Associate, Department of Biochemistry
My main research focus is the effect of high fat feeding during gestation, weaning and throughout the adulthood of mice. By using a murine model that is genetically predisposed to developing diabetes, we hope to learn more about the direct effect of a maternal high fat diet (HFD) on the offspring during gestation and early life. Exposing them to varying dietary fat content (amount and type of fat) and adding antioxidants to the maternal diet allows us to alter the disease susceptibility of the offspring. I also want to determine whether or not these pups, when further exposed to a high fat diet during adulthood, develop a compensatory mechanism in which they become protected in an otherwise nutritionally stressful environment. The results of these studies may alter the guidelines recommended for a healthy pregnancy/postpartum diet. By examining epigenetic modifications in the setting of a high maternal HFD may provide an important link between the prenatal environment and increased susceptibility to adult disease.
Heyman , L., Seki, Y., Storm, P., Jones, H., Charron, M.J., Berger, K., Holm, C. Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. J Nutr Biochem. 2015 Sep 2. pii: S0955-2863(15)00223-5. doi: 10.1016/j.jnutbio.2015.08.022.
Chi, Y., Jasmin, J., Seki, Y., Lisanti, M., Charron, M.J., Lefer, D., Schuster, V. Inhibition of the prostaglandin transporter PGT lowers blood pressure in hypertensive rats and mice. PLoS One. 2015 Jun 29;10(6):e0131735. doi: 10.1371/journal.pone.0131735.
Atkins, K*., Seki, Y*., Saha, J., Eichinger, F., Charron, M.J., Brosius, F.C. Maintenance of GLUT4 expression in smooth muscle prevents hypertension-induced changes in vascular reactivity. Physiol Rep. 2015, 3 (1), e12299. (*KA and YS made equal contributions).
Plata, M., Williams, L., Seki, Y., Hartil, K., Kaur, H., Lin, C., Fiallo, A., Glenn, A.S., Katz, E.B., Fuloria, M., Charron, M.J., Vuguin, P.M. Critical periods of increased fetal vulnerability to adverse metabolic programming by a maternal high Fat diet in CD1 mouse model. Reprod Biol Endocrinol. 2014 Aug 18;12(1):80.
Lin, C.L., Williams, L., Seki, Y., Kaur, H., Hartil, K., Fiallo,A., Glenn, A.S., Katz, E.B., Charron, M.J., Vuguin, P.M. 2014. Effects of genetics and in utero diet on murine pancreatic development. J Endocrinol 222(2):217-27.
Williams, L*., Seki, Y*., Vuguin, P.M., Charron, M.J. 2013. Animal models of in utero exposure to a high fat diet. Biochimi Biophys Acta 2013 S0925-4439 (13) 00246-9. (*LW and YS made equal contributions).
Kruse, M., Seki, Y., Du, X., Fiallo, A., Glenn, A., Singer, S., Breuhahn, K., Katz, E.B., Charron, M.J. 2013. High fat intake during pregnancy and lactation exacerbates high fat diet induced complications in male offspring in mice. Endocrinology 154(10): 3565-76.
Vuguin, P.M., Hartil, K., Kruse, M., Kaur, H., Chia-Lei, L., Scott, A.S., Fiallo, A., Patel, A., Williams, L., Seki, Y., Katz, E.B., Charron M.J. 2013. Shared effects of genetic and intrauterine environment on the development of metabolic syndrome. PloS One 17;8(5): e63021.
Seki, Y., Williams, L., Vuguin, P.M., Charron, M.J. 2012. Epigenetic programming of diabetes and obesity: animal models. Endocrinology 153, 1031–1038.
Seki, Y., Berggren, JA., Houmard, JA., Charron, M.J. 2006. Glucose transporter expression in skeletal muscle of endurance-trained individuals. Med Sci Sport Exer 38, 1088-1092.
Seki, Y., Sato, K., Akiba, Y. 2005. Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens. Comp Biochem Physiol B 142, 201-208.
Seki, Y., Sato, K., Kono, T., Abe, H., Akiba, Y. 2003. Broiler chickens (Ross Strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA. Gen Comp Endocrinol 133, 80-87.
Seki, Y., Sato, K., Ohtsu, H., Akiba, Y. 2001. Persistent hypoglycemia is induced by tolbutamide administration in broiler chickens fed a low-carbohydrate diet. Domest Anim Endocrinology 20, 109-122.
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Albert Einstein College of Medicine
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