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Faculty Profile

Felipe Diaz-Griffero, Ph.D.

Dr. Felipe Diaz-Griffero

Associate Professor, Department of Microbiology & Immunology

Elsie Wachtel Faculty Scholar


Professional Interests

Our laboratory is interested on understanding the mechanism used by restriction factors (endogenously expressed proteins) to restrict HIV-1 replication. The restriction factors TRIM5alpha and TRIMCyp are monkey proteins that potently block HIV-1 during uncoating—the initial step of HIV-1 replication. Our investigations have demonstrated that TRIM5 proteins block HIV-1 replication by potently inhibiting reverse transcription--essential early step in HIV-1 replication that converts the viral RNA in viral DNA and allowing productive infection. We are using these restriction factors to carefully define the uncoating mechanism of HIV-1, which will give rise to new ways to inhibit HIV-1 replication and treat HIV-1/AIDS. We have established that these restrictions factors accelerate uncoating making HIV-1 replication abortive. Our investigations will attempt to mechanistically define the timing of uncoating and reverse transcription during replication. Interestingly but not surprisingly these restriction factors block HIV-1 replication extremely potently and better than any drug known to date. We like to say not surprisingly since these restriction factors were design by nature block HIV-1 replication, and nature knows best.

The main focus of the lab is to define HIV-1 uncoating by using biological and biochemical assays. One of the most important questions in the HIV-1 field is to understand the relationship between uncoating and reverse transcription. We currently have in vivo and vitro assays to follow the uncoating and reverse transcription of HIV-1. These assays had allowed us to better understand how reverse transcription is block during the accelerated uncoating triggered by TRIM5alpha and TRIMCyp. We are also studying the structural biology of these restriction factors attempting to identify the TRIM5alpha domains required to block HIV-1 replication. We have also created mice strains that do not contain TRIM5alpha to understand the in vivo role of TRIM5alpha.

To understand uncoating in a broader manner, we are also studying the molecule transportin-3 (TNPO3) known to be required for HIV-1 replication during the initial steps of HIV-1 replication. We are identifying which proteins of the HIV-1 virus is required to interact with TNPO3, which is a nuclear transporter. We think that this transporter promotes HIV-1 uncoating in the nuclear pore and assist the transport of HIV-1 to the nucleus of the cells allowing productive infection. We have also created mice strains that do not express transporting to better understand the role of TNPO3 in HIV-1 replication using and in vivo model.

Finally, we are studying HIV-1 infected patients known as elite controllers—HIV-1 infected patients that never develop AIDS. We strongly believe that these individuals have novel ways to restrict HIV-1 replication, which will help us to develop new therapies against HIV-1/AIDS. Among this novel ways to restrict HIV-1 replication, we hypothesize the existence of new restriction factors in T cells that block HIV-1 replication. For this purpose, we are currently investigating HIV-1 replication blocks in T cells. We have several T cell lines that block HIV-1 replication at early stages suggesting the existence of a block similar to the one imposed by TRIM5alpha to HIV-1 replication.

Overall, our laboratory is interested in defining the uncoating process of HIV-1 replication by using restriction factors such as TRIM5alpha, TRIMCyp and T cell restrictors, or proteins that assist uncoating such us transportin-3 (TNPO3).  We are certain that these investigations will lead to novel and unforeseeable ways to treat HIV-1/AIDS.


Selected Publications


1: Schulte B, Buffone C, Opp S, Di Nunzio F, Augusto De Souza Aranha Vieira D,

Brandariz-Nuñez A, Diaz-Griffero F. Restriction of HIV-1 Requires the N-terminal

Region of MxB/Mx2 as a Capsid-Binding Motif but not as a Nuclear Localization

Signal. J Virol. 2015 Jun 10. pii: JVI.00753-15. [Epub ahead of print] PubMed

PMID: 26063425.



2: Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA,

Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH. HIV-1 capsids bind and exploit

the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun. 2015

Mar 30;6:6660. doi: 10.1038/ncomms7660. PubMed PMID: 25818806; PubMed Central

PMCID: PMC4380233.



3: Lelek M, Casartelli N, Pellin D, Rizzi E, Souque P, Severgnini M, Di Serio C,

Fricke T, Diaz-Griffero F, Zimmer C, Charneau P, Di Nunzio F. Chromatin

organization at the nuclear pore favours HIV replication. Nat Commun. 2015 Mar

6;6:6483. doi: 10.1038/ncomms7483. PubMed PMID: 25744187; PubMed Central PMCID:




4: Buffone C, Schulte B, Opp S, Diaz-Griffero F. Contribution of MxB

oligomerization to HIV-1 capsid binding and restriction. J Virol. 2015

Mar;89(6):3285-94. doi: 10.1128/JVI.03730-14. Epub 2015 Jan 7. PubMed PMID:

25568212; PubMed Central PMCID: PMC4337540.



5: Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler

B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M.

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. Proc Natl Acad

Sci U S A. 2014 Dec 30;111(52):18625-30. doi: 10.1073/pnas.1419945112. Epub 2014

Dec 17. PubMed PMID: 25518861; PubMed Central PMCID: PMC4284599.



6: Fricke T, Buffone C, Opp S, Valle-Casuso J, Diaz-Griffero F. BI-2 destabilizes

HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid.

Retrovirology. 2014 Dec 11;11:120. doi: 10.1186/s12977-014-0120-x. PubMed PMID:

25496772; PubMed Central PMCID: PMC4271331.



7: Lukic Z, Dharan A, Fricke T, Diaz-Griffero F, Campbell EM. HIV-1 uncoating is

facilitated by dynein and kinesin 1. J Virol. 2014 Dec;88(23):13613-25. doi:

10.1128/JVI.02219-14. Epub 2014 Sep 17. PubMed PMID: 25231297; PubMed Central

PMCID: PMC4248982.



8: Hollenbaugh JA, Tao S, Lenzi GM, Ryu S, Kim DH, Diaz-Griffero F, Schinazi RF,

Kim B. dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived

macrophages. Retrovirology. 2014 Aug 27;11:63. doi: 10.1186/s12977-014-0063-2.

PubMed PMID: 25158827; PubMed Central PMCID: PMC4161909.



9: Fricke T, White TE, Schulte B, de Souza Aranha Vieira DA, Dharan A, Campbell

EM, Brandariz-Nuñez A, Diaz-Griffero F. MxB binds to the HIV-1 core and prevents

the uncoating process of HIV-1. Retrovirology. 2014 Aug 14;11:68. doi:

10.1186/PREACCEPT-6453674081373986. PubMed PMID: 25123063; PubMed Central PMCID:




10: Fricke T, White TE, Schulte B, de Souza Aranha Vieira DA, Dharan A, Campbell

EM, Brandariz-Nuñez A, Diaz-Griffero F. MxB binds to the HIV-1 core and prevents

the uncoating process of HIV-1. Retrovirology. 2014 Aug 14;11:68. doi:

10.1186/s12977-014-0068-x. PubMed PMID: 25927471.



11: Sastri J, Johnsen L, Smolin N, Imam S, Mukherjee S, Lukic Z, Brandariz-Nuñez

A, Robia SL, Diaz-Griffero F, Wiethoff C, Campbell EM. Restriction of HIV-1 by

rhesus TRIM5α is governed by alpha helices in the Linker2 region. J Virol. 2014

Aug;88(16):8911-23. doi: 10.1128/JVI.01134-14. Epub 2014 May 28. PubMed PMID:

24872590; PubMed Central PMCID: PMC4136267.



12: Ryoo J, Choi J, Oh C, Kim S, Seo M, Kim SY, Seo D, Kim J, White TE,

Brandariz-Nuñez A, Diaz-Griffero F, Yun CH, Hollenbaugh JA, Kim B, Baek D, Ahn K.

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med.

2014 Aug;20(8):936-41. doi: 10.1038/nm.3626. Epub 2014 Jul 20. PubMed PMID:

25038827; PubMed Central PMCID: PMC4318684.



13: White TE, Brandariz-Nuñez A, Valle-Casuso JC, Knowlton C, Kim B, Sawyer SL,

Diaz-Griffero F. Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.

Virology. 2014 Jul;460-461:34-44. doi: 10.1016/j.virol.2014.04.023. Epub 2014 May

29. PubMed PMID: 25010268; PubMed Central PMCID: PMC4101048.



14: St Gelais C, de Silva S, Hach JC, White TE, Diaz-Griffero F, Yount JS, Wu L.

Identification of cellular proteins interacting with the retroviral restriction

factor SAMHD1. J Virol. 2014 May;88(10):5834-44. doi: 10.1128/JVI.00155-14. Epub

2014 Mar 12. Erratum in: J Virol. 2014 Jul;88(13):7689. PubMed PMID: 24623419;

PubMed Central PMCID: PMC4019113.



15: Yang Y, Brandariz-Nuñez A, Fricke T, Ivanov DN, Sarnak Z, Diaz-Griffero F.

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not

sufficient for HIV-1 restriction. Virology. 2014 Jan 5;448:217-28. doi:

10.1016/j.virol.2013.10.012. Epub 2013 Oct 31. PubMed PMID: 24314652; PubMed

Central PMCID: PMC3900861.



16: Yang Y, Luban J, Diaz-Griffero F. The fate of HIV-1 capsid: a biochemical

assay for HIV-1 uncoating. Methods Mol Biol. 2014;1087:29-36. doi:

10.1007/978-1-62703-670-2_3. PubMed PMID: 24158811; PubMed Central PMCID:




17: Brojatsch J, Lima H, Kar AK, Jacobson LS, Muehlbauer SM, Chandran K,

Diaz-Griffero F. A proteolytic cascade controls lysosome rupture and necrotic

cell death mediated by lysosome-destabilizing adjuvants. PLoS One. 2014 Jun

3;9(6):e95032. doi: 10.1371/journal.pone.0095032. eCollection 2014. PubMed PMID:

24893007; PubMed Central PMCID: PMC4043491.



18: Biris N, Tomashevski A, Bhattacharya A, Diaz-Griffero F, Ivanov DN. Rhesus

monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid

monomers on the surface of the HIV-1 mature viral core. J Mol Biol. 2013 Dec

13;425(24):5032-44. doi: 10.1016/j.jmb.2013.07.025. Epub 2013 Jul 23. PubMed

PMID: 23886867; PubMed Central PMCID: PMC4116666.



19: Kim ET, White TE, Brandariz-Núñez A, Diaz-Griffero F, Weitzman MD. SAMHD1

restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J

Virol. 2013 Dec;87(23):12949-56. doi: 10.1128/JVI.02291-13. Epub 2013 Sep 25.

PubMed PMID: 24067963; PubMed Central PMCID: PMC3838123.



20: Brandariz-Nuñez A, Valle-Casuso JC, White TE, Nguyen L, Bhattacharya A, Wang

Z, Demeler B, Amie S, Knowlton C, Kim B, Ivanov DN, Diaz-Griffero F. Contribution

of oligomerization to the anti-HIV-1 properties of SAMHD1. Retrovirology. 2013

Nov 12;10:131. doi: 10.1186/1742-4690-10-131. PubMed PMID: 24219908; PubMed

Central PMCID: PMC3882887.



21: Fricke T, Brandariz-Nuñez A, Wang X, Smith AB 3rd, Diaz-Griffero F. Human

cytosolic extracts stabilize the HIV-1 core. J Virol. 2013 Oct;87(19):10587-97.

doi: 10.1128/JVI.01705-13. Epub 2013 Jul 24. PubMed PMID: 23885082; PubMed

Central PMCID: PMC3807412.



22: Lima H Jr, Jacobson LS, Goldberg MF, Chandran K, Diaz-Griffero F, Lisanti MP,

Brojatsch J. Role of lysosome rupture in controlling Nlrp3 signaling and necrotic

cell death. Cell Cycle. 2013 Jun 15;12(12):1868-78. doi: 10.4161/cc.24903. Epub

2013 May 20. PubMed PMID: 23708522; PubMed Central PMCID: PMC3735701.



23: Di Nunzio F, Fricke T, Miccio A, Valle-Casuso JC, Perez P, Souque P, Rizzi E,

Severgnini M, Mavilio F, Charneau P, Diaz-Griffero F. Nup153 and Nup98 bind the

HIV-1 core and contribute to the early steps of HIV-1 replication. Virology. 2013

May 25;440(1):8-18. doi: 10.1016/j.virol.2013.02.008. Epub 2013 Mar 21. PubMed

PMID: 23523133; PubMed Central PMCID: PMC3860269.



24: Pham QT, Veillette M, Brandariz-Nuñez A, Pawlica P, Thibert-Lefebvre C,

Chandonnet N, Diaz-Griffero F, Berthoux L. A novel aminoacid determinant of HIV-1

restriction in the TRIM5α variable 1 region isolated in a random mutagenic

screen. Virus Res. 2013 May;173(2):306-14. doi: 10.1016/j.virusres.2013.01.013.

Epub 2013 Jan 25. PubMed PMID: 23357295; PubMed Central PMCID: PMC4317569.



25: Fricke T, Valle-Casuso JC, White TE, Brandariz-Nuñez A, Bosche WJ, Reszka N,

Gorelick R, Diaz-Griffero F. The ability of TNPO3-depleted cells to inhibit HIV-1

infection requires CPSF6. Retrovirology. 2013 Apr 26;10:46. doi:

10.1186/1742-4690-10-46. PubMed PMID: 23622145; PubMed Central PMCID: PMC3695788.



26: White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen LA, Kim B,

Tuzova M, Diaz-Griffero F. The retroviral restriction ability of SAMHD1, but not

its deoxynucleotide triphosphohydrolase activity, is regulated by

phosphorylation. Cell Host Microbe. 2013 Apr 17;13(4):441-51. doi:

10.1016/j.chom.2013.03.005. PubMed PMID: 23601106; PubMed Central PMCID:




27: Jacobson LS, Lima H Jr, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS,

Joyce JA, Gapp BV, Blomen VA, Chandran K, Brummelkamp TR, Diaz-Griffero F,

Brojatsch J. Cathepsin-mediated necrosis controls the adaptive immune response by

Th2 (T helper type 2)-associated adjuvants. J Biol Chem. 2013 Mar

15;288(11):7481-91. doi: 10.1074/jbc.M112.400655. Epub 2013 Jan 7. PubMed PMID:

23297415; PubMed Central PMCID: PMC3597789.



28: White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen L, Kim B,

Brojatsch J, Diaz-Griffero F. Contribution of SAM and HD domains to retroviral

restriction mediated by human SAMHD1. Virology. 2013 Feb 5;436(1):81-90. doi:

10.1016/j.virol.2012.10.029. Epub 2012 Nov 13. PubMed PMID: 23158101; PubMed

Central PMCID: PMC3767443.



29: Brandariz-Nuñez A, Roa A, Valle-Casuso JC, Biris N, Ivanov D, Diaz-Griffero

F. Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral

properties of TRIM5α. Virology. 2013 Jan 20;435(2):463-71. doi:

10.1016/j.virol.2012.09.042. Epub 2012 Oct 16. PubMed PMID: 23084420; PubMed

Central PMCID: PMC3534947.



30: Yang Y, Fricke T, Diaz-Griffero F. Inhibition of reverse transcriptase

activity increases stability of the HIV-1 core. J Virol. 2013 Jan;87(1):683-7.

doi: 10.1128/JVI.01228-12. Epub 2012 Oct 17. PubMed PMID: 23077298; PubMed

Central PMCID: PMC3536417.



31: Fassler M, Weissberg I, Levy N, Diaz-Griffero F, Monsonego A, Friedman A,

Taube R. Preferential lentiviral targeting of astrocytes in the central nervous

system. PLoS One. 2013 Oct 2;8(10):e76092. doi: 10.1371/journal.pone.0076092.

eCollection 2013. PubMed PMID: 24098426; PubMed Central PMCID: PMC3788778.



32: Welbourn S, Miyagi E, White TE, Diaz-Griffero F, Strebel K. Identification

and characterization of naturally occurring splice variants of SAMHD1.

Retrovirology. 2012 Oct 23;9:86. doi: 10.1186/1742-4690-9-86. PubMed PMID:

23092512; PubMed Central PMCID: PMC3503569.



33: Biris N, Yang Y, Taylor AB, Tomashevski A, Guo M, Hart PJ, Diaz-Griffero F, Ivanov DN.

Structureof the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13278-83. doi:  10.1073/pnas.1203536109.

Epub 2012 Jul 30. PubMed PMID: 22847415; PubMed Central PMCID: PMC3421187.



34: Brandariz-Nuñez A, Valle-Casuso JC, White TE, Laguette N, Benkirane M,

Brojatsch J, Diaz-Griffero F. Role of SAMHD1 nuclear localization in restriction

of HIV-1 and SIVmac. Retrovirology. 2012 Jun 12;9:49. doi:

10.1186/1742-4690-9-49. PubMed PMID: 22691373; PubMed Central PMCID: PMC3410799.



35: Valle-Casuso JC, Di Nunzio F, Yang Y, Reszka N, Lienlaf M, Arhel N, Perez P,

Brass AL, Diaz-Griffero F. TNPO3 is required for HIV-1 replication after nuclear

import but prior to integration and binds the HIV-1 core. J Virol. 2012

May;86(10):5931-6. doi: 10.1128/JVI.00451-12. Epub 2012 Mar 7. PubMed PMID:

22398280; PubMed Central PMCID: PMC3347269.



36: Roa A, Hayashi F, Yang Y, Lienlaf M, Zhou J, Shi J, Watanabe S, Kigawa T,

Yokoyama S, Aiken C, Diaz-Griffero F. RING domain mutations uncouple TRIM5α

restriction of HIV-1 from inhibition of reverse transcription and acceleration of

uncoating. J Virol. 2012 Feb;86(3):1717-27. doi: 10.1128/JVI.05811-11. Epub 2011

Nov 23. PubMed PMID: 22114335; PubMed Central PMCID: PMC3264337.



37: Diaz-Griffero F. The Role of TNPO3 in HIV-1 Replication. Mol Biol Int.

2012;2012:868597. doi: 10.1155/2012/868597. Epub 2012 Jul 19. PubMed PMID:

22888429; PubMed Central PMCID: PMC3409535.



38: Di Nunzio F, Danckaert A, Fricke T, Perez P, Fernandez J, Perret E, Roux P,

Shorte S, Charneau P, Diaz-Griffero F, Arhel NJ. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS One.

2012;7(9):e46037. doi: 10.1371/journal.pone.0046037. Epub 2012 Sep 25. Erratum

in: PLoS One. 2013;8(12).doi:10.1371/annotation/34f46796-5d53-4a23-b3df-b599b0369eb9. PubMed PMID: 23049930; PubMed Central PMCID: PMC3457934.



39: Lienlaf M, Hayashi F, Di Nunzio F, Tochio N, Kigawa T, Yokoyama S,

Diaz-Griffero F. Contribution of E3-ubiquitin ligase activity to HIV-1

restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha. J

Virol. 2011 Sep;85(17):8725-37. doi: 10.1128/JVI.00497-11. Epub 2011 Jul 6.

PubMed PMID: 21734049; PubMed Central PMCID: PMC3165826.



40: Diaz-Griffero F, Gallo DE, Hope TJ, Sodroski J. Trafficking of some old world

primate TRIM5α proteins through the nucleus. Retrovirology. 2011 May 15;8:38.

doi: 10.1186/1742-4690-8-38. PubMed PMID: 21575157; PubMed Central PMCID:




41: Diaz-Griffero F. Caging the beast: TRIM5α binding to the HIV-1 core. Viruses.

2011 May;3(5):423-8. doi: 10.3390/v3050423. Epub 2011 Apr 27. PubMed PMID:

21994740; PubMed Central PMCID: PMC3186010.



42: Sastri J, O'Connor C, Danielson CM, McRaven M, Perez P, Diaz-Griffero F,

Campbell EM. Identification of residues within the L2 region of rhesus TRIM5alpha

that are required for retroviral restriction and cytoplasmic body localization.

Virology. 2010 Sep 15;405(1):259-66. doi: 10.1016/j.virol.2010.06.015. Epub 2010

Jul 14. PubMed PMID: 20633914; PubMed Central PMCID: PMC2914212.



43: Peña-Cruz V, McDonough SM, Diaz-Griffero F, Crum CP, Carrasco RD, Freeman GJ.PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity. J Invest Dermatol. 2010 Sep;130(9):2222-30. doi: 10.1038/jid.2010.127. Epub 2010 May 6. PubMed PMID: 20445553; PubMed Central

PMCID: PMC2927196.



44: Gosselin A, Monteiro P, Chomont N, Diaz-Griffero F, Said EA, Fonseca S,

Wacleche V, El-Far M, Boulassel MR, Routy JP, Sekaly RP, Ancuta P. Peripheral

blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1

infection. J Immunol. 2010 Feb 1;184(3):1604-16. doi: 10.4049/jimmunol.0903058.

Epub 2009 Dec 30. PubMed PMID: 20042588; PubMed Central PMCID: PMC4321756.



45: Mani M, Carrasco DE, Zhang Y, Takada K, Gatt ME, Dutta-Simmons J, Ikeda H,

Diaz-Griffero F, Pena-Cruz V, Bertagnolli M, Myeroff LL, Markowitz SD, Anderson

KC, Carrasco DR. BCL9 promotes tumor progression by conferring enhanced

proliferative, metastatic, and angiogenic properties to cancer cells. Cancer Res.

2009 Oct 1;69(19):7577-86. doi: 10.1158/0008-5472.CAN-09-0773. Epub 2009 Sep 8. PubMed PMID: 19738061; PubMed Central PMCID: PMC4321734.



46: Diaz-Griffero F, Qin XR, Hayashi F, Kigawa T, Finzi A, Sarnak Z, Lienlaf M,

Yokoyama S, Sodroski J. A B-box 2 surface patch important for TRIM5alpha

self-association, capsid binding avidity, and retrovirus restriction. J Virol.

2009 Oct;83(20):10737-51. doi: 10.1128/JVI.01307-09. Epub 2009 Aug 5. PubMed

PMID: 19656869; PubMed Central PMCID: PMC2753111.



47: Torimiro JN, Javanbakht H, Diaz-Griffero F, Kim J, Carr JK, Carrington M,

Sawitzke J, Burke DS, Wolfe ND, Dean M, Sodroski J. A rare null allele

potentially encoding a dominant-negative TRIM5alpha protein in Baka pygmies.

Virology. 2009 Aug 15;391(1):140-7. doi: 10.1016/j.virol.2009.05.038. Epub 2009

Jul 3. PubMed PMID: 19577266; PubMed Central PMCID: PMC2760473.



48: Kar AK, Diaz-Griffero F, Li Y, Li X, Sodroski J. Biochemical and biophysical

characterization of a chimeric TRIM21-TRIM5alpha protein. J Virol. 2008

Dec;82(23):11669-81. doi: 10.1128/JVI.01559-08. Epub 2008 Sep 17. PubMed PMID: 18799572; PubMed Central PMCID: PMC2583655.



49: Taube R, Zhu Q, Xu C, Diaz-Griffero F, Sui J, Kamau E, Dwyer M, Aird D,

Marasco WA. Lentivirus display: stable expression of human antibodies on the

surface of human cells and virus particles. PLoS One. 2008 Sep 11;3(9):e3181.

doi: 10.1371/journal.pone.0003181. PubMed PMID: 18784843; PubMed Central PMCID: PMC2527531.



50: Diaz-Griffero F, Perron M, McGee-Estrada K, Hanna R, Maillard PV, Trono D,

Sodroski J. A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to

restrict and prematurely uncoat B-tropic murine leukemia virus. Virology. 2008

Sep 1;378(2):233-42. doi: 10.1016/j.virol.2008.05.008. Epub 2008 Jun 30. PubMed

PMID: 18586294; PubMed Central PMCID: PMC2597210.



51: Diaz-Griffero F, Taube R, Muehlbauer SM, Brojatsch J. Efficient production of

HIV-1 viral-like particles in mouse cells. Biochem Biophys Res Commun. 2008 Apr

11;368(3):463-9. doi: 10.1016/j.bbrc.2007.12.195. Epub 2008 Jan 30. PubMed PMID:




52: Diaz-Griffero F, Kar A, Lee M, Stremlau M, Poeschla E, Sodroski J.

Comparative requirements for the restriction of retrovirus infection by

TRIM5alpha and TRIMCyp. Virology. 2007 Dec 20;369(2):400-10. Epub 2007 Oct 24.

PubMed PMID: 17920096; PubMed Central PMCID: PMC2153441.



53: Javanbakht H, Diaz-Griffero F, Yuan W, Yeung DF, Li X, Song B, Sodroski J.

The ability of multimerized cyclophilin A to restrict retrovirus infection.

Virology. 2007 Oct 10;367(1):19-29. Epub 2007 Jun 15. PubMed PMID: 17574642;

PubMed Central PMCID: PMC2065756.



54: Diaz-Griffero F, Kar A, Perron M, Xiang SH, Javanbakht H, Li X, Sodroski J.

Modulation of retroviral restriction and proteasome inhibitor-resistant turnover

by changes in the TRIM5alpha B-box 2 domain. J Virol. 2007 Oct;81(19):10362-78.

Epub 2007 Jul 11. PubMed PMID: 17626085; PubMed Central PMCID: PMC2045480.



55: Li X, Gold B, O'hUigin C, Diaz-Griffero F, Song B, Si Z, Li Y, Yuan W,

Stremlau M, Mische C, Javanbakht H, Scally M, Winkler C, Dean M, Sodroski J.

Unique features of TRIM5alpha among closely related human TRIM family members.

Virology. 2007 Apr 10;360(2):419-33. Epub 2006 Dec 6. PubMed PMID: 17156811.



56: Javanbakht H, Yuan W, Yeung DF, Song B, Diaz-Griffero F, Li Y, Li X, Stremlau

M, Sodroski J. Characterization of TRIM5alpha trimerization and its contribution

to human immunodeficiency virus capsid binding. Virology. 2006 Sep

15;353(1):234-46. Epub 2006 Jun 30. PubMed PMID: 16808955.



57: Diaz-Griffero F, Vandegraaff N, Li Y, McGee-Estrada K, Stremlau M, Welikala

S, Si Z, Engelman A, Sodroski J. Requirements for capsid-binding and an effector

function in TRIMCyp-mediated restriction of HIV-1. Virology. 2006 Aug

1;351(2):404-19. Epub 2006 May 2. PubMed PMID: 16650449.



58: Diaz-Griffero F, Li X, Javanbakht H, Song B, Welikala S, Stremlau M, Sodroski

J. Rapid turnover and polyubiquitylation of the retroviral restriction factor

TRIM5. Virology. 2006 Jun 5;349(2):300-15. Epub 2006 Feb 10. PubMed PMID:




59: Stremlau M, Perron M, Lee M, Li Y, Song B, Javanbakht H, Diaz-Griffero F,

Anderson DJ, Sundquist WI, Sodroski J. Specific recognition and accelerated

uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl

Acad Sci U S A. 2006 Apr 4;103(14):5514-9. Epub 2006 Mar 15. PubMed PMID:

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