Laboratory of John Condeelis, Ph.D.


From over 250 

Smirnova, T., Zhou, Z.N., Flinn, R.J., Wyckoff, J., Boimel, P.J., Pozzuto, M., Coniglio, S.J., Backer, J.M., Bresnick, A.R., Condeelis, J.S., Hynes, N.E., and Segall, J.E. (2012). Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene 31, 706-715.  

Raja, W.K., Padgen, M.R., Williams, J.K., Gertler, F.B., Wyckoff, J.B., Condeelis, J.S., and Castracane, J. (2012). Development Path and Current Status of the NANIVID:  A New Device for Cancer Cell Studies. Journal of Micro/Nanolithography, MEMS, and MOEMS (JM3) 11, 0130131-0130139.  

Oktay, M.H., Gertler, F.B., Liu, Y.F., Rohan, T.E., Condeelis, J.S., and Jones, J.G. (2012). Correlated immunohistochemical and cytological assays for the prediction of hematogenous dissemination of breast cancer. J Histochem Cytochem 60, 168-173.  

Gligorijevic, B., Wyckoff, J., Yamaguchi, H., Wang, Y., Roussos, E.T., and Condeelis, J. (2012). N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci 125, 724-734.  

Bravo-Cordero, J.J., Hodgson, L., and Condeelis, J. (2012). Directed cell invasion and migration during metastasis. Curr Opin Cell Biol 24, 277-283. [PMCID PMC3320684] 

Bragado, P., Sosa, M.S., Keely, P., Condeelis, J., and Aguirre-Ghiso, J.A. (2012). Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res 195, 25-39.  

Boimel, P.J., Smirnova, T., Zhou, Z.N., Wyckoff, J., Park, H., Coniglio, S.J., Qian, B.Z., Stanley, E.R., Cox, D., Pollard, J.W., Muller, W.J., Condeelis, J., and Segall, J.E. (2012). Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Res 14, R23.  

Bravo-Cordero, J.J., Oser, M., Chen, X., Eddy, R., Hodgson, L., and Condeelis, J. (2011). A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol 21, 635-644. [PMCID PMC3081966] 

Dovas, A., Gligorijevic, B., Chen, X., Entenberg, D., Condeelis, J., and Cox, D. (2011). Visualization of actin polymerization in invasive structures of macrophages and carcinoma cells using photoconvertible beta-actin-Dendra2 fusion proteins. PLoS One 6, e16485. [PMCID PMC3038862] 

Entenberg, D., Wyckoff, J., Gligorijevic, B., Roussos, E.T., Verkhusha, V.V., Pollard, J.W., and Condeelis, J. (2011). Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc 6, 1500-1520.  

Gertler, F., and Condeelis, J. (2011). Metastasis: tumor cells becoming MENAcing. Trends Cell Biol 21, 81-90.  

Hernandez, L., Magalhaes, M.A., Coniglio, S.J., Condeelis, J.S., and Segall, J.E. (2011). Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res 13, R128. [PMCID PMC3326570] 

Mader, C.C., Oser, M., Magalhaes, M.A., Bravo-Cordero, J.J., Condeelis, J., Koleske, A.J., and Gil-Henn, H. (2011). An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res 71, 1730-1741. [PMCID PMC3057139] 

Magalhaes, M.A., Larson, D.R., Mader, C.C., Bravo-Cordero, J.J., Gil-Henn, H., Oser, M., Chen, X., Koleske, A.J., and Condeelis, J. (2011). Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. J Cell Biol 195, 903-920. [PMCID PMC3257566] 

Oser, M., Dovas, A., Cox, D., and Condeelis, J. (2011). Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. Eur J Cell Biol 90, 181-188. [PMCID PMC3017226] 

Roussos, E.T., Balsamo, M., Alford, S.K., Wyckoff, J.B., Gligorijevic, B., Wang, Y., Pozzuto, M., Stobezki, R., Goswami, S., Segall, J.E., Lauffenburger, D.A., Bresnick, A.R., Gertler, F.B., and Condeelis, J.S. (2011). Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci 124, 2120-2131. [PMCID PMC3113666] 

Roussos, E.T., Condeelis, J.S., and Patsialou, A. (2011). Chemotaxis in cancer. Nat Rev Cancer 11, 573-587.  

Roussos, E.T., Goswami, S., Balsamo, M., Wang, Y., Stobezki, R., Adler, E., Robinson, B.D., Jones, J.G., Gertler, F.B., Condeelis, J.S., and Oktay, M.H. (2011). Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis 28, 515-527.  

Sampaio, N.G., Yu, W., Cox, D., Wyckoff, J., Condeelis, J., Stanley, E.R., and Pixley, F.J. (2011). Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion. J Cell Sci 124, 2021-2031. [PMCID PMC3104034] 

Shapiro, I.M., Cheng, A.W., Flytzanis, N.C., Balsamo, M., Condeelis, J.S., Oktay, M.H., Burge, C.B., and Gertler, F.B. (2011). An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet 7, e1002218. [PMCID PMC3158048] 

Subach, O.M., Patterson, G.H., Ting, L.M., Wang, Y., Condeelis, J.S., and Verkhusha, V.V. (2011). A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nat Methods 8, 771-777. [PMCID PMC3164916] 

Tania, N., Prosk, E., Condeelis, J., and Edelstein-Keshet, L. (2011). A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells. Biophys J 100, 1883-1892. [PMCID PMC3077689] 

Wyckoff, J., Gligorijevic, B., Entenberg, D., Segall, J., and Condeelis, J. (2011). The in vivo invasion assay: preparation and handling of collection needles. Cold Spring Harb Protoc 2011, 1232-1234.  

Wyckoff, J., Gligorijevic, B., Entenberg, D., Segall, J., and Condeelis, J. (2011). High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harb Protoc 2011, 1167-1184.  

Condeelis, J., and Weissleder, R. (2010). In vivo imaging in cancer. Cold Spring Harb Perspect Biol 2, a003848.  

Isaac, B.M., Ishihara, D., Nusblat, L.M., Gevrey, J.C., Dovas, A., Condeelis, J., and Cox, D. (2010). N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis. Exp Cell Res 316, 3406-3416. [PMCID PMC2976787] 

Liu, H., Patel, M.R., Prescher, J.A., Patsialou, A., Qian, D., Lin, J., Wen, S., Chang, Y.F., Bachmann, M.H., Shimono, Y., Dalerba, P., Adorno, M., Lobo, N., Bueno, J., Dirbas, F.M., Goswami, S., Somlo, G., Condeelis, J., Contag, C.H., Gambhir, S.S., and Clarke, M.F. (2010). Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A 107, 18115-18120. [PMCID PMC2964232] 

Ojalvo, L.S., Whittaker, C.A., Condeelis, J.S., and Pollard, J.W. (2010). Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol 184, 702-712. [PMCID PMC3226722] 

Oser, M., Mader, C.C., Gil-Henn, H., Magalhaes, M., Bravo-Cordero, J.J., Koleske, A.J., and Condeelis, J. (2010). Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci 123, 3662-3673. [PMCID PMC3037016] 

Raja, W.K., Gligorijevic, B., Wyckoff, J., Condeelis, J.S., and Castracane, J. (2010). A new chemotaxis device for cell migration studies. Integr Biol (Cam) 2, 696-706.  

Roussos, E.T., Keckesova, Z., Haley, J.D., Epstein, D.M., Weinberg, R.A., and Condeelis, J.S. (2010). AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res 70, 7360-7364.  

Roussos, E.T., Wang, Y., Wyckoff, J.B., Sellers, R.S., Wang, W., Li, J., Pollard, J.W., Gertler, F.B., and Condeelis, J.S. (2010). Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res 12, R101. [PMCID PMC3046446] 

Cammer, M., Gevrey, J.C., Lorenz, M., Dovas, A., Condeelis, J., and Cox, D. (2009). The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42. J Biol Chem 284, 23302-23311. [PMCID PMC2749104] 

Desmarais, V., Yamaguchi, H., Oser, M., Soon, L., Mouneimne, G., Sarmiento, C., Eddy, R., and Condeelis, J. (2009). N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskeleton 66, 303-316. [PMCID PMC2747479] 

Gligorijevic, B., and Condeelis, J. (2009). Stretching the timescale of intravital imaging in tumors. Cell Adh Migr 3, 313-315. [PMCID PMC2802736] 

Gligorijevic, B., Kedrin, D., Segall, J.E., Condeelis, J., and van Rheenen, J. (2009). Dendra2 photoswitching through the Mammary Imaging Window. J Vis Exp. [PMCID PMC2794883] 

Goswami, S., Philippar, U., Sun, D., Patsialou, A., Avraham, J., Wang, W., Di Modugno, F., Nistico, P., Gertler, F.B., and Condeelis, J.S. (2009). Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 26, 153-159. [PMCID PMC3042857] 

Hernandez, L., Smirnova, T., Wyckoff, J., Condeelis, J., and Segall, J.E. (2009). In vivo assay for tumor cell invasion. Methods Mol Biol 571, 227-238. [PMCID PMC3156574] 

Leyman, S., Sidani, M., Ritsma, L., Waterschoot, D., Eddy, R., Dewitte, D., Debeir, O., Decaestecker, C., Vandekerckhove, J., van Rheenen, J., Ampe, C., Condeelis, J., and Van Troys, M. (2009). Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering. Mol Biol Cell 20, 4509-4523. [PMCID PMC2770939] 

Oser, M., and Condeelis, J. (2009). The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem 108, 1252-1262.  

Oser, M., Yamaguchi, H., Mader, C.C., Bravo-Cordero, J.J., Arias, M., Chen, X., Desmarais, V., van Rheenen, J., Koleske, A.J., and Condeelis, J. (2009). Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol 186, 571-587. [PMCID PMC2733743] 

Pang, H., Flinn, R., Patsialou, A., Wyckoff, J., Roussos, E.T., Wu, H., Pozzuto, M., Goswami, S., Condeelis, J.S., Bresnick, A.R., Segall, J.E., and Backer, J.M. (2009). Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res 69, 8868-8876. [PMCID PMC2793177] 

Patsialou, A., Wyckoff, J., Wang, Y., Goswami, S., Stanley, E.R., and Condeelis, J.S. (2009). Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res 69, 9498-9506. [PMCID PMC2794986] 

Robinson, B.D., Sica, G.L., Liu, Y.F., Rohan, T.E., Gertler, F.B., Condeelis, J.S., and Jones, J.G. (2009). Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res 15, 2433-2441. [PMCID PMC3156570] 

van Rheenen, J., Condeelis, J., and Glogauer, M. (2009). A common cofilin activity cycle in invasive tumor cells and inflammatory cells. J Cell Sci 122, 305-311. [PMCID PMC2772875] 

Yip, S.C., Eddy, R.J., Branch, A.M., Pang, H., Wu, H., Yan, Y., Drees, B.E., Neilsen, P.O., Condeelis, J., and Backer, J.M. (2008). Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. Biochem J 411, 441-448. [PMCID PMC2915465] 

Sarmiento, C., Wang, W., Dovas, A., Yamaguchi, H., Sidani, M., El-Sibai, M., Desmarais, V., Holman, H.A., Kitchen, S., Backer, J.M., Alberts, A., and Condeelis, J. (2008). WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. J Cell Biol 180, 1245-1260. [PMCID PMC2290849] 

Rodriguez, A.J., Czaplinski, K., Condeelis, J.S., and Singer, R.H. (2008). Mechanisms and cellular roles of local protein synthesis in mammalian cells. Curr Opin Cell Biol 20, 144-149. [PMCID PMC2404115] 

Philippar, U., Roussos, E.T., Oser, M., Yamaguchi, H., Kim, H.D., Giampieri, S., Wang, Y., Goswami, S., Wyckoff, J.B., Lauffenburger, D.A., Sahai, E., Condeelis, J.S., and Gertler, F.B. (2008). A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 15, 813-828. [PMCID PMC2637261] 

Kedrin, D., Gligorijevic, B., Wyckoff, J., Verkhusha, V.V., Condeelis, J., Segall, J.E., and van Rheenen, J. (2008). Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods 5, 1019-1021. [PMCID PMC2820719] 

Frantz, C., Barreiro, G., Dominguez, L., Chen, X., Eddy, R., Condeelis, J., Kelly, M.J., Jacobson, M.P., and Barber, D.L. (2008). Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J Cell Biol 183, 865-879. [PMCID PMC2592832] 

El-Sibai, M., Pertz, O., Pang, H., Yip, S.C., Lorenz, M., Symons, M., Condeelis, J.S., Hahn, K.M., and Backer, J.M. (2008). RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res 314, 1540-1552. [PMCID PMC2677995] 


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