Stable Isotope & Metabolomics Core


  1. Y. Qiu et al., Isotopic Ratio Outlier Analysis (IROA) of the S. cerevisiae metabolome using accurate mass GC-TOF/MS: A new method for discovery. Analytical Chemistry, (2015) Accepted manuscript
  2. X. Liu et al., The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Cell Reports 13, 2219-2231 (2015).
  3. N. Bonhoure et al., Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes & Development 29, 934-947 (2015).
  4. W. Brima et al., The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice. Diabetes-Metabolism Research and Reviews 31, 346-359 (2015).
  5. P. O. Broin et al., Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury. International Journal of Radiation Oncology Biology Physics 91, 360-367 (2015).
  6. J. Jao et al., Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon. Journal of Clinical Endocrinology & Metabolism100, 3260-3269 (2015).
  7. I. J. Kurland et al., Integrative Metabolic Signatures for Hepatic Radiation Injury. Plos One 10, (2015).
  8. J. Miao et al., Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. Journal of Lipid Research 55, 659-667 (2014).
  9. R. A. Haeusler et al., Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nature Communications 5, (2014).
  10. K. Nowak et al., Metabolomics Profiles Suggest a Mechanism for Caloric Restriction-Induced Radiation Sensitivity. International Journal of Radiation Oncology Biology Physics 90, S176-S177 (2014).
  11. B. Vaitheesvaran et al., Role of the tumor suppressor IQGAP2 in metabolic homeostasis: possible link between diabetes and cancer. Metabolomics 10, 920-937 (2014).
  12. E. S. Kim, F. Isoda, I. Kurland, C. V. Mobbs, Glucose-Induced Metabolic Memory in Schwann Cells: Prevention by PPAR Agonists. Endocrinology 154, 3054-3066 (2013).
  13. I. J. Kurland et al., Application of combined omics platforms to accelerate biomedical discovery in diabesity. Annals Meeting Reports. (2013), vol. 1287, pp. 1-16.
  14. G. Laurent et al., SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase. Molecular Cell 50, 686-698 (2013).
  15. Y. J. Yang et al., Alteration of De Novo Glucose Production Contributes to Fasting Hypoglycaemia in Fyn Deficient Mice. Plos One 8, (2013).
  16. B. Vaitheesvaran et al., Peripheral Effects of FAAH Deficiency on Fuel and Energy Homeostasis: Role of Dysregulated Lysine Acetylation. Plos One 7, (2012).
  17. X. P. Zhao et al., Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. Journal of Clinical Investigation 122, 2417-2427 (2012).
  18. J. T. Haas et al., Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression. Cell Metabolism 15, 873-884 (2012).
  19. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1 J Clin Invest. 122(7):2417-27 (2012).
  20. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression Cell Metab. 15(6):873-84 (2012).
  21. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.
    Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, Sun Y, Yang ES, Liu LP, Vaitheesvaran B, Bridges L, Kurland IJ, Strich R, Ni JQ, Wang C, Ericsson J, Pessin JE, Ji JY, Yang F.
    J Clin Invest. 2012 Jul 2;122(7):2417-27. doi: 10.1172/JCI61462. Epub 2012 Jun 11.

    PMID: 22684109 [PubMed - indexed for MEDLINE] Free PMC Article
    Related citations 

  22. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
    Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV Jr, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB.
    Cell Metab. 2012 Jun 6;15(6):873-84.

    PMID: 22682225
    Related citations 

  23. Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation.
    Vaitheesvaran B, Yang L, Hartil K, Glaser S, Yazulla S, Bruce JE, Kurland IJ.
    PLoS One. 2012;7(3):e33717. Epub 2012 Mar 19.

    PMID: 22442717 [PubMed - indexed for MEDLINE] Free PMC Article>
    Related citations 

  24. Advantages of tandem LC-MS for the rapid assessment of tissue-specific
    metabolic complexity using a pentafluorophenylpropyl stationary phase.

    Lv H, Palacios G, Hartil K, Kurland IJ.
    J Proteome Res. 2011 Apr 1;10(4):2104-12. Epub 2011 Mar 7.

    PMID: 21322650 [PubMed - indexed for MEDLINE]

  25. MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity.
    Vaitheesvaran B, LeRoith D, Kurland IJ.
    Diabetologia. 2010 Oct;53(10):2224-32. Epub 2010 Jun 25.

    PMID: 20577711 [PubMed - indexed for MEDLINE]

  26. Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes.
    Vaitheesvaran B, Chueh FY, Xu J, Trujillo C, Saad MF, Lee WN, McGuinness OP, Kurland IJ.
    Metabolomics. 2010 Jun;6(2):180-190. Epub 2009 Nov 12.

    PMID: 20445758 [PubMed]

  27. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
    Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW,
    Espinosa JM, Mostoslavsky R.
    Cell. 2010 Jan 22;140(2):280-93.

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