Faculty Profile

Dr. Gil Atzmon, Ph.D.

Gil Atzmon, Ph.D.

Associate Professor, Department of Medicine (Endocrinology)

Associate Professor, Department of Genetics

Areas of Research: My research focus is on the role of epigenetics in diseases, aging and longevity.

Professional Interests

Dr. Gil Atzmon is currently an Associate Professor in the Division of Endocrinology, Departments of Medicine and Genetics at Albert Einstein College of Medicine, New York, USA. He is also a member of the Institute for Aging Research (IAR) and the Diabetes Research and Training Center (DRTC) at Albert Einstein College of Medicine. A graduate in Population Genetics from Hebrew University, he completed his fellowship in Human Genetics at Albert Einstein College of Medicine where he then joined as a faculty and rose to the rank of Associate Professor. As Associate Professor of Medicine at Einstein, Dr. Atzmon's focus is in a new and challenging field involving the role of epigenetics in diseases, aging and longevity. Dr. Atzmon's work has provided the foundation for the genetic approaches of the Institute of Aging. The foremost focus of Dr. Atzmon's research career has been the understanding of the association of the whole genome to disease, performance, health and longevity. Dr. Atzmon has international collaborated with scientists and researchers across the world. He had more than 110 scientific publications in leading scientific journals. He was invited to present his work in numerous international scientific conferences and meetings. He has been an expert reviewer for many leading scientific journals on genetics and genomics. He is also on the editorial board of couple of journals including the International Journal of Case Report and Images.

Selected Publications

  1. Deluty JA, Atzmon G, Crandall J, Barzilai N, Milman Sofiya. The influence of gender on inheritance of exceptional longevity. Aging, 7(6), 2015,
  2. Kato K, Zweig R, Schechter CB, Barzilai Nir, Atzmon G. Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians. Aging & Mental Health, 2015.
  3. Govindaraju D, Atzmon G, Barzilai N. Genetics, lifestyle and longevity: Lessons from centenarians. Applied & Translational Genomics, 4, 23-32, 2015.
  4. Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. BJC, 112(2): 313-318, 2015.
  5. Han J, Atzmon G, Barzilai N, Suh Y. Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews. Translational Research, 65 (4), 480-481, 2015.
  6. Gutman D, Sharvit L and Atzmon G. Possible Mechanisms for Telomere Length Maintenance in Extremely Old People. Hereditary Genet, 3, e11, 2014.
  7. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI. on behalf of T2D-GENES; Boehnke M. on behalf of GoT2D; Altshuler D. on behalf of SIGMA T2D, Tuomileheto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL. Age-related clonal hematopoiesis associated with adverse outcomes. NEJM, 371 (26), 2488-2498, 2014.
  8. Gershoni M, Toiw Y, Ovadia O, Levin L, Shani N, Dadon S, Atzmon G, Wainstein J, Tsur A, Nijtmans L, Glaser B, Mishmar D. Interfering with nucleus-mitochondrial co-evolution disrupts OXPHOS complex I integrity and alters risk to type 2 diabetes mellitus. GBE, 6(10):2665-80, 2014.
  9. Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB; GoT2D Consortium; NHGRI JHS/FHS Allelic Spectrum Project; SIGMA T2D Consortium; T2D-GENES Consortium, Rosen ED, Altshuler D; GoT2D Consortium. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. PNAS. 111(36):13127-32, 2014.
  10. Zidan J, Ben-Avraham D, Carmi S, Maray  T, Friedman E, Atzmon G. Genotyping of geographically diverse Druze trios reveals substructure and a recent bottleneck. EJHG, 2014.
  11. Carmi S, Hui KY, Kochav E, Liu X, [….] Ostrer H, Atzmon G, Clark LN, Lencz T, Pe’er I. Whole genome sequencing of an Ashkenazi Jewish reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nature Communication. 5:4835, 2014.
  12. Eny KM, Lutgers HL, Maynard J, Klein B, Lee KE, Atzmon G., Monnier VM, van Vliet – Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini MS, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K, Klein R, Crandall JP, Barzilai N, Milman S, Ben-Avraham D, LifeLines Cohort Study, DCCT/EDIC Research Group, Wolffenbuttel BHR, Paterson AD. GWAS identifies the N-acetyltransferase 2 (NAT2) acetylator status tag SNP to be a major locus for skin fluorescence. Diabetologia. 57(8):1623-34, 2014.
  13. Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P. Disease Variants in Genomes of 44 Centenarians. MGGM, 2(5):438-50, 2014.
  14. Friedman E, Moran DS, Ben-Avraham D, Yanovich R, Atzmon G. Novel candidate genes putatively involved in stress fracture predisposition detected by whole Exome sequencing. Genetics Research, 96:e004, 2014.
  15. Vacic V, Ozelius LJ, Clark LN, Bar-Shira A,  Gana-Weisz M, Gurevich T, Gusev A, Kedmi M, Kenny EE, Liu X, Mejia-Santana H, Mirelman A, Raymond D, Saunders-Pullman R, Desnick RJ, Atzmon G, Burns ER, Ostrer H, Hakonarson H, Bergman A, Barzilai N, Darvasi A, Peter I, Guha S, Lencz T, Giladi N, Marder K,  Pe’er I, Bressman SB, Orr-Urtreger A. Genome-wide mapping of identical-by-descent segments in an Ashkenazi Parkinson disease cohort identifies associated haplotypes. Human Molecular Genetics. 23(17):4693-702, 2014.
  16. Bashiri A, Heo HJ, Mazor M, Budagov T, Einstein FH,  Atzmon G. Pregnancy Complicated by Obesity Induces Global Dysregulation in Visceral and Subcutaneous Fat. Molecular Genetics and Genomics. 289(4):695-705, 2014.
  17. Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. Low Insulin-like Growth Factor-1 Level Predicts Survival in Humans with Exceptional Longevity. Aging Cell, 13(4):769-71, 2014.
  18. Flannick J, Thorleifsson G, Beer NL, Jacobs SBR, Grarup N, Mahajan A, Fuchsberger C, Atzmon G, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nature genetics, 46(4):357-63, 2014.
  19. Atzmon G, Chang ALS, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N. Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study. Journal of Investigative Dermatology, 134(3):651-7, 2014.
  20. Milman S, Schulder-Katz M, Deluty J, Zimmerman ME, Crandall JP, Barzilai N, Melamed ML, Atzmon G. Individuals with Exceptional Longevity Manifest a Delayed Association between Vitamin D Insufficiency and Cognitive Impairment. J Am Geriatr Soc. 62(1):153-8, 2014.
  21. The SIGMA Type 2 Diabetes Consortium; Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C [….]; T2D-GENES Consortium, Flannick J, Fontanillas P, Morris A, Teslovich TM, Burtt NP, Atzmon G, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature, 506(7486):97-101, 2014.
  22. Barzilai N, Atzmon G. Annual Review of Gerontology and Geriatrics, 34 (1): 171-188, 2014.
  23. Milman S, Atzmon G, Crandall J, Barzilai N. Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity. Curr Vasc Pharmacol. 12(5):690-7, 2014.
  24. Botigué LR, Henn BM, Gravel S, Maples BK, Gignoux CR, Corona E, Atzmon G, Burns E, Ostrer H, Flores C, Bertranpetit J, Comas D, Bustamante CD. Gene flow from North Africa contributes to differential human genetic diversity in southern Europe. PNAS, 110(29):11791-6, 2013.
  25. Kato K, Zweig R, Schechter CB, Verghese J, Barzilai N, Atzmon G. Personality, Self-Rated Health, and Cognition in Centenarians: Do Personality and Self-Rated Health Relate to Cognitive Function in Advanced Age?. Aging, 5(3):183-91, 2013.
  26. Axelrad MD, Atzmon G. Epigenomic of Aging. Hereditary Genetics, 2013.
  27. Axelrad MD, Budagov T, Atzmon G. Telomere length and telomerase activity; a yin and yang of cell senescence. J Vis Exp, (75). 2013.
  28. Wan J, Atzmon G, Hwang D, Barzlai N, Kratzsch J, Cohen P. Growth Hormone Receptor (GHR) Exon 3 Polymorphism Status Detection by Dual-Enzyme-Linked Immunosorbent Assay (ELISA). JCEM, 98(1): E77-E81, 2013.
  29. Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. Mechanisms of Ageing and Dev. 134(10):478-85, 2013.
  30. Huffman DM, Augenlicht LH. , Zhang X, Lofrese JJ, Atzmon G, Chamberl JP. Mantzoros CS. Abdominal obesity, independently from caloric intake, accounts for the development of intestinal tumors in Apc1638N/+ female mice. Cancer Prevention Research, 6(3):177-87, 2013.
  31. Mirina A, Atzmon G, Ye K, Bergman A. Gene Size Matters. PLoS One, 7(11):e49093, 2012.
  32. Ben-Avraham D, Muzumdar RH, Atzmon G. Epigenetic-genome wide association (EWAS) methylation in aging and longevity. Epigenomics, 4(5):503-9, 2012.
  33. Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JHJ, Campisi J, Vijg J, Suh Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC genomics, 13(1):353, 2012.
  34. Campbell CL, Palamara PF, Dubrovsky M, Botigué LR, Fellous M, Atzmon G, Oddoux C, Pearlman A, Hao L, Henn BM, Burns E, Bustamante CD, Comas D, Friedman E, Pe'er I, Ostrer H. North African Jewish and non-Jewish populations form distinctive, orthogonal clusters. PNAS, 109(34):13865-70, 2012.  
  35. Kato K, Zweig R, Barzilai N, Atzmon G. Positive Attitude Towards Life and Emotional Expression as Personality Phenotypes for Centenarians. Aging, 4(5):359-67, 2012.
  36. Broer L, Demerath EW, Garcia ME, Homuth G, Kaplan RC, Lunetta KL, Tanaka T, Tranah GJ, Walter S, Arnold AM, Atzmon G, Harris TB, Hoffmann W, Karasik D, Kiel DP, Kocher T, Launer LJ, Lohman KK, Rotter JI, Tiemeier H, Uitterlinden AG, Wallaschofski H, Bandinelli S, Dörr M, Ferrucci L, Franceschini N, Gudnason V, Hofman A, Liu Y, Murabito JM, Newman AB, Oostra BA, Psaty BM, Smith AV, van Duijn CM. Association of heat shock proteins with all-cause mortality. Age (Dordr). 35(4):1367-76, 2012.
  37. Huffman DM, Deelen J, Ye K, Bergman A, Slagboom EP, Barzilai N, Atzmon G. Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: The case of the MTP gene. J Gerontol A Biol Sci Med Sci. 67(11):1153-60, 2012.
  38. Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell, 11(3):475-81, 2012.
  39. Atzmon G, Lai JYC, Melamed ML, Hostetter TH, Crandall JP, Barzilai N, Bitzer M. Family History of Exceptional Longevity is associated with lower serum uric acid levels. JAGS, 60(4):745-50, 2012. 
  40. Kenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Meng Ng S, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi  N, Gregersen PK, Hakonarson H, Jones MR, McGovern DPB, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer  L, Katz S, Desnick RJ, Cho JH, Peter I. A Genome-Wide Scan of Ashkenazi Jewish Crohn’s Disease Suggests Novel Susceptibility Loci. PLoS Genetics, 8(3):e1002559, 2012.
  41. Tabatabaie V, Atzmon G, Rajpathak SN, Freeman R, Barzilai N, Crandall J. Exceptional longevity is associated with decreased reproduction. Aging, 3(12):1202-5, 2011.
  42. Hansen BC, Shamekh R, Budagov T, Linden E, Pessin J,  Atzmon G. The rhesus monkey: a nonhuman primate model for T2DM associated gene screening. J Diabetes Metab, 2:150. 2011.  
  43. Velez C, Palamara PF, Guevara-Aguirre J, Hao L, Karafet T, Guevara-Aguirre M, Pearlman A, Oddoux C, Hammer M, Burns E, Pe'er I, Atzmon G, Ostrer H. The Impact of Converso Jews on the Genomes of Modern Latin Americans. Human genetics, 131(2):251-63, 2012.
  44. Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, et al. A Genome-Wide Association Study of Ageing. Neurobiology of Aging, 32(11): 2109.e15-e28, 2011.
  45. Rajpathak SN, Liu J, Ben-David O, Reddy S, Atzmon G, Crandall J, Barzilai N. Lifestyle Factors among People with Exceptional longevity. JAGS, 59(8):1509-12, 2011.
  46. Moorjani P, Patterson N, Hirschhorn JN, Hao L, Atzmon G, Burns E, Keinan A, Osterer H, Price A, Reich D. The history of African gene flow into Southern Europeans, Levantines and Jews. PLoS Genet 7(4): e1001373, 2011.
  47. Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D and Bergman A. The promise of human genetics in preventing ageing-related disease. JCEM, 95(10):4493-500. Erratum in: JCEM. 2011;96(6):1908, 2010.
  48. Muzumdar RH, Huffman DM, Calvert JW, Jha S, Weinberg Y, Cui L, Nemkal A, Atzmon G, Gundewar S, Yong Ji S, Lefer DJ. Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice. ATVB. 30(10):1940-8, 2010.
  49. Einstein FH, Huffman DM, Fishman S, Jerschow E, Heo HJ, Atzmon G, Barzilai N, Muzumdar RH. Aging per se Increases the Susceptibility to Free Fatty Acid-Induced Insulin Resistance. J Gerontol A Biol Sci Med Sci. 65(8):800-8, 2010.
  50. Thompson RF, Atzmon G, Liang HQ, Lowes C, Greally JM, Barzilai N. Tissue-specific dysregulation of DNA methylation in aging. Aging cell, 9(4):506-18, 2010.
  51. Cai G, Atzmon G, Naj A, Beecham GW, Barzilai N, Haines JL, Sano M, Pericak-Vance M, Buxbaum JD. Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease. Neurobiology of Aging, 33(2):416-417.e3, 2012.
  52. Atzmon G, Hao L,  Pe'er I, Velez C, Pearlman A, Palamara P, Morrow B, Friedman E, Oddoux C, Burns E, Ostrer H. Abraham’s Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry. AJHG, 86(6):850–9, 2010.
  53. Schechter CB, Barzilai N, Crandall JP, Atzmon G. Reduced Cholesteryl Ester Transfer Protein Levels Is Associated with Decreased Blood Pressure. Mayo Clinic Proceeding, 85(6):522-6, 2010.
  54. Neuman RJ, Wasson J, Atzmon G, Sun L, Barzilai N, Blech I, Glaser B, Permutt MA.Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in Genetically Homogenous Versus Heterogeneous Populations. PLoS One, 26;5(3):e9903, 2010.
  55. Atzmon G, Cho M,Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, and Suh Y. Evolution in Health and Medicine Sackler Colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. PNAS, 107(1):1710-1717, 2010.
  56. Sebastiani P, Montano M, Puca A, Timofeev N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SEJ, Anderson S, Hartley S, Sedgewick A, Arai Yasumichi, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Steinberg MH,  Hirose N, Atzmon G, Ruvkun G, Baldwin CT & Perls TT. RNA Editing Genes Associated with Extreme Old Age in Humans and Lifespan in C. elegans. PLoS One, 4 (12): e8210, 2009.
  57. Atzmon G, Barzilai N, Surks MI, Gabriely l. Genetic Predisposition to Elevated Serum Thyrotropin is Associated with Exceptional Longevity. JCEM, 94(12):4768-75, 2009.
  58. Pawlikowska L, Hu Donglei, Huntsman S, Sung A, Chu C, Chen J, Reiner A, Atzmon G, Barzilai N, Psaty B, Hsueh W-C, Cummings S, Browner W, Kwok P-Y, Ziv E. Association of common genetic variation in the IGF1 signaling pathway with human lifespan. Aging cell, 8(4):460-72, 2009.
  59. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: a novel central regulator of peripheral insulin action. PLoS one, 4(7):e6334, 2009.
  60. Walston JD, Matteini AM, Nievergelt C, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, LaCroix A, Russell PT, Atzmon G, Lange EM, Reiner AP. Inflammation and Stress-Related Candidate Genes, Plasmainterleukin-6 Levels, and Longevity In Older Adults. Experimental Gerontology, 44(5):350-5, 2009.
  61. Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I. Extreme Longevity is Associated with Increased Serum Thyrotropin. JCEM, 94(4):1251-4, 2009.
  62. Shlush LI, Atzmon G, Weisshof R, Behar D, Yudkovsky G, Barzilai N, Skorecki K.  Ashkenazi Jewish Centenarians do not Demonstrate Enrichment in Mitochondrial Haplogroup J. PLoS One. 3(10):e3425, 2008.
  63. Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N.Visceral Adipose Tissue Modulates Mammalian Longevity. Aging Cell. 7(3):438-40, 2008.
  64. Einstein FH, Bauman J, Fishman S, Thompson R, Atzmon G, Barzilai N, Muzumdar RH. Enhanced Activation of ‘Nutrient-Sensing pathway’ with Age Contributes to the Insulin Resistance and Inflammatory State. FASEB. 22(10):3450-7, 2008.
  65. Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, Shuldiner AR, Barzilai N. Adiponectin levels and genotype: A potential regulator of life-span in humans. J Gerontol A Biol Sci Med Sci. 63(5):447-53, 2008.
  66. Atzmon G, Blum S, Feldman M, Cahaner A, Lavi U, Hillel J. QTLs detected in a multigenerational resource chicken population. Journal of Heredity. 99(5):528-38, 2008.
  67. Suh Y, Atzmon G, Cho M, Hwang D, Liu B, Leahy D, Barzilai N, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. PNAS. 105(9):3438-42, 2008.
  68. Einstein FH, Fishman S, Muzumdar R, Yang X, Atzmon G, Barzilai N. Accretion of Visceral Fat and Hepatic Insulin Resistance in Pregnant Rats. Am J Physiol Endocrinol Metab. 294(2):E451-5, 2008.
  69. Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G. Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. Mitochondrion 7(4):267-72, 2007.
  70. Atzmon G, Blum S, Feldman M, Lavi U, Hillel J. Detection of agriculturally important QTLs in chickens and identification of the best genotyping strategy. Cytogenet Genome Res 117:327–337, 2007.
  71. Fishman S, Muzumdar R, Atzmon G, Ma X, Barzilai N. Resistance to Leptin Action is the Major Determinant of Hepatic Triglycerides Accumulation in vivo. FASEB 21(1):53-60, 2007.
  72. Atzmon G, Rincon M, Schechter C, Shuldiner A, Lipton R, Bergman A, Barzilai N: Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biology 4(4):e113, 2006.
  73. Atzmon G, Ronin YI, Korol A, Yonash N, Cheng H and Hillel J. QTLs associated with growth traits and abdominal fat weight and their interactions with gender and hatch in commercial meat-type chickens. Animal Genetics 37:352–358, 2006.
  74. Lahav T, Atzmon G, Blum S, Ben-Ari G, Weigend S, Cahaner A, Lavi U, Hillel J. Marker Assisted Selection Based On Multi-Trait Economic Index In Chicken: Experimental Results And Simulation. Animal Genetics 37: 482–488, 2006.
  75. Muzumdar R, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N. Central and Opposing effects of IGF-1 and IGFBP-3 on systemic insulin action. Diabetes 55:2788-96, 2006.
  76. Terry DF, Diego FW, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL,  Wilcox MA, Farrer LA, Perls TT, Barzilai N, Baldwin CT, Asea A, Serum Heat Shock Protein 70 Level as a Biomarker of Exceptional Longevity. Mechanisms of Aging and Dev. 127(11):862-8, 2006.
  77. Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB, A Genotype of Exceptional Longevity is Associated with Preservation of Cognitive Function. Neurology 26;67(12):2170-5, 2006.
  78. Bergman A, Atzmon G, Ye K, Barzilai N: Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Computational Biology, 3(8):e170, 2007.
  79. Muzumdar RH, Ma X, Yang X, Atzmon G, Barzilai N: Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging. Neurobiol Aging, 27:9:1308-1314, 2006.
  80. Atzmon G, Einstein FH, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N: Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes 54:672-678, 2005.
  81. Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC: Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 96:412-418, 2005.
  82. Atzmon G, Rincon M, Rabizadeh P, Barzilai N: Biological evidence for inheritance of exceptional longevity. Mech Ageing Dev 126:341-345, 2005.
  83. Rincon M, Muzumdar R, Atzmon G, Barzilai N: The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech Ageing Dev 125:397-403, 2004.
  84. Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N: Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. Diabetes 53:441-446, 2004.
  85. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N: Clinical phenotype of families with longevity. JAGS 52:274-277, 2004.
  86. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR: Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290:2030-40, 2003.
  87. Muzumdar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzilai N: Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J 17:1130-1132, 2003.
  88. Ma X, Muzmudar R, Gabriely I, Atzmon G, Barzilai N. Does the brain lead the metabolic decline in aging?: Lessons from animal models and human centenarians. Clinical Neuroscience Research.  2(5-6): 269-362, 2003.
  89. Atzmon G, Yang XM, Muzumdar R, Ma XH, Gabriely I, Barzilai N: Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res 34:622-628, 2002.
  90. Atzmon G, Gabriely I, Greiner W, Davidson D, Schechter C, Barzilai N: Plasma HDL levels highly correlate with cognitive function in exceptional longevity. J Gerontol A Biol Sci Med Sci 57:M712-715, 2002.
  91. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N: Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51:2951-2958, 2002.
  92. Atzmon G, Cassuto D, Lavi U, Cahaner A, Zeitlin G, Hillel J: DNA markers and crossbreeding scheme as means to select sires for heterosis in egg production of chickens. Anim Genet, 33:132-9, 2002.
  93. Atzmon G, Van Oss H, Cxosnek H: PCR-amplification of tomato yellow leaf curl virus (TYLCV) DNA from squashes of plants and whitefly vectors: application to the study of TYLCV acquisition and transmission. European Journal of Plant Pathology 104:189-194, 1998.

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Research Information

Media Coverage

The New York Times interviews Dr. Gil Atzmon and Dr. Nir Barzilai about their study linking longevity with a common genetic mutation in men.

BBC News interviews Dr. Harry Ostrer and The New York Times cites Dr. Gil Atzmon's research in two articles about a new study on Jewish genetic history.

More media coverage