Faculty Profile

Dr. Robert H. Singer, Ph.D.

Robert H. Singer, Ph.D.

Professor, Department of Anatomy & Structural Biology

Professor, Dominick P. Purpura Department of Neuroscience

Professor, Department of Cell Biology

Co-Chair, Department of Anatomy & Structural Biology

Harold and Muriel Block Chair in Anatomy & Structural Biology

Co-Director, Gruss-Lipper Biophotonics Center

Co-Director, Integrated Imaging Program

Areas of Research: We study single mRNA molecules from cradle to grave in single living cells using high resolution imaging. We develop trafficking microscopy and approaches to image RNA using fluorescent probes to visualize and quantify mRNA.

Professional Interests

Studying Single mRNA Molecules from Cradle to Grave
We seek to understand the expression and movement of mRNA from transcription through degradation and the effect that defects in these processes have on health. We develop methods to label RNA in fixed and living cells using fluorescent probes and develop microscopy techniques and image analysis algorithms to visualize and quantify many mRNAs simultaneously. Using these technologies, we can observe single mRNAs localizing to cytoplasmic compartments such as the leading edge of a fibroblast, the bud tip of yeast or the axonal process of neurons and follow these single mRNAs from transcription, nuclear export through translation and degradation. Because these techniques yield quantitative fluorescence data, we are able to apply mathematical modeling to test mechanistic hypotheses.

RNA Localization: Following Single mRNAs from Birth to Death in Living Cells

Selected Publications

Click this link to view the Singer Lab Publications

More Information About Dr. Robert Singer

Singer Laboratory Web Page

ASB Department Web Page

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 601
Bronx, NY 10461

Tel: 718.430.8646
Fax: 718.430.8697

Research Information

In the News

What Does it Look Like to 'Turn On' a Gene?

The research of Robert Singer, Ph.D., and colleagues has illuminated our understanding of gene activation, or transcription. Dr. Singer is professor and co-chair of anatomy & structural biology, the Harold and Muriel Block Chair in Anatomy & Structural Biology, and co-director of the Gruss-Lipper Biophotonics Center.

Science interviews Dr. Robert Singer, who is identified as a pioneer in the field of mRNA research, about the ongoing search to discover how proteins are placed in their correct destinations within a cell.

More media coverage