Laboratory of John Condeelis, Ph.D.


 From Over 290 

Szulczewski, J.M., Inman, D.R., Entenberg, D.E., Ponik, S.M., Aguirre-Ghiso, J.,  Castracane, J., Condeelis, J.S., Eliceiri, K.E., & Keely, P.J. (2016) In vivo visualization of stromal macrophages via label-free FLIM-based metabolite imaging. In Press  

Rodriguez-Tirado, C., Kitamura, T., Kato, Y., Pollard, J.W., Condeelis, J.S., and Entenberg, D.E. (2016) Long-term high-resolution intravital microscopy in the lung with a vacuum stabilized imaging window. Journal of Visualized Experiments.  In Press  

 Williams, J.K, Entenberg, D.E., Wang, Y, Avivar-Valderase, A, Padgena, M, Clark, A, Aguirre-Ghiso, J.A, Castracane, J, and Condeelis, J.S. (2016) Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging. Intravital. In Press  

Harney, A.S., Entenberg, D.E., Wang, Y and Condeelis, J.S. (2016) Extended time-lapse intravital imaging of real-time multicellular dynamics in the tumor microenvironment. Journal of Visualized Experiments. In Press  

Karagiannis, G.S, Goswami, S., Jones, J.G., Oktay, M.H., and Condeelis, J.S (2016) Signatures of breast cancer metastasis at a glance. Journal of Cell Science. 129, 1751-1758. PMID: 27084578 

Khalil, B.D., Hsueh, C., Cao, Y., Abi Saab, A.F., Wang, Y., Condeelis, J.S., Bresnick, A.R., and Backer, J.B. (2016) GPCR signaling mediates tumor metastasis via PI3Kβ. Cancer Research.  PMID: 27013201   

Harney, A.S., Entenberg, D.E., Wang, Y and Condeelis, J.S. (2015) Extended time-lapse intravital imaging of real-time multicellular dynamics in the tumor microenvironment. JoVe. In Press.   

 Carmona, G., Perera, U., Gillett, C., Naba1, A., Law, A-L., Sharma, V.P., Wang, J., Wyckoff, J., Balsamo, M., Mosis, F., De Piano, M., Monypenny, J., Woodman, N., McConnell, R.E., Mouneimne, G., Van Hemelrijck, M., Cao, Y., Condeelis, J., O. Hynes, R., Gertler, F.B., and Krause, M. (2016) Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene.1-8 PMID: 26996666   

Entenberg, D., Rodriguez-Tirado, C., Kato, Y., Kitamura, T., Pollard, J.W and Condeelis, J. (2015) In vivo subcellular resolution optical imaging in the lung reveals early metastatic proliferation and motility. IntraVital. 2015 August 15; 4(3):1-11. [NIHMSID: NIHMS755228] 

Knutsdottir, H., Condeelis, J.S. and Palsson, E. (2015) 3-D individual cell based computational modeling of tumor cell-macrophage paracrine signaling mediated by EGF and CSF-1 gradients. Integr Biol (Camb). 2016 Jan 18;8(1):104-19. Epub 2015 Dec 21 [PMID: 26686751] 

Oudin, M.J., Hughes, S.K., Rohani, N., Moufarrej, M.N., Jones J.G., Condeelis, J.S., Lauffenburger D.A., Gertler, F.B. (2015) Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression. Clinical & experimental metastasis.  [PMID: 26680363] 

Sung Jun Lim, S.J., Zahid, M.U., Le, P., Ma, L., Entenberg, D., Harney, A.S., Condeelis, J., and Smith, A.M. (2015) Brightness-Equalized Quantum Dots. Nat Commun. 2015 Oct 5;6:8210. [PMCID:PMC4594210] 

Hughes, S.K., Oudin, M.J., Tadros, J., Neil, J., Del Rosario, A., Joughin, B.A., Ritsma, L., Wyckoff, J., Vasile, E., Eddy, R., Philippar, U., Lussiez, A., Condeelis, J.S., van Rheenen, J., White, F., Lauffenburger, D.A., and Gertler, F.B. (2015) PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Mol Biol Cell. 2015 26:21 3867-78. PMID: 26337385 

Harney, A.S., Arwert, E.N., Entenberg, D., Wang, Y., Guo, P., Qian, B-Z., Oktay, M.,  Pollard, J.W., Jones, J.G., and Condeelis, J.S. (2015) Real-time imaging reveals local, transient vascular permeability and tumor cell intravasation stimulated by Tie2Hi macrophage-derived VEGFA. Cancer Discovery. 2015 Sept; 5(9):932-43. [PMCID: PMC4560669] 

Jimenez, L., Sharma, V.P., Condeelis, J., Harris, T., Ow, T.J., Prystowsky, M.B., Childs, G., and Segall, J.E. (2015) . MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma. Arch Pathol Lab Med.  2015 Jul 14. [PMID: 26172508] 

Forse, C.L., Agarwal, S., Pinnaduwage, D., Gertler, F., Condeelis, J., Lin, J., Xue, X., Johung, K., Mulligan, A.M., Rohan, T., Bull, S.B., and Andrulis, I.L. (2015) Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary 4 node-negative breast cancer. BMC Cancer. 2015 Jun 27;15:483. [PMCID: PMC4482190] 

Zolla V, Nizamutdinova IT, Scharf B, Clement CC, Maejima D, Akl T, Nagai T, Luciani P, Leroux JC, Halin C, Stukes S, Tiwari S, Casadevall A, Jacobs WR Jr, Entenberg D, Zawieja DC, Condeelis J, Fooksman DR, Gashev AA, and Santambrogio L. (2015) Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging Cell. 2015 May 15. [PMCID: PMC4531072] 

Valenzuela-Iglesias A., Bravo-Cordero J.J., Sharma V.P., Beaty B.T., Gutierrez-Millan L.E., Ding Z., Roy P., and Condeelis, J. (2014) Profilin 1 regulates invadopodium maturation in human breast cancer cells.  Eur J Cell Biol. 2015 Feb;94(2):78-89. [PMCID: PMC4322761] 

Pignatelli, J., Goswami, S., Jones, J., Rohan, T., Pieri, E., Chen, X., Adler, E., Maleki, S., Bresnick, A., Gertler, F., Condeelis, J., and Oktay, M. (2014) Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV-and Macrophage-Dependent Transendothelial Migration. Science Signaling. 7(353):1-12. [PMCID: PMC4266931] 

Weitsman, G., Lawler, K., Kelleher, M., Barrett, J., Barber, P., Shamil, E., Festy, F., Patel, G., Fruhwirth, G., Huang, L., Tullis, I., Woodman, N., Ofo, E., Ameer-Beg, S., Irshad, S., Condeelis, J., Gillett, C., Ellis, P., Vojnovic, B., Coolen, A., and Ng, T. (2014) Imaging tumour heterogeneity of the consequences of a PKCα–substrate interaction in breast cancer patients. Biochem. Soc. Trans. 1;42(6):1498-505. [PMCID: PMC4259014] 

Beaty, B.T. and Condeelis, J. (2014) Digging a little deeper: the stages of invadopodium formation and maturation. Eur. J. of Cell Biol. [PMCID: PMC4262566] 

Patsialou, A., Wang, Y., Pignatelli, J., Chen, X., Entenberg, D., Oktay, M. and Condeelis, J.C. (2014) Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFβ in claudin-low breast tumor cells.  Oncogene. [PMCID: PMC4317382] 

Patsialou, A. and Condeelis, J. (2014) Metastatic cells: moving onco-targets. Oncotarget. 5(11):3424-5. [PMCID: PMC4116491] 

Beaty B.T., Wang Y., Bravo-Cordero J.J., Sharma V, Miskolci V., Hodgson L., and Condeelis, J. (2014) Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. J. Cell Biol. 205(5):737-51. [PMCID: PMC4050723]

Bergman, A., Condeelis, J. and Gligorijevic, B. (2014) Invadopodia in context.  Cell Adhesion & Migration. 8(3):273-279.  [PMCID: PMC4198352] 

Bravo-Cordero, J.J., Hodgson, L. and Condeelis, J. (2014) Spatial regulation of tumor cell protrusions by RhoC. Cell Adh. Migr.  8(2) 263-267.[PMCID: PMC4198350] 

Rohan, T.E., Xue, X., Lin, H-M., Lin, D’Alfonso, T.M., Ginter, P.G, Oktay, M.H., Robinson, B.D., Ginsberg, M., Gertler, F.B., Glass, A.G., Sparano, J.A., Condeelis, J., and Jones, JG. (2014) Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer. J Natl Cancer Inst. 106(8). [PMCID: PMC4133559] 

Kwon, M., Lee, S.J., Wang, Y., Rybak, Y., Luna, A., Reddy, S., Adem, A., Beaty, B.T., Condeelis, J. and Libutti, S.K. (2014) Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis. International Journal of Cancer. 135(1):48-60. DOI: 10.1002/ijc.28662. [PMCID: PMC3991758] 

Sharma, V., Beaty, B., Cox, D., Condeelis, J. and Eddy, R. (2014) An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.  Methods Mol. Biol.  1172:115-23. Chapter 10 Vol. 1172. [PMCID: PMC4124813/NIHMSID # 605152] 

Gligorijevic, B., Bergman, A. and Condeelis, J. (2014) Multiparametric classification links tumor microenvironments with tumor cell phenotype. PLoS Biol.  12(11) e1001995. [PMCID: PMC4227649]

Moshfegh, Y., Bravo-Cordero, J.J., Miskolci, V., Condeelis, J., and Hodgson, L. (2014) A Trio-Rac1-PAK1 signalling axis drives invadopodia disassembly. Nature Cell Biol. 16(6):574-86. Reference number: NCB-H24591A; R1. [PMCID: PMC4083618]  

Roh-Johnson, M., Bravo-Cordero, J.J., Patsialou, A.P., Sharma, V.P., Guo P., Liu, H., Hodgson, L., and Condeelis, J. (2014) Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation. Oncogene. 33(33):4203-12. doi:10.1038/onc.2013.377. [PMCID: PMC3962803] 

Zhou, Z., Sharma, V., Beaty, B., Roh-Johnson, M., Peterson E.A., van Rooijen, N., Kenny, P., Wiley, HS., Condeelis, J. and Segall, J. (2014) Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo. Oncogene. DOI: 10.1038/onc.2013.363. [PMCID: PMC3950352] 

Ding, Z., Joy, M., Bhargava, R., Gunsaulus, M., Lakshman, N., Miron-Mendoza, M., Petroll, M., Condeelis, J., Wells, A., and Roy, P. (2014) Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. Oncogene. 33(16):2065-74. doi: 10.1038/onc.2013.166.   [PMCID: PMC3834125]

Tania, N., Condeelis, J., and Edelstein-Keshet, L. (2013) Modeling the synergy of cofilin and Arp2/3 in lamellipodial protrusive activity. Biophys. J. 105(9):1946-55. [PMCID: PMC3824550]  

Stadler, S.C., Vincent, C.T., Fedorov, V.D., Patsialou, A., Cherrington, B.D., Wakshlag, J.J., Mohanan, S., Zee, B.M., Zhang, X., Garcia, B.A., Condeelis, J., Brown, A.M, Coonrod, S.A. and Allis, C.D. (2013)  Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. PNAS.  110(29):11851-6. [PMCID: PMC3718105] 

Das, S., Sarrou, E., Podgrabinska, S., Cassella, M., Mungamuri, S.K., Feirt, N., Gordon, R., Nagi, C.S., Wang, Y., Entenberg, D., Condeelis, J., and Skobe, M. (2013) Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J. Exp. Med. 210(8):1509-28. [PMCID: PMC3727324] 

Bravo-Cordero, J.J., Magalhaes, M., Eddy, R., Hodgson, L., and Condeelis, J. (2013) Functions of cofilin in cell locomotion and invasion. Nature Rev. Mol. Cell Biol. 14(7):405-15. [PMCID: PMC3878614] 

Bravo-Cordero, J.J., Sharma, V., Roh-Johnson, M., Chen, X., Eddy, R., Condeelis, J. and Hodgson, L. (2013) Spatial regulation of RhoC activity defines protrusion formation in migrating cells. J. Cell Sci.  126(Pt 15):3356-69. [PMCID: PMC0370245] 

Sharma, V., Eddy, Entenberg, D., R., Kai, M., Gertler, F., and Condeelis, J. (2013) Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells. Current Biol. 23(21):2079-89.   [PMCID: PMC38882144] 

Patsialou, A., Bravo-Cordero, J.J., Wang, Y., Entenberg, D., Liu, H., Clarke, M.F., and Condeelis, J. (2013) Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. IntraVital. 2(2):e25294. [PMCID: PMC3908591] 

Ishihara D, Dovas A, Hernandez, L., Pozzuto M, Wyckoff, J., Segall, J., Condeelis, J., Bresnick AR and Cox, D. (2013) WASp Regulates Leukocyte-Dependent Breast Cancer Metastasis. Cell Rep. 4(3):429-436.   [PMCID: PMC3777703] 

Sharma, V.P., Entenberg, D., and Condeelis, J. (2013) High-resolution live-cell imaging and time-lapse microscopy of invadopodium dynamics and tracking analysis. Methods Mol. Biol.  1046:343-57. [PMCID: PMC3933219] 

Bravo-Cordero, J.J., Moshfegh, Y., Condeelis, J. and Hodgson, L. (2013) Live cell imaging of RhoGTPase biosensors in tumor cells. Methods in Mol. Biol. Chapter 22, Vol. 1046:359-70.  [PMCID: PMC3784404] 

Beaty, B., Sharma, V., Bravo-Cordero, J.J., Simpson, M.A., Eddy. R.J., Koleske, A.J. and Condeelis, J. (2013) β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Mol. Biol. Cell. 24(11):1661-75. [PMCID: PMC3667720] 

Entenberg, D., Kedrin, D., Wyckoff, J., Sahai, E., Condeelis, J., and Segall, J. (2013) Imaging Tumor Cell Movement In Vivo.  Current Protocols in Cell Biol. Chapter 19: Unit 19.7.  doi: 10.1002/0471143030.cb1907s58. [PMCID: PMC3722061] 

Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis, J., and Koleske AJ. (2013) Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene. 32(21):2622-30.  [PMCID: PMC3473103] 

Dovas, A., Patsialou, A., Harney, A.S., Condeelis, J., and Cox, D. (2013) Imaging interactions between macrophages and tumour cells that are involved in metastasis in vivo and in vitro. J. Microscopy. 251(3):261-9. doi: 10.1111/j.1365-2818.2012.03667.x. [PMCID: PMC4000025] 

Zervantonakis, I.K., Hughes-Alford, S.K., Charest, J.L., Condeelis, J., Gertler, F.B., and Kamm, R.D. (2012) Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. PNAS. 109(34):13515-20. [PMCID: PMC3427099] 

Subach, O., Entenberg, D., Condeelis, J. and Verkhusha, V. (2012) A FRET-Facilitated Photoswitching Using an Orange Fluorescent Protein with the Fast Photoconversion Kinetics. J. of the American Chem. Soc. 134(36):14789-99. [PMCID: PMC3444247] 

Smirnova, T., Zhou, Z.N., Flinn, R.J., Wyckoff, J., Boimel, P.J., Pozzuto, M., Coniglio, S.J., Backer, J.M., Bresnick, A.R., Condeelis, J.S., Hynes, N.E., and Segall, J.E. (2012). Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene 31, 706-715.   

Raja, W.K., Padgen, M.R., Williams, J.K., Gertler, F.B., Wyckoff, J.B., Condeelis, J.S., and Castracane, J. (2012). Development Path and Current Status of the NANIVID:  A New Device for Cancer Cell Studies. Journal of Micro/Nanolithography, MEMS, and MOEMS (JM3) 11, 0130131-0130139.   

Oktay, M.H., Gertler, F.B., Liu, Y.F., Rohan, T.E., Condeelis, J.S., and Jones, J.G. (2012). Correlated immunohistochemical and cytological assays for the prediction of hematogenous dissemination of breast cancer. J Histochem Cytochem 60, 168-173.   

Gligorijevic, B., Wyckoff, J., Yamaguchi, H., Wang, Y., Roussos, E.T., and Condeelis, J. (2012). N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci 125, 724-734.   

Bravo-Cordero, J.J., Hodgson, L., and Condeelis, J. (2012). Directed cell invasion and migration during metastasis. Curr Opin Cell Biol 24, 277-283. [PMCID PMC3320684]  

Bragado, P., Sosa, M.S., Keely, P., Condeelis, J., and Aguirre-Ghiso, J.A. (2012). Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res 195, 25-39.   

Boimel, P.J., Smirnova, T., Zhou, Z.N., Wyckoff, J., Park, H., Coniglio, S.J., Qian, B.Z., Stanley, E.R., Cox, D., Pollard, J.W., Muller, W.J., Condeelis, J., and Segall, J.E. (2012). Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Res 14, R23.   

Bravo-Cordero, J.J., Oser, M., Chen, X., Eddy, R., Hodgson, L., and Condeelis, J. (2011). A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol 21, 635-644. [PMCID PMC3081966]  

Dovas, A., Gligorijevic, B., Chen, X., Entenberg, D., Condeelis, J., and Cox, D. (2011). Visualization of actin polymerization in invasive structures of macrophages and carcinoma cells using photoconvertible beta-actin-Dendra2 fusion proteins. PLoS One 6, e16485. [PMCID PMC3038862]  

Entenberg, D., Wyckoff, J., Gligorijevic, B., Roussos, E.T., Verkhusha, V.V., Pollard, J.W., and Condeelis, J. (2011). Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc 6, 1500-1520.   

Gertler, F., and Condeelis, J. (2011). Metastasis: tumor cells becoming MENAcing. Trends Cell Biol 21, 81-90.   

Hernandez, L., Magalhaes, M.A., Coniglio, S.J., Condeelis, J.S., and Segall, J.E. (2011). Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res 13, R128. [PMCID PMC3326570]  

Mader, C.C., Oser, M., Magalhaes, M.A., Bravo-Cordero, J.J., Condeelis, J., Koleske, A.J., and Gil-Henn, H. (2011). An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res 71, 1730-1741. [PMCID PMC3057139]  

Magalhaes, M.A., Larson, D.R., Mader, C.C., Bravo-Cordero, J.J., Gil-Henn, H., Oser, M., Chen, X., Koleske, A.J., and Condeelis, J. (2011). Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. J Cell Biol 195, 903-920. [PMCID PMC3257566]  

Oser, M., Dovas, A., Cox, D., and Condeelis, J. (2011). Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. Eur J Cell Biol 90, 181-188. [PMCID PMC3017226]  

Roussos, E.T., Balsamo, M., Alford, S.K., Wyckoff, J.B., Gligorijevic, B., Wang, Y., Pozzuto, M., Stobezki, R., Goswami, S., Segall, J.E., Lauffenburger, D.A., Bresnick, A.R., Gertler, F.B., and Condeelis, J.S. (2011). Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci 124, 2120-2131. [PMCID PMC3113666]  

Roussos, E.T., Condeelis, J.S., and Patsialou, A. (2011). Chemotaxis in cancer. Nat Rev Cancer 11, 573-587.   

Roussos, E.T., Goswami, S., Balsamo, M., Wang, Y., Stobezki, R., Adler, E., Robinson, B.D., Jones, J.G., Gertler, F.B., Condeelis, J.S., and Oktay, M.H. (2011). Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis 28, 515-527.   

Sampaio, N.G., Yu, W., Cox, D., Wyckoff, J., Condeelis, J., Stanley, E.R., and Pixley, F.J. (2011). Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion. J Cell Sci 124, 2021-2031. [PMCID PMC3104034]  

Shapiro, I.M., Cheng, A.W., Flytzanis, N.C., Balsamo, M., Condeelis, J.S., Oktay, M.H., Burge, C.B., and Gertler, F.B. (2011). An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet 7, e1002218. [PMCID PMC3158048]  

Subach, O.M., Patterson, G.H., Ting, L.M., Wang, Y., Condeelis, J.S., and Verkhusha, V.V. (2011). A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nat Methods 8, 771-777. [PMCID PMC3164916]  

Tania, N., Prosk, E., Condeelis, J., and Edelstein-Keshet, L. (2011). A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells. Biophys J 100, 1883-1892. [PMCID PMC3077689]  

Wyckoff, J., Gligorijevic, B., Entenberg, D., Segall, J., and Condeelis, J. (2011). The in vivo invasion assay: preparation and handling of collection needles. Cold Spring Harb Protoc 2011, 1232-1234.   

Wyckoff, J., Gligorijevic, B., Entenberg, D., Segall, J., and Condeelis, J. (2011). High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harb Protoc 2011, 1167-1184.   

Condeelis, J., and Weissleder, R. (2010). In vivo imaging in cancer. Cold Spring Harb Perspect Biol 2, a003848.   

Isaac, B.M., Ishihara, D., Nusblat, L.M., Gevrey, J.C., Dovas, A., Condeelis, J., and Cox, D. (2010). N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis. Exp Cell Res 316, 3406-3416. [PMCID PMC2976787]  


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