheuer, Karl Syson, Usha Veeraraghavan, Brian Weinrick, Karolin E. Biermann, Feng Wang, James C. Sacchettini, Gurdyal Besra, Stephen Bornemann, and William R. Jacobs, Jr.
Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.
Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Hewinson RG, Vordermeier HM, Barnes SW, Federe GC, Walker JR, Glynne RJ, Hsu T, Weinrick B, Biermann K, Larsen MH, Jacobs WR Jr.
Vaccine. 2009 Feb 18;27(8):1201-9. Epub 2009 Jan 9.
PMID: 19135497 [PubMed - indexed for MEDLINE]