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Faculty Profile

Eszter Lazar-Molnar, Ph.D.

Dr. Eszter Lazar-Molnar

Research Assistant Professor, Department of Microbiology & Immunology

 

Professional Interests

My research is focused on understanding the mechanism by which costimulatory molecules, such as PD-1 and its ligands regulate host responses to pathogens and malignancies, and finding new ways of designing immunotherapy.

 

Selected Publications

  1. Lazar-Molnar E, Chen B, Sweeney KA, Wang EJ, Liu W, Porcelli SA, Almo SC, Nathenson SG, Jacobs WR. Programmed death-1 (PD-1) Deficient Mice Are Extraordinarily Sensitive to Tuberculosis. PNAS, 107(30):13402-7, 2010.   Commentary in Nature Reviews Microbiology 8: 612, 2010 (Research Highlight). S. Molloy: Innate immunity: PD1 turns down the heat.
  2. Chattopadhyay K, Lazar-Molnar E, Yan Q, Rubinstein R, Zhan C, Bonanno J, Vigdorovich V, Ramagopal UA, Nathenson SG, Almo SC: Sequence, Structure, Function, Immunity: Structural Genomics of Costimulation. Immunological Reviews 229(1):356-86, 2009.
  3. Lazar-MolnarE*, YanQ*, Cao E*, RamagopalU, Nathenson SG, Almo SC. Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. PNAS, 105(30):10483-8, 2008.   Commentary in PNAS 105(30): 10275-6, 2008. G. J. Freeman: Structures of PD-1 with its ligands: Sideways and dancing cheek to cheek.
  4. Shi L, Albuquerque PC, Lazar-Molnar E, Wang X, Santambrogio L, Gácser A, Nosanchuk JD. A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophage. Eucaryotic Cell 7(7):1109-17, 2008.
  5. Lazar-Molnar E*, Gácser A*, Freeman GJ, Almo SC, Nathenson SG, Nosanchuk JD. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. PNAS 105(7):2658-63, 2008.
  6. Lazar-Molnar E, Almo SC, Nathenson SG The interchain disulfide linkage is not a prerequisite but enhances CD28 costimulatory function. Cellular Immunology  244(2):125-9, 2006.
  7. Lazar-Molnar E, Hegyesi H, Pállinger É, Kovács P, Tóth S, Fitzsimons C, Cricco G, Martin G, Rivera E., Falus A.: Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6. European Journal of Clinical Investigation 32(10):743-9, 2002.
  8. Szincsak N, Hegyesi H, Hunyadi J, Martin G, Lazar-Molnar E, Kovacs P, Rivera E, Falus A, Juhasz I. Cimetidine and a tamoxifen derivate reduce tumour formation in SCID mice xenotransplanted with a human melanoma cell line. Melanoma Research 12(3):231-40, 2002.
  9. Molnar L. E, Cricco G, Martin G, Darvas Zs, Hegyesi H, Fitzsimons C, Bergoc R, Falus A, Rivera E: Histamine as a potential autocrine regulator of melanoma. Inflammation Research  50 Supplement 2, S102-103, 2001. 
  10. Falus A, Hegyesi H, Lazar-Molnar E, Pós Z, László V, Darvas Zs.: Duality of paracrine/autocrine interactions around melanoma; histamine is a relevant player in local regulation. Trends in Immunology 22: 648-52, 2001.
  11. Molnar L. E, Hegyesi H, Tóth S, Darvas Zs, Laszlo V, Szalai Cs, Falus A: Biosynthesis of interleukin-6, an autocrine growth factor for melanoma is regulated by melanoma derived histamine. Seminars in Cancer Biology 10: 25-28, 2000.
  12. Lazar-Molnar E, Hegyesi H, Tóth S, Falus A: Autocrine and paracrine regulations by cytokines and growth factors in melanoma. Cytokine 12: 547-554, 2000.

 

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Chanin Building, Room 407
Bronx, NY 10461

Tel: 718.430.3657
Fax: 718.430.8574
eszter.lazar-molnar@einstein.yu.edu

 
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