Faculty Profile

Dr. Robert H. Singer, Ph.D.

Robert H. Singer, Ph.D.

Professor, Department of Anatomy & Structural Biology

Professor, Dominick P. Purpura Department of Neuroscience

Professor, Department of Cell Biology

Co-Chair, Department of Anatomy & Structural Biology

Harold and Muriel Block Chair in Anatomy & Structural Biology

Co-Director, Integrated Imaging Program

Co-Director, Gruss-Lipper Biophotonics Center

Areas of Research: We study single mRNA molecules from cradle to grave in single living cells using high resolution imaging. We develop trafficking microscopy and approaches to image RNA using fluorescent probes to visualize and quantify mRNA.

Professional Interests

Studying Single mRNA Molecules from Cradle to Grave
We seek to understand the expression and movement of mRNA from transcription through degradation and the effect that defects in these processes have on health. We develop methods to label RNA in fixed and living cells using fluorescent probes and develop microscopy techniques and image analysis algorithms to visualize and quantify many mRNAs simultaneously. Using these technologies, we can observe single mRNAs localizing to cytoplasmic compartments such as the leading edge of a fibroblast, the bud tip of yeast or the axonal process of neurons and follow these single mRNAs from transcription, nuclear export through translation and degradation. Because these techniques yield quantitative fluorescence data, we are able to apply mathematical modeling to test mechanistic hypotheses.

Selected Publications

Click this link to view the Singer Lab Publications

More Information About Dr. Robert Singer

Singer Laboratory Web Page

ASB Department Web Page

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 601
Bronx, NY 10461

Tel: 718.430.8646
Fax: 718.430.8697
robert.singer@einstein.yu.edu

Research Information

Media Coverage

Science interviews Dr. Robert Singer, who is identified as a pioneer in the field of mRNA research, about the ongoing search to discover how proteins are placed in their correct destinations within a cell.

Nature interviews Robert Singer, Ph.D., about recent advances in single-cell imaging and the enormous benefits a core facility with this technology provides to an institution’s investigators, students and postdocs.

More media coverage