Professor, Department of Medicine (Cardiology)
Professor, Department of Radiology (Nuclear Medicine)
Chief, Division of Cardiology, Department of Medicine at Beth Israel Medical Center
Selected Peer Reviewed Articles:
Ahumada GG, Bergmann SR, Carlson E, Corr PB, Sobel BE: Augmentation of cyclic AMP content induced by lysophosphatidyl choline in rabbit hearts. Cardiovasc. Res. 1979; 13:377‑382.
Bergmann SR, Clark RE, Sobel BE: An improved isolated heart preparation for external assessment of myocardial metabolism. Am. J. Physiol.: Heart Circ. Physiol. 1979; 236:H644‑H65l.
Bergmann SR, Hack S, Tewson TJ, Welch MJ, Sobel BE: The dependence of accumulation of 13NH3 by myocardium on metabolic factors and its implications for quantitative assessment of perfusion. Circulation 1980;61:34‑43.
Hack S, Eichling JO, Bergmann SR, Sobel BE: External quantification of myocardial perfusion by exponential infusion of positron emitting radionuclides. J. Clin. Invest. 1980; 66:9l8‑927.
Lange LG, Bergmann SR, Sobel BE: Identification of fatty acid ethyl esters as products of rabbit myocardial ethanol metabolism. J. Biol. Chem. 1981; 256:12968‑12973.
Lerch RA, Ambos HD, Bergmann SR, Welch MJ, Ter‑Pogossian MM, Sobel BE: Localization of viable but ischemic myocardium by positron emission tomography (PET) with 11C‑palmitate. Circulation 1981; 64:689‑699.
Bergmann SR, Lerch RA, Carlson EM, Saffitz JE, Sobel BE: Detection of cardiac transplant rejection with radiolabeled lymphocytes. Circulation 1982;65:591‑59.
Bergmann SR, Lerch RA, Fox KAA, Ludbrook PA, Welch MJ, Ter‑Pogossian MM, Sobel BE: Temporal dependence of beneficial effects of coronary thrombolysis characterized by positron tomography. Am. J. Med. 1982;73:573‑581.
Lerch RA, Bergmann SR, Ambos HD, Welch MJ, Ter‑Pogossian MM, Sobel BE: Effect of flow‑independent reduction of metabolism on regional myocardial clearance of 11C‑palmitate. Circulation 1982; 65:731‑738.
Bergmann SR, Fox KAA, Ter‑Pogossian MM, Sobel BE, Collen D: Clot‑selective coronary thrombolysis with tissue‑type plasminogen activator. Science 1983; 220:1181‑1183.
Fox KAA, Nomura H, Sobel BE, Bergmann SR: Consistent substrate utilization despite reduced flow in hearts with maintained work. Am. J. Physiol:Heart Circ. Physiol. 1983;244:H799‑H806.
Bergmann SR, Fox KAA, Rand AL, McElvany KD, Welch MJ, Markham J, Sobel BE: Quantification of regional myocardial blood flow in vivo with H2150. Circulation 1984;70:724‑733.
Van de Werf F, Bergmann SR, Fox KAA, De Geest H, Hoyng CF, Sobel BE, Collen D: Coronary thrombolysis with intravenously administered human tissue‑type plasminogen activator produced by recombinant DNA technology. Circulation 1984;69:605‑610.
Van de Werf F, Ludbrook PA, Bergmann SR, Tiefenbrunn AJ, Fox KAA, De Geest H, Verstraete M, Collen D, Sobel BE: Coronary thrombolysis with tissue‑type plasminogen activator in patients with evolving myocardial infarction. N. Engl. J. Med. 1984;310: 609‑6l3.
Fox KAA, Abendschein D, Ambos HD, Sobel BE, Bergmann SR: Efflux of metabolized and nonmetabolized fatty acid from canine myocardium. Implications for quantifying myocardial metabolism tomographically. Circ. Res. 1985;57:232‑243.
Fields LE, Daugherty A, Bergmann SR: Effect of fatty acid on performance and lipid content of hearts from diabetic rabbits. Am. J. Physiol.: Heart Circ. Physiol. 1986; 250:H1079‑H1085.
Brown MA, Marshall DR, Sobel BE, Bergmann SR: Delineation of myocardial oxygen utilization with carbon‑11 labeled acetate. Circulation 1987;76:687‑696.
Eisen HJ, Eisenberg SB, Saffitz JE, Bolman RM, Sobel BE, Bergmann SR: Non‑invasive detection of rejection of transplanted hearts with indium‑111 labeled lymphocytes. Circulation 1987;75:868‑876.
Myears DW, Sobel BE, Bergmann SR: Substrate use in ischemic and reperfused canine myocardium: quantitative onsiderations. Am. J. Physiol.:Heart Circ. Physiol. 1987;253:H107‑H114.
Herrero P, Markham J, Myears DW, Weinheimer CJ, Bergmann SR: Measurement of myocardial blood flow with positron emission tomography: correction for count spillover and partial volume effects. Mathl. Comput. Modelling 1988;11:807‑812.
Myears DW, Nohara R, Abendschein DR, Saffitz JE, Sobel BE, Bergmann SR: Compromise of beneficial effects of reperfusion on myocardium supplied by vessels with critical residual stenosis. J. Am. Coll. Cardiol. 1988;11:1078‑1086.
Walsh MN, Bergmann SR, Steele RL, Kenzora JL, Ter‑Pogossian MM, Sobel BE, Geltman EM: Delineation of impaired regional myocardial perfusion by positron emission tomography with H215O. Circulation 1988; 78:612‑620.
Bergmann SR, Herrero P, Markham J, Weinheimer CJ, Walsh MN: Non-invasive quantitation of myocardial blood flow in human subjects with oxygen‑15‑labeled water and positron emission tomography. J. Am. Coll. Cardiol. 1989; 14:639‑652.
Brown MA, Myears DW, and Bergmann SR: Validity of estimates of myocardial oxidative metabolism with carbon‑11 acetate and positron emission tomography despite altered patterns of substrate utilization. J. Nucl. Med. 1989; 30:187‑193.
Henes GC, Bergmann SR, Walsh MN, Sobel BE, Geltman EM: Assessment of myocardial oxidative metabolic reserve with positron emission tomography and carbon‑11 acetate. J. Nucl. Med. 1989; 30:1489‑1499.
Koller PT, Bergmann SR: Reduction of lipid peroxidation in reperfused isolated rabbit hearts by diltiazem. Circ. Res. 1989; 65:838‑846.
Nohara R, Abendschein DR, Bergmann SR: Transmural gradients of coronary flow reserve with physiologically and morphometrically defined stenoses in dogs. Am. Heart J. 1989; 118:1167‑75.
Shelton ME, Dence CS, Hwang DR, Welch MJ, Bergmann SR: Myocardial kinetics of fluorine‑18 misonidazole: a marker of hypoxic myocardium. J. Nucl. Med. 1989; 30:351‑358.
Walsh MN, Geltman EM, Steele RL, Kenzora JL, Ludbrook PA, Sobel BE, Bergmann SR: Augmented myocardial perfusion reserve after coronary angioplasty quantified by positron emission tomography with H215O. J. Am. Coll. Cardiol. 1990; 15:119‑127.
Gropler RJ, Siegel BA, Lee KJ, Moerlein SM, Perry DJ, Bergmann SR, Geltman EM: Nonuniformity in myocardial accumulation of fluorine‑18‑fluorodeoxy-glucose in normal fasted humans. J. Nucl. Med. 1990; 31:1749‑1756.
Geltman EM, Henes CG, Senneff MJ, Sobel BE, Bergmann SR: Increased myocardial perfusion at rest and diminished perfusion reserve in patients with angina and angiographically normal coronary arteries. J. Am. Coll. Cardiol. 1990; 16:586‑595.
Miller TR, Wallis JW, Geltman EM, Bergmann SR: Three‑dimensional functional images of myocardial oxygen consumption from positron tomography. J. Nucl. Med. 1990; 31:2064‑2068.
Senneff MJ, Geltman EM, Bergmann SR: Noninvasive delineation of the effects of moderate aging on myocardial perfusion. J. Nucl. Med. 1991; 32:2037‑2042.
Ord JM, Hasapes J, Daugherty A, Thorpe SR, Bergmann SR, Sobel BE: Imaging of thrombi with tissue‑type plasminogen activator rendered enzymatically inactive and conjugated to a residualizing label. Circulation 1992; 85:288‑297.
Gropler RJ, Siegel BA, Sampathkumaran K, Perez JE, Sobel BE, Bergmann SR, Geltman EM: Dependence of recovery of contractile function on maintenance of oxidative metabolism after myocardial infarction. J. Am. Coll. Cardiol. 1992; 19:989‑997.
Herrero P, Markham J, Shelton ME, and Bergmann SR: Implementation and evaluation of a two‑compartment model for quantification of myocardial perfusion with rubidium‑82 and positron emission tomography. Circ. Res. 1992; 70:496‑507.
Gropler RJ, Geltman EM, Sampathkumaran K, Perez JE, Moerlein SM, Sobel BE, Bergmann SR, Siegel BA: Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism. J. Am. Coll. Cardiol. 1992; 20:569‑577.
Herrero P, Markham J, Weinheimer CJ, Anderson CJ, Welch MJ, Green MA, Bergmann SR: Quantification of regional myocardial perfusion with generator‑produced 62Cu‑PTSM and positron emission tomography. Circulation 1993;87:173-183.
Senneff MJ, Hartman JJ, Sobel BE, Geltman EM, Bergmann SR: Persistence of coronary vasodilator responsivity after cardiac transplantation. Am. J. Cardiol. 1993; 71:333-338.
Kelly DP, Mendelsohn NJ, Sobel BE, Bergmann SR: Detection and assessment by positron emission tomography of a genetically determined defect in myocardial fatty acid utilization (long‑chain acyl‑CoA dehydrogenase deficiency). Am. J. Cardiol. 1993; 71:738-744.
Vanoverschelde JL, Janier MF, Bergmann SR: The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated perfused rabbit hearts. Circ. Res. 1994; 74:817-828.
Bergmann SR, Weinheimer CJ, Brown MA, Perez JE: Enhancement of regional myocardial efficiency and persistence of perfusion, oxidative and functional reserve with paired pacing of stunned myocardium. Circulation 1994; 89:2290-2296.
Vanoverschelde JL, Janier MF, Bakke ME, Marshall DR, Bergmann SR: Rate of glycolysis during ischemia determines the extent of ischemic injury and functional recovery following reperfusion. Am. J. Physiol.: Heart Circ. Physiol. 1994; 267:H1785 1794.
Janier MF, Vanoverschelde JL, Bergmann SR: Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart. Am. J. Physiol.: Heart Circ. Physiol. 1994; 267:H1353-1360.
Bergmann SR, Weinheimer CJ, Markham J, Herrero P: Quantitation of myocardial fatty acid metabolism using PET. J Nucl Med 1996; 37:1723-1730.
Herrero P, Hartman JJ, Green MA, Anderson CJ, Welch MJ, Markham J, Bergmann SR: Regional myocardial perfusion assessed with generator-produced Copper-62-PTSM and PET. J Nucl Med 1996; 37:1294-1300.
Rubin PJ, Hartman JJ, Hasapes J, Bakke JE, Bergmann SR: Detection of cardiac transplant rejection with 111In-labeled lymphocytes and gamma scintigraphy. Circulation, 94 (Suppl II):II-298-303, 1996.
Akinboboye O, Idris O, Cannon P, and Bergmann S: Usefulness of positron emission tomography in defining myocardial viability in patients referred for cardiac transplantation. Am. J. Cardiol. 1999; 83:1271-1274.
Salaris S, Ramasamy R, and Bergmann SR: Fructose-2, 6-Bisphosphate, a potent stimulator of phosphofructokinase, is increased by high exogenous glucose perfusion. Coronary Art. Dis. 2000; 11:279-286.
Ababneh AA, Sciacca RR, Kim B, Bergmann, SR: Normal limits for left ventricular ejection fraction and volumes estimated with gated myocardial perfusion imaging in subjects with normal exercise tests: Influence of tracer, gender and acquisition camera. J. Nucl. Cardiol. 2000; 7:661-668.
Lin JW, Laine AF, Akinboboye O, Bergmann SR: Use of wavelet transforms in the analysis of time-activity data from cardiac PET. J. Nucl. Med. 2001; 42:194-200. Lin JW, Sciacca R, Chou RL, Laine A, Bergmann SR: Quantification of myocardial perfusion in human subjects using rubidium-82 and wavelet-based noise reduction. J. Nucl. Med. 2001; 42:201-208.
Rohatgi R, Epstein, S, Henriquez J, Ababneh AA, Hickey KT, Pinsky D, Akinboboye O, Bergmann, SR: Utility of positron emission tomography in predicting cardiac events and survival in patients with coronary artery disease and severe left ventricular dysfunction. Am. J. Cardiol. 2001; 87:1096-1099.
Ramasamy R, Hwang YC, Whang J, Bergmann SR: Protection of ischemic hearts by high glucose is mediated, in part, by GLUT-4. Am. J. Physiol. Heart Circ. Physiol. 2001; 281:H290-H297.
Ramasamy R, Schaefer S, Whang J, Bergmann SR, Payne J: Protection of ischemic myocardium in diabetics by inhibition of the electroneutral Na++-K+-2Cl- co-transporter. Am. J. Physiol. Heart Circ. Physiol. 2001; 281:H515-522.
Ramasamy R, Hwang Y, Bakr S, Bergmann SR: Protection of ischemic hearts perfused with an anion exchange inhibitor, DIDS, is associated with beneficial changes in substrate metabolism. Cardiovasc. Res. 2001; 51:275-282.
Akinboboye, OO, Idris O, Onwuanyi A, Berekashvii K, Bergmann SR: Incidence of major cardiovascular events in black patients with normal myocardial stress perfusion studies. J. Nucl. Cardiol. 2001; 8:541-547.
Biviano AB, Bergmann SR, Tenenbaum J, Sullivan J, Hurley E, Giglio J, Rabbani L. Design of a comprehensive chest pain initiative in an academic urban hospital. Critical Pathways in Cardiology 2003; 2:113-117.
Hickey KT, Sciacca RR, Bokhari S, Rodriguez O, Chou R-L, Faber TL, Cooke CD, Garcia EV, Nichols K, Bergmann SR. Assessment of cardiac wall motion and ejection fraction with gated PET using N-13 ammonia. Clin. Nucl. Med. 2004; 29:243-248.
Xydas S, Rosen RS, Pinney S, Hickey KT, Wasserman H, Mancini DM, Naka Y, Oz MC, Bergmann SR, Maybaum S. Reduced myocardial blood flow during left ventricular assist device support: A possible cause of premature bypass graft closure. J. Heart and Lung Transpl. 2005 Nov; 24(11):1976-1979.
Hickey KT, Sciacca RR, Chou RL, Rodriguez O, Bokhari S, Bergmann SR. An improved model for the measurement of myocardial perfusion in human beings using N-13
ammonia. J Nucl Cardiol 2005; 12:311-317.
Obunai K, Misra D, VanTosh A, Bergmann SR: Metabolic evidence of myocardial stunning in takotsubo cardiomyopathy: A positron emission tomography study.
J. Nucl. Cardiol 2005; 12:742-4.
Weinsaft JW, Hickey KT, Bokhari S, Shahzad A, Bedding A, Costigan TM, Warner MR, Emmick JT, Bergmann SR. Effects of tadalafil on myocardial blood flow in patients with coronary artery disease. Coronary Artery Disease. 2006; 17:493-499.
Boyle AJ, Whitbourn R, Schlicht S, Krum H, Kocher A, Nandurkar H, Bergmann SR, Daniell M, O'Day J, Skerrett D, Haylock D, Gilbert RE, Itescu S. Intra-coronary high dose CD34+ stem cells in patients with chronic ischemic heart disease: a 12-month follow-up. Int J Cardiol. 2006; 109:21-7.
Somekh NN, Rachko M, Husk G, Friedmann P, Bergmann SR. Differences in diagnostic evaluation and clinical outcomes in the care of patients with chest pain based on admitting service: the benefits of a dedicated chest pain unit. J Nucl Cardiol. 2008; 15:186-192.
Bokhari S, Shahzad A, Bergmann SR. Superiority of Exercise Myocardial Perfusion Imaging Compared with the Exercise ECG in the Diagnosis of Coronary Artery Disease. Coronary Artery Disease. 2008; 19: 399-404
Kawut SM, Al-Naamani, N, Agerstaad, C, Rosenzweig, EB, Rowan, C, Barst, RJ, Bergmann, SR, Horn, EM. Determinants of right ventricular ejection fraction in patients with pulmonary arterial hypertension. Chest. 2009; 135: 752-759.
Inaba Y, Bergmann SR. Prognostic value of myocardial metabolic imaging with BMIPP in the spectrum of coronary artery disease: a systematic review. J Nucl Cardiol. 2010 17:61-70, 2010
Inaba Y, Bergmann SR. Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: a meta-analysis. J Nucl Cardiol, 2010. In press.
Inaba Y, Chen JA, Bergmann SR. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 2010. In press.
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.
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