Proteomics (LMAP)

Overview

The Proteomics Facility, supported by the Laboratory for Macromolecular Analysis and Proteomics (LMAP), provides Einstein researchers with a comprehensive mass spectrometry resource for analysis of proteins, peptides and other selected families of biomolecules. Expert staff scientists are available to help plan and execute a successful proteomics based analysis. They also assist in data analysis, including statistics and data visualization.

Services

Protein-related studies:

  • Identification and quantification of purified proteins and/or complex proteomes (label-free, SILAC, isobaric tagging)
  • Determination of protein-protein interactions and protein-nucleic acid interactions
  • Computational determination of regulated protein pathways, complexes and other networks
  • Identification and quantification of protein post-translational modifications
  • Mapping of protein and proteome localization in the cell, in particular chromatin complexes
  • High throughput analysis (100s samples per day) of histone post-translational modifications
  • Determination of protein synthesis rate (turnover) as complementary quantitative dimension of protein abundance
  • Preliminary data analysis, including time-series statistics and assistance in biomarker selection


Other biomolecules:

  • Spatial localization of molecules by imaging (in situ) mass spectrometry
  • Confirmation of synthetic and recombinant molecules
  • High-resolution analysis of metabolites, drugs, peptides and other small molecules
  • Targeted assays and pharmacokinetics

 

Location and Contacts

Proteomics (LMAP)

Ullmann 403

 
 
 

Interim Scientific Director
Steven C. Almo, Ph.D.
718.430.2746
steve.almo@einstein.yu.edu

Associate Scientific Director
Louis M. Weiss, M.D., M.P.H.
718.430.2142
louis.weiss@einstein.yu.edu

Operations Director
Edward Nieves
718.430.3476
edward.nieves@einstein.yu.edu