Professor, Department of Genetics
Professor, Department of Medicine (Hematology)
Professor, Department of Pediatrics
Faculty Scholar for Epigenomics, Department of Genetics
Our research is based on understanding models of genetic susceptibility to human disease, especially those affecting children.
Our main focus has been the study of the epigenome, as a regulator of transcriptional activity that can mediate memory of prior events, whether developmental cues or environmental perturbations.
We study the normal physiology of the epigenome in mammalian cells, and perform epigenome-wide association studies of human diseases.
The research is facilitated by Einstein's Center for Epigenomics, its Epigenomics Shared Facility and the Computational Epigenomics Group, where the development of the Wasp System software cyberecosystem is nurtured.
Our basic research involves the targeting mechanisms of DNA methylation, the role of non-canonical nucleic acid structures and the heritability of chromatin states. Our human disease research involves autism spectrum disorder, oncogenic viruses, and intrauterine effects on adult disease susceptibility.
We have been guided by our epigenomics studies to consider the broader possibility that mosaicism for cellular events is a much more common cause of human disease phenotypes than currently appreciated. We are therefore expanding our research interests to encompass genetic mosaicism, with an interest in isolated congential malformations and covert chromosomal aneuploidy.
Ulahannan N, Greally JM
Genome-wide assays that identify and quantify modified cytosines in human disease studies
Epigenetics & Chromatin 2015, 8: 5. doi:10.1186/1756-8935-8-5
Ramos M-P, Wijetunga NA, McLellan AS, Suzuki M, Greally JM
DNA demethylation by 5-aza-2’-deoxycytidine is imprinted, targeted to euchromatin and has limited transcriptional consequences.
Epigenetics & Chromatin 2015 Mar 17;8:11. doi:10.1186/s13072-015-0004-x. eCollection 2015. PubMed PMID: 25806086; PubMed Central PMCID: PMC4372267
Li Q, Suzuki M, Wendt J, Patterson N, Eichten SR, Hermanson PJ, Green D, Jeddeloh J, Richmond T, Rosenbaum H, Burgess D, Springer NM, Greally JM
Post-conversion targeted capture of modified cytosines in mammalian and plant genomes.
Nucleic Acids Research 2015 Mar 26. pii: gkv244. [Epub ahead of print] PubMed PMID: 25813045.
The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences.
Wijetunga NA, Delahaye F, Zhao YM, Golden A, Mar JC, Einstein FH, Greally JM.
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The New York Times interviews Dr. John Greally about a new study that suggests a father’s experiences may influence the biology of his offspring.
The New York Times features Dr. John Greally and the artist who works with Einstein’s genetic researchers to help visualize “big data.”