Professor, Department of Medicine (Gastroenterology & Liver Diseases)
Professor, Department of Pathology
The Eleazar & Feige Reicher Chair in Translational Medicine, Department of Medicine
Our laboratory focuses on the development of liver cell-based therapies and relevant aspects of stem cell biology. Major goals are directed towards understanding mechanisms by which transplanted cells engraft, proliferate and function in the liver, obtaining insights into cell-cell interactions that may alter the fate of transplanted cells, and addressing the potential of liver cell types that might improve liver repopulation. The laboratory works with stem/progenitor cells isolated from fetal human tissues and uses such cells for studies of gene regulation, cell differentiation and therapeutic gene expression, including induction of pancreatic beta cell function.
A variety of rodent models, including various inbred mouse strains, the hemophilia A mouse, the Gunn rat, the Nagase analbuminemic rat, the dipeptidyl peptidase IV deficient (DPPIV-) rat and the DPPIV- mouse, the Long-Evans Cinnamon rat, etc., are available for studies. Several animals constitute unique genetic models for studying hepatic pathophysiology. Animal models, where acute or chronic liver injury is induced with toxins, including cell cycle regulators, are available. The DPPIV- rat and mouse-based transplantation systems have been very helpful for analyzing the fate of transplanted adult and fetal hepatocytes, as well as stem/progenitor cells. Studies are conducted to examine whether liver repopulation with hepatocyte transplantation could offer metabolic function in chronic liver disease and improve survival in animals with liver failure. Related studies are aimed at propagating subsets of stem/progenitor cells from fetal human tissues and analyzing mechanisms of cell differentiation, including after transplantation in immunodeficient animals. Some studies utilize microarray-based gene expression analysis and others use established cell and molecular biology methods. Further studies concern mechanisms of gene transfer with lentiviral vectors. Additional studies are aimed at developing novel models of human disease. The overall effort is aimed at translating basic research findings into clinical studies in people.
The laboratory collaborates with a number of leading investigators at Einstein or elsewhere as necessary.
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Ullmann Building, Room 625
Bronx, NY 10461