Mouse Cardiac Surgery and Physiology Core

Overview

The Mouse Cardiac Surgery and Physiology Core supports Einstein investigators in delineating the impact of genes, drugs and metabolites on cardiac function. The core employs multiple approaches to analyze cardiovascular structure and function in wild-type and genetically manipulated mice. The technically experienced staff of the core performs the analyses and provides the data to the investigator. When possible, training is also offered. Contact core staff to determine the availability of new surgical and measurement services being developed.

Services

  • Procedures/measurements currently offered:
    • Myocardial ischemia-reperfusion to induce myocardial infarction in vivo
    • Permanent coronary artery occlusion to induce myocardial infarction in vivo
    • Quantification of myocardial infarction size
    • Echocardiography (M-mode and two-dimensional) for cardiac chamber size, wall thickness and function
    • Insertion of arterial (e.g., carotid) and venous (e.g., jugular) catheters for blood pressure and drug Infusion
    • Tail vein injections
    • Implantation of osmotic minipumps for drug infusion (e.g., Alzet)

Location and Contacts

Mouse Cardiac Surgery and Physiology Core

Forchheimer G45

 
 
 

Scientific Director
Nikolaos G. Frangogiannis, M.D.
718.430.3546
nikolaos.frangogiannis@einstein.yu.edu

Operations Director
Zhiping (David) Wu, M.D.
718.430.4141
zhiping.wu@einstein.yu.edu