Faculty Profile

Dr. William R. Jacobs, Jr., Ph.D.

William R. Jacobs, Jr., Ph.D.

Professor, Department of Microbiology & Immunology

Professor, Department of Genetics

Leo and Julia Forchheimer Chair in Microbiology & Immunology

Areas of Research: Mycobacterium tuberculosis genetics; mycobacteriophages; extensively drug resistant tuberculosis (XDR-TB), mechanishms of drug tolerance; tuberculosis vaccines; mechanism of isoniazid action.

Professional Interests

The current research intresests of my lab incldue 1) generating complete sets of precise null barcoded deletion mutants of Mycobcaterium tuberculosis to screen for virulence and drug persistence in mouse and non-human primate models, 2) use of a novel recombinant herpes vector to make novel influenza and Tuberculosis vaccines, and 3) deveop new luciferase reporter phage point of care diagnostics.

Selected Publications

  1. Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR Jr. (2019) Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. Microbiol Spectr. PMID: 31172908
  2. Porcelli, S.S, Jacobs WR Jr. (2019). Eacting Edward Jenner’s Revenge: The quest for a new tuberculosis vaccine. Sci Trasl Med. PMID: 31043569
  3. Vilchèze C, Jacobs WR Jr. (2019). The Isonizid Paradigm of Killing, Resistance, and Persistence in Mycobcaterium Tuberculosis. J Mol Biol. PMID: 30797860
  4. O’Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, D’Olivera T, Mathema B, Jacobs WR, Pym A. (2019). Early Detection of emergent drug resistant tuberculosis (XDR-TB) by flow cytometry-based phenotyping and whole genome sequencing. Antimicrob Agents Chemother. PMCID: PMC6437479
  5. Shen L., Frencher J., Huang D., Wang W., Yang E., Chen C.Y., Zhang Z., Wang R., Qaqish A., Larsen M.H., Shen H., Porcelli S.A., Jacobs W.R., Jr., Chen Z.W. (2019). Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates. Proc Natl Acad Sci U.S.A. 116 (13): 6371-6378. PMID: 30850538
  6. Johndrow CT, Goldberg MF, Johnson AJ, Ng TW, Kunnath-Velayudhan S, Lauvau G, Kaplan DH, Gossel GH, Kadolsky UD, Yates AJ, Chan J, Jacobs WR Jr, Porcelli SA. (2018). Suppresion of Th1 Priming by TLR2 Agonists during Cutaneous Immunization is Mediated by Recruited CCR2+ Monocytes. J Immunol. 201(12):3604-3616. PMID: 30455402
  7. Bhatt K, Machado H, Osório NS, Sousa J, Cardoso F, Magalhães C, Chen B, Chen M, Kim J, Singh A, Ferreira CM, Castro AG, Torrado E, Jacobs WR Jr, Bhatt A, Saraiva M. (2018). A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis. mSphere. 3(5). PMCID: PMC6211224
  8. Tiwari S, vanTonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR Jr. (2018). Arginine-deprived-induced ozidative damage sterilizes Mycobacterium tuberculosis. PNAS. 115(39):9779-9784. PMCID: PMC6166831
  9. Kennedy SC, Johnson AJ, Bharrham S, Linderstam Arlehamn CS, XU J, Garforth SJ, Chan J, Jacobs WR Jr, Settle A, Almo SC, Porcelli SA. (2018). Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells that Enhance Protective Immunity in Tuberculosis. Infection and Immunity. 86(9). PMCID: PMC6105890
  10. Vilchèze C, Copelan J, Keiser, Weisbrod T, Washington J, Jain P, Malek A, Weinrick B, Jacobs WR Jr. (2018). Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxothrophy. MBio. 9(3). PMCID: PMC5974470
  11. Harbut MB, Yang B, Liu R, Yano T, Vilchèze C, Cheng B, Lockner J, Guo H, Yu C, Franzblau SG, Petrassi HM, Jacobs WR Jr., Rubin H, Chatterjee AK, Wang F. (2018). Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity. Angew Chem Int Ed Engl. 57(13):3478-3482. PMCID: PMC6066186
  12. Vilchèze C, Weinrick B, Leung LW, Jacobs WR Jr. (2018). Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence. PNAS. 115(7):1599-1604. PMCID: PMC5816213
  13. Vilchèze C, Kim J, Jacobs WR Jr. (2018). Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice. Antimicrob Agents Chemother. PMCID: PMC5826150
  14. Burn, C., Ramsey, N., Garforth, S.J., Almo, S., Jacobs, W.R., Jr. and Herold, B.C. (2018). An HSV-2 single-cycle candidate vaccine deleted in glycoprotein D, DeltagD-2, protects male mice from lethal skin challenge with clinical isolates of HSV-1 and HSV-2. J Infect Dis. PMCID: PMC5853290
  15. Retamal-Diaz, A., Weiss, K.A., Tognarelli, E.I., Freire, M., Bueno, S.M., Herold, B.C., Jacobs, W.R., Jr. and Gonzalez, P.A. (2017). US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation. Front Immunol. (8)1523. PMCID: PMC5686121

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More Information About Dr. William Jacobs, Jr.

William R. Jacobs Labortory

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Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue , Room 577
Bronx, NY 10461

Tel: 718.678.1075
Fax: 718.678.1085

Research Information

In the News

The Scientist quotes Dr. William Jacobs Jr. on the development of tuberculosis infections in humans on immune-boosting cancer treatments.

Science News interviews Dr. Betsy Herold about her new research with Dr. Bill Jacobs on an experimental herpes vaccine.

More media coverage