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Faculty Profile

Linda A. Jelicks, Ph.D.

Dr. Linda A. Jelicks
 

Professional Interests

In Vivo Imaging of Animal Models of Human Disease

We use multiple modality imaging technologies (MRI, microPET, microSPECT, and microCT) to study diseases in animal models (mostly mice) of human diseases. Positron emission tomography (PET) is a nuclear medicine imaging technique that produces images of functional processes in the body. The PET scanner detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), typically 18F-Fluorodeoxyglucose (FDG), which is injected into the animal. Areas with high glucose (FDG) uptake appear bright. Single-photon emission computed tomography (SPECT) is another nuclear medicine imaging technique that uses gamma rays produced by an injected radioisotope, for example Tc-99m. Micro computer tomography (CT) uses X-rays to create high resolution anatomic images that can be co-registered with the PET and SPECT images. CT is excellent for imaging bone.  Soft tissue imaging is accomplished with high resolution magnetic resonance imaging (MRI).  Inveon trimodal PET/SPECT/CT and MRI scanners are available in the Gruss Magnetic Resonance Research Center (MRRC).

Specific Areas of Focus:

MicroPET/CT/SPECT imaging of mouse and rat models of diabetes, obesity, heart disease, cancer, and infectious diseases

Development and application of multimodality microPET-MRI studies of mice and rats

 

 

Selected Publications

Recent Publications

1. Mangiferin Stimulates Carbohydrate Oxidation and Protects against High Fat Diet Induced Metabolic Disorders. Apontes P, Liu Z, Su K, Benard O, Youn DY, Li X, Li W, Mirza RH, Bastie CC, Jelicks LA, Pessin JE, Muzumdar RH, Sauve AA, Chi Y. Diabetes. 2014 May 21. pii: DB_140006. [Epub ahead of print] PMID: 24848064

2. Small-animal research imaging devices. Fine EJ, Herbst L, Jelicks LA, Koba W, Theele D. Semin Nucl Med. 2014 Jan;44(1):57-65. PMID: 24314046

3. Baylisascaris larva migrans. Kazacos KR, Jelicks LA, Tanowitz HB. Handb Clin Neurol. 2013;114:251-62. Review. PMID: 23829916

4. Mesenchymal bone marrow cell therapy in a mouse model of chagas disease. Where do the cells go? Jasmin, Jelicks LA, Koba W, Tanowitz HB, Mendez-Otero R, Campos de Carvalho AC, Spray DC. PLoS Negl Trop Dis. 2012;6(12):e1971. PMID: 23272265

5.Small animal imaging of human disease: from bench to bedside and back. Jelicks LA, Tanowitz HB, Albanese C. Am J Pathol. 2013 Feb;182(2):294-5. PMID: 23260774

6. MicroPET/SPECT/CT imaging of small animal models of disease. Koba W, Jelicks LA, Fine EJ. Am J Pathol. 2013 Feb;182(2):319-24. Review. PMID: 23219729

7. Imaging of small-animal models of infectious diseases. Jelicks LA, Lisanti MP, Machado FS, Weiss LM, Tanowitz HB, Desruisseaux MS. Am J Pathol. 2013 Feb;182(2):296-304. Review. PMID: 23201133

8. Labeling stem cells with superparamagnetic iron oxide nanoparticles: analysis of the labeling efficacy  by microscopy and magnetic resonance imaging. Jasmin, Torres AL, Jelicks L, de Carvalho AC, Spray DC, Mendez-Otero R. Methods Mol Biol. 2012;906:239-52. PMID: 22791437

9. Gender differences in adiponectin modulation of cardiac remodeling in mice deficient in endothelial nitric oxide synthase. Durand JL, Nawrocki AR, Scherer PE, Jelicks LA. J Cell Biochem. 2012 Oct;113(10):3276-87. PMID: 22644792

10. Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Nagajyothi F, Machado FS,  Burleigh BA, Jelicks LA, Scherer PE, Mukherjee S, Lisanti MP, Weiss LM, Garg NJ, Tanowitz HB. Cell Microbiol. 2012 May;14(5):634-43. Review. PMID: 22309180

 

Research Images

Research Image 1
Research Image 2

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More Information About Dr. Linda Jelicks

PET/SPECT/CT Facility Wiki Page

MicroPET Facilty

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
MRRC, Room 301
Bronx, NY 10461

Tel: 718.430.2722
Fax: 718.430.8819
linda.jelicks@einstein.yu.edu

 
Pubmed Search
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