Professor, Department of Pathology
Chair, Department of Pathology
We have developed a multidisciplinary group including surgery, oncology, pathology, molecular biology, protein chemistry, systems biology, epidemiology and biostatistics to study Head and Neck Squamous Cell Carcinoma (HNSCC) (www.aecom.yu.edu/headandneck/). Our studies employ cutting edge genomic and proteomic technologies to elucidate molecular mechanism regulating tumor behavior. Studies on primary human cancer and in model systems have identified candidate signatures that will be tested for use in optimizing initial treatment selection for patients with HNSCC. Our goals are:
• To develop new diagnostics that will identify optimal treatments at initial diagnosis.>
• To assess early genetic changes in smokers to identify individuals at greatest risk for developing cancer and to develop effective interventions.
• To identify potential new targets for drug development.
Sudha R, Kawachi N, Du P, Nieves E, Belbin TJ, Schlecht NF, Smith RV, Negassa A, Angeletti RH, Prystowsky MB (2007) Global proteomic analysis distinguishes differences in head and neck squamous cell carcinoma. Laboratory Investigation 87:755-766.
Loudig O, Milova E, Brandwein-Gensler M, Massimi A, Belbin TJ, Childs G, Singer RH, Rohan T, Prystowsky MB (2007) Molecular restoration of archived transcriptional profiles by complementary-template reverse-transcription (CT-RT). Nucleic Acid Research 35:pe94.
Schlecht, N.F., Burk, R.D., Adrien, L., Dunne, A., Kawachi, N., Sarta, C., Chen, Q., Brandwein-Gensler, M., Prystowsky, M.B., Childs, G., Smith, R.V. and Belbin, T.J. (2007). Gene expression profiles in HPV infected head and neck cancer. Journal of Pathology. Nov; 213(3):283-93.
Belbin TJ, Schlecht NF, Smith RV, Adrien LR, Kawachi N, Brandwein-Gensler M, Bergman A, Chen Q, Childs G, Prystowsky MB. (2008) Site-specific molecular signatures predict aggressive disease in HNSCC. Head and Neck Pathology 2(4):243-256.
Childs G, Fazzari M, Kung G, Kawachi N, Brandwein-Gensler M, McLemore M, Chen Q, Burk RD, Smith RV, Prystowsky MB, Belbin TJ. Schlecht NF (2009) Low level expression of microRNA's let7-d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. Amer J Pathol 174(3):736-745.
Prystowsky MB, Adomako A, Smith RV, Kawachi N, McKimpson W, Atadja P, Chen Q, Schlecht NF, Parish JL, Childs G, Belbin TJ (2009) The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines. Journal of Pathology, 218 (4):467-477.
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Belfer Building, Room 713
Bronx, NY 10461