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Faculty Profile

Solomon L. Moshe, M.D.

Dr. Solomon L. Moshe

Professor, The Saul R. Korey Department of Neurology

Professor, Department of Pediatrics

Professor, Dominick P. Purpura Department of Neuroscience

Charles Frost Chair in Neurosurgery and Neurology

Director, Division of Pediatric Neurology, The Saul R. Korey Department of Neurology

Director, Clinical Neurophysiology, The Saul R. Korey Department of Neurology

Director, Division of Neurology, Department of Pediatrics

 

Professional Interests

Since 1979, Dr. Moshé’s research has focused on translational approaches to understand the mechanisms underlying the development of epilepsy and its consequences in infants and children. His laboratory has developed and patented an animal model that replicates human infantile spasms. In collaboration with Dr Aristea Galanopoulou, this model is being used to identify novel treatments of this devastating condition. His work has identified an endogenous brain circuit that can control the expression of seizures as a function of age and gender. In addition to his laboratory research, he is actively involved in several large, multi-center studies examining the outcomes of prolonged, febrile seizures (seizures occurring with fever) and absence epilepsy to identify predictive biomarkers of the course and response to treatment. In more than 20 years, Dr. Moshé has mentored numerous scientists and clinicians from around the world in clinical epilepsy and basic science epilepsy-related research.

 Dr. Moshé is active in numerous professional societies and elected President of the American Epilepsy Society, the American Clinical Neurophysiology Society, the Eastern Association of Electroencephalographers, and past President of The International League against Epilepsy. He is an elected member of the American Neurological Association and the American Pediatric Society

 

Selected Publications

 Moshe, S.L. In support of the ILAE Commission classification proposal. Epilepsia 52:1200-1 (2012).http://www.ncbi.nlm.nih.gov/pubmed/21770922 

 Arida, R.M., Scorza, F.A., Cavalheiro, E.A., Perucca, E., Moshé, S.L. Can people with epilepsy enjoy sports? Epilepsy Res. 98:94-95 (2012).http://www.ncbi.nlm.nih.gov/pubmed/21778037 

 Moshé, S.L., Perucca, E., Wiebe, S., Mathern, G.W. The International League Against Epilepsy at the Threshold of its second century: Year 2.  Epilepsia 53:215-219 (2012).http://www.ncbi.nlm.nih.gov/pubmed/22221160 

 Galanopoulou, A.S., Buckmaster, P.S., Staley, K., Moshé, S.L., Perucca, E., Engel, J., et al. Identification of new epilepsy treatments:  Issues in preclinical methodology. Epilepsia 53:571-82 (2012).http://www.ncbi.nlm.nih.gov/pubmed/22292566 

 Gulcebi, M.I., Ketenci, S., Linke, R., Hacioglu, H., Yanali, H., Veliskova, J., Moshe, SL, Onat, F., Cavdar, S. Topographical connections of the substantia nigra pars reticulate to higher-order thalamic nuclei in the rat.  Brain Res. Bull 87:312-18 (2012).

http://www.ncbi.nlm.nih.gov/pubmed/22108631 

 Cameron, A., Bansal, A., Dua, T., Hill, S., Moshé, S.L., Mantel-Teeuwisse, A., Saxena, S. Mapping the availability, price and affordability of antiepileptic medicines in 46 countries.  Epilepsia 53:962-69 (2012).http://www.ncbi.nlm.nih.gov/pubmed/22432967

  Avanzini, G., Manganotti, P., Meletti, S., Moshé, S.L., Panzica, F., Wolf, P., Capovilla, G. The system epilepsies: A pathophysiological hypothesis.  Epilepsia 53:771-778 (2012).http://www.ncbi.nlm.nih.gov/pubmed/22533642

  Shinnar, S., Bello, J.A., Chan, S., Hesdorffer, D., Lewis, D.V., MacFall, J.R., Pellock, J.M., Nordli, D.R. Moshe, S.L., et al. MR Imaging abnormalities following febrile status epilepticus in children: The FEBSTAT Study. Neurology:79(9):871-7 (2012).http://www.ncbi.nlm.nih.gov/pubmed/22843278

  Epstein, L., Shinnar, S., Hesdorffer, D.C., Nordli, D., Hamidullah, A., Benn, E., Pellock, J., Frank, M., Lewis, D., Moshé SL, Shinnar, R.C., Sun, S. Human Herpes virus 6 and 7 in Febrile Status Epilepticus: The FEBSTAT study. Epilepsia 1-8 (2012).http://www.ncbi.nlm.nih.gov/pubmed/22954016

  Hesdorffer, D., Shinnar, S., Lewis, D.V., Moshé SL, Nordli, D., Pellock, J.M., Macfall, J., Shinnar, R.C., Masur, D., Frank, L.M., Epstein, L.G., Litherland, C., Seinfeld, S.,  Bello, J., Chan, S., Bagiella, E., Sun, S. Design and Phenomenology of the FEBSTAT Study. Epilepsia 1-10 (2012). http://www.ncbi.nlm.nih.gov/pubmed/22742587

  Nordli, DR., Moshé SL Shinnar, S., Hesdorffer, D., Sogawa, Y., Pellock, J.M., Lewis, D.V., Frank, L.M., Shinnar, R.C., Sun, S.S. Acute EEG findings in children with febrile status epilepticus: Results of the FEBSTAT study. Neurology: 79(22):2180-6 (2012).http://www.ncbi.nlm.nih.gov/pubmed/23136262

  Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH, Jacques TS, Kahane P, Mathern GW, Miyata H, Moshé SL, Oz B, Ozkara C, Perucca E, Sisodiya S, Wiebe S, Spreafico R. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia.;54(7):1315-29 (2013). http://www.ncbi.nlm.nih.gov/pubmed/23692496

  Hesdorffer DC, Shinnar S, Lewis DV, Nordli DR Jr, Pellock JM, Moshé SL, Shinnar RC, Litherland C, Bagiella E, Frank LM, Bello JA, Chan S, Masur D, Macfall J, Sun S. Risk Factors for Febrile Status Epilepticus: A Case-Control Study. J Pediatr. (2013) (in press)http://www.ncbi.nlm.nih.gov/pubmed/23809042 

de Boer HM, Moshé SL.  ILAE/IBE/WHO Global Campaign Against Epilepsy: a partnership that works. Curr Opin Neurol. 26(2):219-25 (2013).http://www.ncbi.nlm.nih.gov/pubmed/23449175 

Sanmaneechai O, Song JL, Nevadunsky N, Moshé SL, Overby PJ. Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma. Pediatr Neurol. 48(3):232-5 (2013).http://www.ncbi.nlm.nih.gov/pubmed/23419475

  Sanmaneechai O, Sogawa Y, Silver W, Ballaban-Gil K, Moshé SL, Shinnar S. Treatment outcomes of West syndrome in infants with Down syndrome. Pediatr Neurol. 48(1):42-7. (2013).http://www.ncbi.nlm.nih.gov/pubmed/23290019

Gygax, M.J. and Moshé, SL. Animal models of early life seizures and epilepsies. Neurology Asia  18:5-7 (2013).

 Dlugos, D., Shinnar, S., Cnaan, A., Hu, F., Moshé, S., Mizrahi, E., Masur, D., Sogawa, Y., Levine, C., Hirtz, D., Clark, P., Adamson, P., Glauser, T. for the Childhood Absence Epilepsy Study Team. Pre-treatment EEG in newly diagnosed childhood absence epilepsy: Associations with neuropsychlogical status and initial treatment outcome. Neurology 81:150-156 (2013)

 Blumcke, I., Thom, M., Aronica, E., Armstrong, D.D., Bartolomei, F., Bernasconi, A., Bien, C.G., Cendes, F., Coras, R., Cross, H., Jacques, T.S., Kahane, P., Mathern, G.W., Miyata, H., Moshé, S.L., Oz, B., Ozkara, C., Perucca, E., Sisodiya, S., Wiebe, S., Spreafico, R. International Consensus Classification of Hippocampal Sclerosis in Temporal Lobe Epilepsy: A Task Force Report from the ILAE Commission on Diagnostic Methods. Epilepsia 54:1315-29 (2013).

 Moshé, SL, and Perucca, E. Epileptic Disorders to become the educational journal of ILAE. Epileptic Disorders 15:99 (2013).

 Ono, T, Galanopoulou, AS, and Moshé, SL. Getting rid of the catastrophe: frontier research in infantile spasms. Epilepsy & Seizure, J. Japan Epilepsy Soc. 6:19-29 (2013).

Wilcox, KS, Dixon-Salazar, T, Sills, GJ, Ben-Menachem, E, White, HS, Porter, RJ, Dichter, MA, Moshé, SL, Noebels, JL, Privitera, MD, Rogawski, MA. Issues related to development of new antiseizure treatments. Epilepsia 54:24-34 (2013).

Engel, J, Pitkãnen, A, Loeb, JA, Dudek, E, Bertram EH, Cole, AJ, Moshé, SL, Wiebe, S, Fureman, BE, Jensen, FE, Mody, I, Nehlig, A, Vezzani, A. Epilepsy Biomakers. Epilepsia 54:61-69 (2013)

Hesdorffer, DC, Shinnar, S., Lewis, DV, Nordli, DR, Pellock, JM, Moshé, SL, Shinnar, RC, Litherland, C., Bagiella, E., et al. Risk factors for febrile epilepticus: a case-control study.

J. Pediatrics  163:1147-51 (2013).

Lado, F, Rubboli, G, Capovilla, G, Avanzini, G, Moshé, SL. Pathophysiology of Epileptic Encephalopathies. Epilepsia 54:6-13 (2013).

Capovilla, G., Moshé, SL, Wolf, P, Avanzini G. Epileptic encephalopathy as models of system epilepsy. Epilepsia 54:34-37 (2013).

Seinfeld S, Shinnar S, Sun S, Hesdorffer DC, Deng X, Shinnar RC, O'Hara K, Nordli DR Jr, Frank LM, Gallentine W, Moshé SL, Pellock JM; FEBSTAT study team. Emergency management of febrile status epilepticus: Results of the FEBSTAT study. Epilepsia. 55(3):388-95 (2014).

Lewis, DV, Shinnar, S, Hesdorffer, DC, Bagiella, E, Bello, JA, Chan, S, Moshé, SL et al. Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT Study. Annals Neurol. 75:178-85 (2014).

Overby PJ, Beal JC, Yozawitz EG, Moshé, SL. Introduction of a Pediatric Hospitalist Service with Continuous Electroencephalography Monitoring at a Children’s Hospital. Neurohospitalist 4:74-79 (2014).

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. A practical clinical definition of epilepsy. Epilepsia 55:475-82 (2014).

 

More Information About Dr. Solomon Moshe

Developmental Epilepsy Laboratory

Clinical Programs in Child Neurology and Neurophysiology at Montefiore Medical Center

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 316
Bronx, NY 10461

Tel: 718.430.2447
solomon.moshe@einstein.yu.edu

 
Pubmed Search
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Media Coverage

The Washington Post interviews Dr. Solomon Moshé about the case of a girl with a rare form of epilepsy that causes uncontrolled bouts of laughter.

WebMD interviews Dr. Solomon Moshé about a new study that found treatment-resistant epilepsy is linked to autism.

More media coverage