We have explored the roles of low and high-penetrance variants in risk of human cancers. We have also developed a molecular signature that is highly predictive of risk of metastasis.
Currently, we are identifying germline risk variants for other radiation toxicities and for cancer susceptibilities. We are extending the findings of the metastasis molecular signature to understand the health disparity of metastasis risk and to develop a useful clinical tool.
Legend: Plot of -log10 p values from allelic chi-square tests for association of each of the 512,497 single nucleotide polymorphisms (SNPs) with the development of post-radiotherapy erectile dysfunction in African American men treated with radiation therapy for prostate cancer.
Legend: Heatmap showing copy number amplifications and deletions for tumor samples in the metastasis gene signature. The tumor samples (X axis)
are arranged by subtype and furhter sorted by their metastatic potential score.
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