Faculty Profile

Dr. Norman Todd Ilowite, M.D.

Norman Todd Ilowite, M.D.

Professor Emeritus, Department of Pediatrics (Pediatric Rheumatology)

Professional Interests

juvenile rheumatoid arthritis, systemic lupus erythematosus in children and adolescents, juvenile dermatomyositis,systemic sclerosis in children, localized scleroderma, vasculitis in children, Lyme arthritis in children.

Selected Publications

1. Ilowite NT, Wedgwood RJ, Rose LM, Clark EA, Lindgren CG, Ochs HD: Impaired in vivo and in vitro antibody responses to bacteriophage ǾXl74 in juvenile rheumatoid arthritis. J Rheumatol 14:957-963, 1987.


2. Lightman HI, Pochazvesky R, Ilowite NT: Thermography in childhood RSD. J Pediatr 111:551-5,1987.


3. Ilowite NT, Samuel P, Ginzler E, Jacobson MS: Dyslipoproteinemia in pediatric systemic lupus erythematosus. Arthritis Rheum 31:859-863, 1988


4. Ilowite NT, Wedgwood JF, Valacer D, Bonagura VR: Expression of the major IgM rheumatoid factor cross-reactive idiotype precedes classic human IgG binding activity in a polyarticular juvenile rheumatoid arthritis patient. J Rheumatol 15:1789-1792, 1988.


5. Ilowite NT, Wedgwood JF, Bonagura VR: Expression of the major rheumatoid factor cross-reactive idiotype in juvenile rheumatoid arthritis. Arthritis Rheum 32:265-270, 1989.


6. Ilowite NT, Samuels P, Beselar L, Jacobson M: Dyslipoproteinemia JRA. J Pediatr 114:823-826, 1989.


7. Jacobson M, Trachtman H, Samuels P, Feldman J, Ilowite NT: Dyslipoproteinemia in the NZB/NZW murine SLE model: effect of a Menhaden oil enriched diet. Atherosclerosis 79:205-211, 1989.


8. Valacer DJ, O'Reilly ME, Ilowite NT, Bonagura VR: Identification of anti-idiotypic antibodies in the sera of rye grass allergic and non-allergic individuals. J Allergy Clin Immunol 88:349-55,1991.


9. Ilowite NT, Wedgwood JF, Moore TL, Ramakrishnan T, Bonagura VR: Hidden rheumatoid factor and rheumatoid factor cross reactive idiotype expression in juvenile rheumatoid arthritis. Scand J Immunol 34:453-460,1991.


10. Walco GA, Varni JW, Ilowite NT: Cognitive-behavioral pain management in children with juvenile rheumatoid arthritis. Pediatrics 89:1075-1079,1992.


11. Ilowite NT, Walco GA, Pochazchevsky R: Pain assessment in juvenile rheumatoid arthritis: the relationship between pain intensity and degree of joint inflammation. Ann Rheum Dis 51:343-346,1992.


12. Walco GA, Ilowite NT: Cognitive-behavioral intervention for juvenile primary fibromyalgia syndrome. J Rheumatol 19:1617-1619,1992.


13. Sood SK, Rubin LG, LeBlanc ME, Ilowite NT: Positive Lyme disease serology in juvenile rheumatoid arthritis in a Lyme disease endemic area: analysis by immunoblot. J Rheumatol 20:739-741,1993.


14. Schuval SJ, Frances A, Valderrama E, Bonagura VR, Ilowite NT: Panniculitis and fever in childhood. J Pediatr 122:372-378,1993.


15. Ilowite NT, Wedgwood JF, Ramakrishnan TK, Bonagura VR: Rheumatoid factor-related molecules in juvenile rheumatoid arthritis: the role of the CD5+ B cell. Clin Immunol Immunopathol 67:S74-82,1993.


16. Schuval SJ, Bonagura VR, Ilowite NT: Rheumatologic manifestations of human immunodeficiency virus infection in children. J Rheumatol 20:1578-1582, 1993.


17. Levine JJ, Sherry DD, Strickland DK, Ilowite NT: Intra-articular alpha 2 macroglobulin complexes in juvenile rheumatoid arthritis. Pediatr Res 34:204-207,1993.


18. Levine JJ, Ilowite NT: Scleroderma-like esophogeal disease in children breast fed from mothers with breast implants. JAMA 271:213-216,1994.


19. Kwong T, Valderrama E, Paley C, Ilowite NT: Systemic necrotizing vasculitis associatd with childhood sarcoidosis. Sem Arth Rheum 23:388-395,1994.


20. Kwong T, Leonides J, Ilowite NT: Asymptomatic superior vena cava obstruction and pulmonary embolism in an adolescent with SLE and antiphospholipid antibodies. Clin Exp Rheum 12:215-217,1994.


21. Sood SK, Zemel LS, Ilowite NT: Criteria for positive immunoblot in pediatric Lyme arthritis. J Rheumatol 22:758-61,1995.


22. Ilowite NT, Copperman N, Leicht T, Kwong T, Jacobson MS: Effects of dietary modification and fish oil
supplementation in dyslipoproteinemia in pediatric systemic lupus erythematous. J Rheumatol 22:1347-51,1995.


23. Levine JJ, Lin HC, Rowley M, Cook A, Teuber SS, Ilowite NT: Autoantibody expression in children born to mothers with silicone breast implants: lack of association with clinical symptoms. J Pediatr 97:243-245,1996.


24. Levine JJ, Ilowite NT, Pettei MJ, Trachtman H: Increased NO3- + NO2- and neopterin excretion in children breast fed by mothers with silicone breast implants: evidence for macrophage activation. J Rheumatol 23:1083-1087, 1996.


25. Gottlieb BS, Miller LC, Ilowite NT: Methotrexate treatment of Wegener’s Granulomatosis in children. J Pediatr 129:604-607,1996.


26. Jain VK, Hilton E, Maytal J, Gerber MA, Dorante G, Ilowite NT, Sood SK: Immunoglobulin M immunoblot for diag-nosis of Borrelia burgdorferi infection in patients with acute facial palsy. J Clin Microbiology 34:2033-2035, 1996.


27.Gottlieb BS, Keenan GF, Lu T, Ilowite NT: Discontinuation of methotrexate treatment in juvenile rheumatoid arthritis. Pediatrics 100:994-997,1997.


28. Sandborg C, Wallace C, Ilowite NT et al: Position statement of the American College of Rheumatology regarding referral of children and adolescents to pediatric rheumatologists. Arthritis Care and Research 12:48-51,1999.


29. Cassidy JT, Athreya BH, Ilowite NT et al: The future status of pediatric rheumatology in the United States: strategic planning for the year 2000. Arthritis Rheum 43:239-242, 2000.


30. Degotardi P, Revenson TA, Ilowite NT: Family coping strategies, treatment compliance and psychosocial adjustment in adolescents with JRA. Arthritis Care and Research 12:314-324,1999.


31. Lovell DJ, Giannini EH, Reiff A, Cawkwell GD, Silverman ED, Nocton JJ, Stein LD, Gedalia A, Ilowite NT, Wallace CA, Whitmore J, Finck BK. Etanercept in children with polyarticular juvenile rheumatoid arthritis. N Engl J Med. 2000 Mar 16;342(11):763 9.


32. Ilowite NT. Current treatment of Juvenile Rheumatoid Arthritis. Pediatrics 2002;109:109-115


33. Milojevic D, Ilowite NT. Treatment of rheumatic diseases in children: special considerations. Rheum Dis Clinics N Amer 2002;28:461-482


34. Eberhard A, Ilowite NT: Lipodystrophy and panniculitis. Current Opinion Rheum 2002;14:566-570


35. Weiss KA, Schiaffino KM, Ilowite N: Predictors of sibling relationship characteristics in youth with juvenile chronic arthritis. Children’s Health Care 2001;30:67-77.


36. Kodsi SR, Rubin SE, Milojevic D, Ilowite N, Gottlieb B. Time of onset of uveitis in children with juvenile rheumatoid arthritis. J AAPOS 2002 Dec;6(6):373-6


37. Lovell DJ, Giannini EH, Reiff A, Jones, OY, Schneider R, Olson JC, Gedalia A, Ilowite NT, et al: Long-term efficacy and safety of etanercept in children with polyarticular-course juvenile rheumatoid arthritis. Interim results from an ongoing multicenter, open-label, extended treatment trial. Arthritis Rheum 48;218-226:2003


38. Milojevic D, Ilowite NT: Dyslipoproteinemia and premature atherosclerosis in the pediatric rheumatic diseases. In: Atherosclerosis and Autoimmunity. Y Shoenfeld, D Harats, G Wick Eds. Elsevier Science BV, Amsterdam 2001.


39. Weiss JE, Ilowite NT: Juvenile idiopathic arthritis. In: Recent Advances in Paediatrics . Timothy J David Ed. Royal Society of Medicine Press Ltd., London, 2004.


40. Eberhard BA, Sison C, Gottlieb B, Ilowite NT. A Comparison of the intra-articular effectiveness of triamcinolone hexacetonide and triamcinolone acetonide in the treatment of children with juvenile rheumatoid arthritis. J Rheumatol 2004;31:2507-12.


41. Eberhard BA, Ilowite NT. Response of systemic onset juvenile rheumatoid arthritis to etanercept: is the glass half empty or half full? J Rheumatol 2005;32:763-4


42. Irigoyen PI, Olson J, Hom C, Ilowite NT. Treatment of systemic onset juvenile rheumatoid arthritis with anakinra. Arthritis Rheum 2004; 50:S438.(abstract)


43. Weiss JE, Ilowite NT: Juvenile idiopathic arthritis. Pediatric Clin N Am 52:413-442;200


44. Pachman LM, Lipton R, Ramsey-Goldman R, Shamiyeh E, Abbott K, Mendez EP, Dyer A, Curdy DM, Vogler L, Reed A, Zemel L, Sandbor C, Rivas-Chacon R, Hom C, Ilowite N, Gedalia A, Gitlin J, Brozy M. History of infection before the onset of juvenile dermatomyositis: results from the National Institute of Arthritis and Musculoskeletal Diseases Research Registry. Arthritis Rheum 2005;53:166-72.


45 Pachman LM, Abbott K, Sinacore JM, Amoruso I, Dyer A, Lipton R, Ilowite N, Hom C, Cawkwell G, White A, Rivas-Chacon R, Kimura Y, Ray I, Ramsey-Goldman R. Duration of illness is an important variable for untreated children with juvenile dermatomyositis. J Pediatr 148: 247-53;2006


46. Lovell DJ, Reiff A, Jones OY, Schneider R, Nocton J, Stein L, Gedalia A, Ilowite NT, Wallace CA, Whitmore JB, White B, Giannini GH. Long-term Safety and Efficacy Experience with Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis. Arthritis Rheum, 2006;54:1987-1994


47. Irigoyen P, Olson, J, Hom C, Ilowite N. Treatment of systemic onset juvenile idiopathic arthritis with anakinra. Pediatric Rheumatology Online Journal, March 2006.


48. Giannini EH, Ilowite NT, Lovell DJ, Wallace CA, Rabinovich EC, Reiff AO, Bevirt T, Chen CY, Tsuji WH. A Phase 4 registry of etanercept in children with juvenile rheumatoid arthritis. Ann Rheum Dis 2006;54 (suppl 9): S327


49. Bleesing J, Prada A, Siegel D, Villanueva J, Olson J, Ilowite N et al. The diagnostic significance of soluble CD163 and soluble IL2Rá chains in macrophage activation syndrome and untreated new onset systemic juvenile idiopathic arthritis. Arthritis Rheum 2007;56:965-71


50. Weiss JE, Sison CP, Ilowite NT, Gottlieb BS, Eberhard BA. Flares in pediatric systemic lupus Erythematosus. J Rheumatol, 2007 Jun;34(6):1341-1343.


51. Sacks J, Helmick C, Luo YH, Ilowite N, Bowyer S. Prevalence of and annual ambulatory health care visits for pediatric arthritis and other rheumatologic conditions, United States. Arthritis Rheum 2007;57:1439-1445.


52. Fall N, Barnes M, Thornton S, Luyrink L, Jennings K, Olson J, Ilowite N, Griffin T, Sherry D, Thompson S, Colbert R, Grom A. Gene expression profiling in peripheral blood in untreated new onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum 2007;56:3793-3804.


53. Seshadri R, Feldman BM, Ilowite N, Cawkwell GD, Pachman LM. The role of aggressive corticosteroid therapy in juvenile dermatomyositis: a propensity score analysis. Arthritis Care and Research, in press.

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