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Faculty Profile

Sergei Khrapunov, Ph.D.

Dr. Sergei Khrapunov

Research Professor, Department of Biochemistry

 

Professional Interests

Structure and thermodynamics of proteins and protein-DNA complexes. Chromatin structure.

 

Selected Publications

Selected publications

Khrapunov, S., Warren, C., Cheng, H. Y., Berko, E.R., Greally, J.M. & Brenowitz, M.– “Unusual Characteristics of the DNA Binding Domain of Epigenetic Regulatory Protein MeCP2 Determine Its Binding Specificity”.Biochemistry, 2014, 53, 3379−3391.

Khrapunov, S. & Brenowitz, M.– “Stability, denaturation and refolding of Mycobacterium tuberculosis MfpA, a DNA mimicking protein that confers antibiotic resistance”. Biophysical Chemistry, 2011, 159, 33-40.

Khrapunov S.– “Circular dichroism spectroscopy has intrinsic limitations for protein secondary structure analysis”.  Anal Biochem. 2009, 389, 174-176

Khrapunov S, Cheng H, Hegde S, Blanchard J, Brenowitz M. –“Solution Structure Refolding of the Mycobacterium tuberculosis Pentapeptide Repeat Protein MfpA” .  J Biol. Chem. 2008, 283, 36290-9

Khrapunov, S. and Brenowitz, M. – “Influence of the N-terminal domain and divalent cations on self association and DNA binding by the Saccharomyces cerevisiae TATA Binding Protein" - Biochemistry, 2007, 4876-4887.

Khrapunov, S., Brenowitz, M., Rice, P.A.  & Catalano, C.E. - "Binding then bending: A mechanism for wrapping DNA"[Invited commentary] - Proc.Natl.Acad.Sci.USA, 2006, 103, 19217-19218.

Blakaj, B., Kattamuri, C., Khrapunov, S., Rashmi S. Hegde, R.S., Brenowitz, M. - "Indirect Readout of DNA Sequence by Papillomavirus E2 Proteins Depends Upon Net Cation Uptake"  - J. Mol. Biol, 2006, 358, 224–240 

Khrapunov, S. and M. Brenowitz. - "Comparison of the effect of water release on the interaction of the Saccharomyces cerevisiae TATA binding protein (TBP) with "TATA Box" sequences composed of adenosine or inosine”. -Biophys J., 2004, 86, 371-383.

Khrapunov S., Pastor N. & Brenowitz M. – “Solution structural studies of the Saccharomyces cerevisiae TATA Binding Protein (TBP)” – Biochemistry, 2002, 41, 9559-9571.

Khrapunov S.N., Dragan A.I., Sivolob A.V., Zagariya A.M.-“Mechanisms of  Stabilizing Nucleosome Structure.  Study of Dissociation of Histone Octamer from DNA”.- Biochim.Biophys.Acta,1997,1351, 213-222.

Sivolob A.V., Khrapunov S.N.-“Electrostatic contribution to the bending of DNA”.-Biophysical Chemistry, 1997,67, 85-89

Sivolob A.V., Khrapunov S.N.-“Translatioal Positioning of Nucleosomes on DNA: The Role  of  Sequence-dependent  Isotropic  DNA  Bending Stiffness”.-J. Mol. Biol., 1995,247,918-931.

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 311
Bronx, NY 10461

Tel: 718.430.3180
Fax: 718.430.8565
sergei.khrapunov@einstein.yu.edu

 
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