Human Genomics in Development and Disease

Genetic Variation in Human Populations

We have characterized genetic variation in a number of human populations (Hispanics and Latinos, Jewish HapMap Project) to understand the origins and migrations of these populations.

Currently, we are exploring the role of natural selection in the formation of some of these populations. We are carrying the work forward to understand disease susceptibilities within these groups.  A key feature of this work is translating new findings into practice to promote personalized medicine.

Jewish Populations Revise HL PopulationsNEW


 

 
 

Recent Publications

Bryc K, et al. Genome-wide patterns of population structure andadmixture among Hispanic/Latino populations. Proc Natl Acad Sci USA. 107 Suppl2:8954-61, 2010.

Atzmon G,  et al. Abraham’schildren in the Genome Era: Major Jewish Diaspora populations comprise distinct genetic clusters with shared Middle Eastern ancestry. Am J Hum Genet. 86:850-9,2010.

Moorjani P, et al. The history of African gene flow into southern  Europeans, Levantines, and Jews. PLoS Genet.7(4):e1001373, 2011.

Velez C, Palamara PF, Guevara-Aguirre J, Hao L, Karafet T, Guevara-Aguirre M, Pearlman A, Oddoux C, Hammer M, Burns E, Pe'er I, Atzmon G, Ostrer H. The impact of Converso Jews on the genomes of modern Latin Americans. Hum Genet. 131:251-63, 2012.

Campbell CL, Palamara PF, Dubrovsky M, Botigué LR, Fellous M, Atzmon G, Oddoux C, Pearlman A, Hao L, Henn BM, Burns E, Bustamante CD, Comas D, Friedman E, Pe'er I, Ostrer H. North African Jewish and non-Jewish populations form distinctive, orthogonal clusters. Proc Natl Acad Sci USA 109:13865-70, 2012

Ostrer H, Skorecki K. The population genetics of the Jewish people. Hum Genet. 132:119-27, 2013. 

 

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