Human Genomics in Development and Disease

Chris Campbell

Research

Chris Campbell is a bioinformatician involved with a number of projects in the lab including population genetics and prostate cancer metastasis. He is currently investigating the genetics of Jewish Diaspora populations in North Africa, following up on a 2010 paper that presented the first in a series of studies of the Jewish people. Characterization of these populations revealed a distinct Jewish genetic component that could be traced back to the Jewish Diasporas, providing valuable information on the history of these populations.

Chris is also working to develop a computational tool that uses genetic information from prostate cancer biopsies to predict whether a tumor is likely to metastasize or remain indolent. This screen has the potential to significantly reduce the current over treatment of this disease, saving patients from the severe side effects associated with radical surgery.Previous to working in Dr. Ostrer's lab, he worked to identify the genetic basis of autoimmune disorders, such as diabetes, and developed robotics platforms to perform high-throughput drug screens and genotyping.

chris.campbell@einstein.yu.edu 

 

Publications

[1] Sarah L Kerns, Harry Ostrer, Richard Stock, William Li, Julian Moore, Alexander Pearlman, Christopher Campbell, Yongzhao Shao, Nelson Stone, Lynda Kusnetz, and Barry S Rosenstein. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys, 78(5):1292–1300, Dec 2010.

[2] Vincent Butty, Christopher Campbell, Diane Mathis, Christophe Benoist, and DPT-1 Study Group. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the Diabetes Prevention Trial-type 1 (DPT-1). Diabetes, 57(9):2348–2359, Sep 2008.

[3] Junko Nishio, Jason L Gaglia, Stuart E Turvey, Christopher Campbell, Christophe Benoist, and Diane Mathis. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science, 311(5768):1775–1778, Mar 2006.

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