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Faculty Profile

Norman Fleischer, M.D.

Dr. Norman Fleischer

Professor, Department of Medicine (Endocrinology)

Jacob A. and Jeanne E. Barkey Chair in Medicine

Chief, Division of Endocrinology, Department of Medicine

Co-Director, Diabetes Research Center

 

Professional Interests

Norman Fleischer is the Barkey Professor of Medicine, Director of Endocrinology, and Co-Director of the Diabetes Research Center of the Montefiore Medical Center and Albert Einstein College of Medicine. A graduate of the Vanderbilt University School of Medicine, he completed his residency in Medicine at Jacobi Medical Center, and his Fellowship in Endocrinology at Vanderbilt under the mentorship of Grant W. Liddle, M.D. He then joined the faculty of Baylor College of Medicine in Houston, Texas, where he served as Chief of Endocrinology at Ben Taub General Hospital. At Baylor, he rose to the rank of Associate Professor of Medicine, remaining there until 1973, when he joined the faculty at Albert Einstein College of Medicine.

In 1976, he was appointed Director of the Division of Endocrinology at Einstein, and in 1977 became the founding Director of the NIH-funded Diabetes Research and Training Center. In 1988, Dr. Fleischer was appointed Director of the Diabetes Research Center of the Albert Einstein College of Medicine, a quasi-departmental University based center. In 1999, he was also appointed Director of Endocrinology of Montefiore Medical Center. Dr. Fleischer continues an active career in clinical endocrinology, research, and administration, with continuous involvement in the educational programs for students, residents, and especially, endocrine fellows.

His research is on the regulation of polypeptide hormone production and secretion, especially that of insulin. He studies the mechanisms involved in glucose, fatty acid, and incretin-mediated insulin secretion. For these studies he has utilized conditionally transformed murine beta cell lines in which replication is controllable. These cells are also studied by Dr. Fleischer as model systems for beta cell transplantation to treat diabetes.

 

Selected Publications

SELECTED PUBLICATIONS

Erlichman, J., Litvin, Y., and Fleischer, N.:Immunological and Molecular Characterization of cAMP‑dependent Protein Kinases in AtT‑20 cells. J. Biol. Chem. 259: 10289‑10295, 1984.

Leiser, M., Fleischer, N. and Erlichman, J.: Enhanced Activation of cAMP-dependent Protein Kinase by Rapid Synthesis and Degradation of cAMP. J. Biol. Chem. 261: 15486-15490, 1986.

Leiser, M., Fleischer, N. and Erlichman, J.: Enhanced Activation of cAMP-dependent Protein Kinase by Rapid Synthesis and Degradation of cAMP. J. Biol. Chem. 261: 15486-15490, 1986.

Bilezikjian, L.M., Erlichman, J., Fleischer, N. and Vale, W.W.: Differential activation of type I and type II cAMP-dependent protein kinases by growth hormone releasing factor. Molecular Endocrinology 1: 137-146,1987.

Fleischer, N., Liker, H., Stoller, T., and Shields, D.: Retrovirus-Mediated Expression of Preprosomatostatin in Rat Pituitary GH3 Cells: Targeting of somatostatin to the regulated secretory pathway. Molecular Endocrinology. 3:1652-1658, 1989.

Lomasky, S.J., D'Eramo, G., Shamoon, H. and Fleischer, N.: Relation of Insulin Secretion and Glycemic Recovery to Dietary Intervention in Non-Insulin-Dependent Diabetes. Arch. Intern. Med. 150:169-172, 1990.

Efrat, S., Fleischer, N., and Hanahan, D.: Diabetes Induced in Male Transgenic Mice by Expression of Human H-ras Oncoprotein in Pancreatic ©¬ Cells. Mol. Cell. Biol. 10: 1779-1783, 1990.

D'Ambra, R.D., Surana, M., Efrat, S., Starr, R.G., and Fleischer, N.: Regulation of Insulin Secretion from Beta Cell Lines Derived from Transgenic Mice Insulinomas Resembles That of Normal Beta Cells. Endocrinology 126: 2815-2822, 1990.

Efrat, S., Surana, M., and Fleischer, N.: Glucose induces insulin gene transcription in a murine ©¬-cell line. J. Biol. Chem., 266:11141-11143, 1991.

Tal, M., Thorens, B., Surana, M., Fleischer, N., Lodish, H. F., Hanahan, D., Efrat, S.: Glucose transporter isotypes switch in transformed pancreatic ©¬ cells. Mol. and Cell. Biol. 12:422-432, 1992.

Tal, M., Wu, Y-J, Leiser, M., Surana, S., Lodish, H., Fleischer, N., Weir, G., and Efrat, S.: [Val12]HRAS downregulates GLUT2 in ©¬ cells of transgenic mice without affecting glucose homeostasis. Proc. Natl. Acad. Sci. USA, 89:5744-5748, 1992.

Efrat, S., Leiser, M., Surana, M., Tal, M., Fusco-DeMane, D., and Fleischer, N.: A murine insulinoma cell line with normal glucose-regulated insulin secretion. Diabetes 42:901-907, 1993

Efrat, S., Leiser, M., Wu, Y-J., Fusco-DeMane, D., Emran, O., Surana. M., Weir, G., Jetton, T., Magnuson, M.A., and Fleischer, N.: Ribozyme-mediated attenuation of pancreatic ©¬-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci (USA), 91:2051-2055, 1994.

Knaack, D., Fiore, D.M., Surana, M., Leiser, M., Laurance, M., Fusco-DeMane, D., Fleischer, N., and Efrat, S.: Clonal insulinoma cell line which maintains correct glucose responsiveness. Diabetes 43:1413-1417, 1994

Leiser, M., Efrat, S., and Fleischer, N.: Evidence that RAP1 carboxylmethylation is involved in regulated insulin secretion. Endocrinology 136: 2521-2530, 1995.

Bali, D., Svetlanov, A., Lee, H., Fusco-DeMane, D., Leiser, M., Li, B., Barzilai, N., Surana, M., Hou, H., Fleischer, N., DePinho, R., Rossetti, L., and Efrat, S.: Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270:21464-21467, 1995.

Leiser, M., and Fleischer, N., cAMP-Dependent Phosphorylation of the Cardiac-type a1 Subunit of the Voltage-dependent Ca++ Channel in a Murine Pancreatic ©¬-Cell Line. Diabetes 45:1412-1418, 1996.

Fleischer, N., Chen, C., Surana, M., Leiser, M., Rossetti, L., Pralong, W., and Efrat, S., Functional Analysis of a Conditionally-Transformed Pancreatic ©¬-Cell Line. Diabetes 47:1419-1425, 1998.

Han P, Werber J, Surana M, Fleischer N and Michaeli T:The calcium calmodulin dependent phosphodiesterase PDE1C down‑regulates glucose induced insulin secretion. J. Biol. Chem. 274:22337‑44, 1999.

Sooy K, Schermerhorn T, Noda M, Rhoten WB, Meyer M, Fleischer N, Sharp GWG, Christakos S: Calbindin-D28k controls [Ca2+]i and insulin release: evidence obtained from calbindin-D28k knockout mice and cell lines. J.Biol. Chem., 274:34343-49, 1999.

Efrat S, and Fleischer N: Engineering the pancreatic ¥â-cell. In Diabetes Mellitus (D. LeRoith, S. Taylor, J. Olefsky, eds.) Lippincott-Raven, Philadelphia, p535-541, 2000

Cases, JA, Gabriely I, Xiao HM, Xiao MY, Michaeli T, Fleischer N, Rossetti L, Barzilai N: Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 50:348-352, 2001.

Milo-Landesman D, Surana M, Berkovich I, Compagni A, Christofori G, Fleischer N and Efrat S: Correction of hyperglycemia in diabetic mice transplanted with reversibly-immortalized pancreatic b cells controlled by the tet-on regulatory system. Cell Transplantation 10:645-659 (2001).

Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BJ, Karnieli O, Zern MA, Fleischer N, and Efrat S. Reversal of hyperglycemia in mice using human expandable insulin-producing cells differentiated from fetal liver progenitor cells; Proc. Natl. Acad. Sci.(USA), 100:7253-7258, 2003

Howard A, Floris-Moore M, Arnsten J, Santoro N, Fleischer N, Lo Yungtai, Schoenbaum E, Disorders of Glucose Metabolism among HIV-Infected Women Clinical Infectious Diseases 2005; 40:1491-9

Howard A, Floris-Moore M. Lo Y, Arnsten JH, Fleischer N, Klein RS, Abnormal glucose metabolism among older men with or at risk of HIV infection; 2006 British HIV Association; HIV Medicine (2006), 7, 389-396

Howard A, Lo Y, Floris-Moore M., Schoenbaum E, Fleischer N, Klein RS, Hepatitis C Virus Infection is Associated with Insulin Resistance among Older Adults with or At-Risk for HIV Infection. AIDS 2006 (in press).

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Belfer Building, Room 702
Bronx, NY 10461

Tel: 718.430.2908
Fax: 718.430.8557
norman.fleischer@einstein.yu.edu

 
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