Research Roundup

Early Programming of Childhood Obesity—More than one-third of U.S. children are classified as overweight or obese. Studies show that children born underweight are at higher risks for obesity, cardiovascular disease, and type 2 diabetes. Researchers believe that one cause of obesity involves changes in the nongenetic (i.e., epigenetic) influences on gene expression—in particular, changes in the pattern of DNA methylation. The Eunice Kennedy Shriver National Institute of Child Health & Human Development has awarded Maureen Charron, Ph.D., and Mamta Fuloria, M.B.B.S., a five-year, $3.4 million grant to study DNA methylation of blood cells of intrauterine growth restricted infants, who are at high risk for becoming obese. More specifically, Drs. Charron and Fuloria will examine the children’s blood at birth and at age two to determine how DNA methylation has affected their CD3+ T-cells--immune cells that plays a key role in the development of obesity. Dr. Charron is professor of biochemistry, of medicine, and of obstetrics & gynecology and women's health at Einstein. Dr. Fuloria is an associate professor of pediatrics at Einstein. (1R01HD092533-01A1)

Friday, April 20, 2018