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Faculty Profile

Solomon L. Moshe, M.D.

Dr. Solomon L. Moshe

Professor, The Saul R. Korey Department of Neurology

Professor, Department of Pediatrics

Professor, Dominick P. Purpura Department of Neuroscience

Charles Frost Chair in Neurosurgery and Neurology

Director, Division of Pediatric Neurology, The Saul R. Korey Department of Neurology

Director, Division of Neurology, Department of Pediatrics

Director, Clinical Neurophysiology, The Saul R. Korey Department of Neurology

 

Professional Interests

Since 1979, Dr. Moshé’s research has focused on translational approaches to understand the mechanisms underlying the development of epilepsy and its consequences in infants and children. His laboratory has developed and patented an animal model that replicates human infantile spasms. In collaboration with Dr Aristea Galanopoulou, this model is being used to identify novel treatments of this devastating condition. His work has identified an endogenous brain circuit that can control the expression of seizures as a function of age and gender. In addition to his laboratory research, he is actively involved in several large, multi-center studies examining the outcomes of prolonged, febrile seizures (seizures occurring with fever) and absence epilepsy to identify predictive biomarkers of the course and response to treatment. In more than 30 years, Dr. Moshé has mentored numerous scientists and clinicians from around the world in clinical epilepsy and basic science epilepsy-related research.

 Dr. Moshé is active in numerous professional societies and elected President of the American Epilepsy Society, the American Clinical Neurophysiology Society, the Eastern Association of Electroencephalographers, and past President of The International League against Epilepsy. He is an elected member of the American Neurological Association and the American Pediatric Society

 

Selected Publications

Akman O, Moshe SL, Galanopoulou AS. Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to Phenobarbital. CNS Neurosci. & Therapeutics 21:181-192 (2015).

Moshé, SL, Perucca, E, Ryvlin, P, Tomson Torbjõrn. Epilepsy: new advances. Lancet 385:884-898 (2015).

Jette N, Berghi E, Hesdorffer DC, Moshe SL, Zuberi S, Medina M, Bergen D. ICD coding for epilepsy: Past, present and future – A report by the International League Against Epilepsy Task Force on ICD codes in epilepsy. Epilepsia 56:348-355 (2015).

Chudomel O, Hasson H, Bojar M, Moshe SL, Galanopoulou AS. Age and sex-related characteristics from tonic GABA currents in the rat substantia nigra pars reticulata. Neurochemical Res. 40:747-57 ( 2015) 

Moshé, SL, Cross. KJ. De Bellescize, J, de Vries, L, Nordli, D, Vigevano, F. (eds). Seizures and Syndromes of onset in the Two First Years of Life. In: Progress in Epileptic Disorders . John Libbey Eurotext , publ., vol. 13 (2015).

Seinfeld S, Shinnar S, Sun S, Hesdorffer DC, Deng X, Shinnar RC, O'Hara K, Nordli DR Jr, Frank LM, Gallentine W, Moshé SL, Pellock JM; FEBSTAT study team. Emergency management of febrile status epilepticus: Results of the FEBSTAT study. Epilepsia. 55(3):388-95 (2014).

Lewis, DV, Shinnar, S, Hesdorffer, DC, Bagiella, E, Bello, JA, Chan, S, Moshé, SL et al. Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT Study. Annals Neurol. 75:178-85 (2014).

Overby PJ, Beal JC, Yozawitz EG, Moshé, SL. Introduction of a Pediatric Hospitalist Service with Continuous Electroencephalography Monitoring at a Children’s Hospital. Neurohospitalist 4:74-79 (2014).

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. A practical clinical definition of epilepsy. Epilepsia 55:475-82 (2014).

Simonato, M, Brooks-Kayal, AR, Engel J, Galanopoulou AS, Jensen FE, Moshe SL, O’Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of epilepsy therapy development in animal models. Lancet Neurol. 13:949-60 (2014)

Akman, O, Moshé, SL, Galanopoulou, AS. Sex-specific consequences of early life seizures. Neurobiol. Dis. 72:153-166 (2014)

Giorgi, FS, Galanopoulou, AS, Moshé, SL. Sex dimorphism in seizure-controlling networks. Neurobiol. Dis. 72:144-152 (2014).

Ramesh AK, Hagler S, Beal JC, Moshé SL. Pearls & Oy-sters: CSF analysis and the therapeutic paradox” in tuberculous meningitis. Neurology  83:e145-6 (2014)

Vinayan KP, Moshé, SL. Neonatal Seizures and Epilepsies. International Journal of Epilepsy. 1:75-83 (2014).

Galanopoulou, AS, Moshé, SL. Neuronal Network Mechanisms-Sex and Development.
In: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. Faingold, C. & Blumenfeld, H. eds., Chapt. 11, pgs 145-153 ,  Elsevier, publ. (2014).

Galanopoulou, AS, Moshé, SL. Epilepsy: Experimental Models. In: Encyclopedia of the Neurological Sciences. Aminoff MJ, and Daroff RB (eds), 2nd edition, vol. 2, ppg 112-117, Oxford Academic Press (2014).

Sanmaneechai, O, Sogawa, Y, Silver, W, Ballaban-Gil, K, Moshé, S, Shinnar, S. Treatment outcome of West Syndrome in infants with Down syndrome. Ped. Neurol.48:42-47 (2013),

Sanmaneechai, O, Song, JL, Nevadunsky, N, Moshé, S, Overby, PJ. Anti-N-metyl-D-aspartate encephalitis with ovarian cystadenofibroma. Ped. Neurol. 48:232-235 (2013).

Gygax, M.J. and Moshé, SL. Animal models of early life seizures and epilepsies. Neurology Asia  18:5-7 (2013).

Dlugos, D., Shinnar, S., Cnaan, A., Hu, F., Moshé, S., Mizrahi, E., Masur, D., Sogawa, Y., Levine, C., Hirtz, D., Clark, P., Adamson, P., Glauser, T. for the Childhood Absence Epilepsy Study Team. Pre-treatment EEG in newly diagnosed childhood absence epilepsy: Associations with neuropsychlogical status and initial treatment outcome. Neurology 81:150-156 (2013)

Blumcke, I., Thom, M., Aronica, E., Armstrong, D.D., Bartolomei, F., Bernasconi, A., Bien, C.G., Cendes, F., Coras, R., Cross, H., Jacques, T.S., Kahane, P., Mathern, G.W., Miyata, H., Moshé, S.L., Oz, B., Ozkara, C., Perucca, E., Sisodiya, S., Wiebe, S., Spreafico, R. International Consensus Classification of Hippocampal Sclerosis in Temporal Lobe Epilepsy: A Task Force Report from the ILAE Commission on Diagnostic Methods. Epilepsia 54:1315-29 (2013).

Moshé, SL, and Perucca, E. Epileptic Disorders to become the educational journal of ILAE. Epileptic Disorders 15:99 (2013).

Ono, T, Galanopoulou, AS, and Moshé, SL. Getting rid of the catastrophe: frontier research in infantile spasms. Epilepsy & Seizure, J. Japan Epilepsy Soc. 6:19-29 (2013).

Wilcox, KS, Dixon-Salazar, T, Sills, GJ, Ben-Menachem, E, White, HS, Porter, RJ, Dichter, MA, Moshé, SL, Noebels, JL, Privitera, MD, Rogawski, MA. Issues related to development of new antiseizure treatments. Epilepsia 54:24-34 (2013).

Engel, J, Pitkãnen, A, Loeb, JA, Dudek, E, Bertram EH, Cole, AJ, Moshé, SL, Wiebe, S, Fureman, BE, Jensen, FE, Mody, I, Nehlig, A, Vezzani, A. Epilepsy Biomakers. Epilepsia 54:61-69 (2013)

Hesdorffer, DC, Shinnar, S., Lewis, DV, Nordli, DR, Pellock, JM, Moshé, SL, Shinnar, RC, Litherland, C., Bagiella, E., et al. Risk factors for febrile epilepticus: a case-control study. J. Pediatrics  163:1147-51 (2013).

 Lado, F, Rubboli, G, Capovilla, G, Avanzini, G, Moshé, SL. Pathophysiology of Epileptic Encephalopathies. Epilepsia 54:6-13 (2013).

Capovilla, G., Moshé, SL, Wolf, P, Avanzini G. Epileptic encephalopathy as models of system epilepsy. Epilepsia 54:34-37 (2013).

 

More Information About Dr. Solomon Moshe

Developmental Epilepsy Laboratory

Clinical Programs in Child Neurology and Neurophysiology at Montefiore Medical Center

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 316
Bronx, NY 10461

Tel: 718.430.2447
solomon.moshe@einstein.yu.edu

 
Pubmed Search
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Media Coverage

The Washington Post interviews Dr. Solomon Moshé about the case of a girl with a rare form of epilepsy that causes uncontrolled bouts of laughter.

WebMD interviews Dr. Solomon Moshé about a new study that found treatment-resistant epilepsy is linked to autism.

More media coverage