Associate Professor, Department of Physiology & Biophysics
In Vivo Imaging of Animal Models of Human Disease
We use multiple modality imaging technologies (MRI, microPET, microSPECT, and microCT) to study diseases in animal models (mostly mice) of human diseases. Positron emission tomography (PET) is a nuclear medicine imaging technique that produces images of functional processes in the body. The PET scanner detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), typically 18F-Fluorodeoxyglucose (FDG), which is injected into the animal. Areas with high glucose (FDG) uptake appear bright. Single-photon emission computed tomography (SPECT) is another nuclear medicine imaging technique that uses gamma rays produced by an injected radioisotope, for example Tc-99m. Micro computer tomography (CT) uses X-rays to create high resolution anatomic images that can be co-registered with the PET and SPECT images. CT is excellent for imaging bone. Soft tissue imaging is accomplished with high resolution magnetic resonance imaging (MRI). Inveon trimodal PET/SPECT/CT and MRI scanners are available in the Gruss Magnetic Resonance Research Center (MRRC).
Specific Areas of Focus:
MicroPET/CT/SPECT imaging of mouse and rat models of diabetes, obesity, heart disease, cancer, and infectious diseases
Development and application of multimodality microPET-MRI studies of mice and rats
1. Mesenchymal bone marrow cell therapy in a mouse model of chagas disease. Where do the cells go? Jasmin, Jelicks LA, Koba W, Tanowitz HB, Mendez-Otero R, Campos de Carvalho AC, Spray DC. PLoS Negl Trop Dis. 2012;6(12):e1971.
2. Labeling stem cells with superparamagnetic iron oxide nanoparticles: analysis of the labeling efficacy by microscopy and magnetic resonance imaging. Jasmin, Torres AL, Jelicks L, de Carvalho AC, Spray DC, Mendez-Otero R. Methods Mol Biol. 2012;906:239-52. http://www.springerlink.com/content/m575m5xp10488tp4/#section=1094565&page=1
3. Gender differences in adiponectin modulation of cardiac remodeling in mice deficient in endothelial nitric oxide synthase. Durand JL, Nawrocki AR, Scherer PE, Jelicks LA. J Cell Biochem. 2012 Oct;113(10):3276-87. http://onlinelibrary.wiley.com/doi/10.1002/jcb.24206/abstract
4. Would selenium supplementation aid in therapy for Chagas disease? Jelicks LA, de Souza AP, Araújo-Jorge TC, Tanowitz HB. Trends Parasitol. 2011 Mar;27(3):102-5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049818/
More Information About Dr. Linda Jelicks
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
MRRC, Room 301
Bronx, NY 10461