Professor, Department of Biochemistry
Biology is a dynamic process. Among the myriad array of reversible association reactions that constitute life, small molecules bind to proteins, proteins self-associate and bind to other proteins and nucleic acids and nucleic acids fold and bind to each other in elaborate processing, signaling and regulatory cascades. What is common to these processes is the physical chemistry that underlies these interactions. For example, electrostatic interactions mediate both the binding of proteins to DNA and the folding of RNA. Proteins that mimic the electrostatic character of DNA may competitively regulate DNA binding by other proteins. Our laboratory seeks answers to questions related to the structure – function relationships that govern macromolecular function by combining quantitative analysis with innovative approaches.
Khrapunov, S., Warren, C., Cheng, H., Berko, E., Greally, J.M. & Brenowitz, M. (2014) Unusual characteristics of MBD, the DNA binding domain of epigenetic regulatory protein MeCP2, determine its binding specificity, Biochemistry, 53(21), 3379-91
Padlan, C.S., Malashkevich, V., Almo, S.C., Levy, M., Brenowitz, M. & Girvin, M.E. (2014) An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates, RNA, 20(4), 447-61
Schlatterer, J.C., Martin, J.S., Laederach, A.L. & Brenowitz, M. (2014) Mapping the kinetic barriers of a large RNA molecule’s folding landscape, PLoS One 9(2), e85041
Chen, C., Mitra, S., Jonikas, M., Martin, J., Brenowitz, M., Laederach, A. Biophys J. (2013) Understanding the role of 3-dimensional topology in determining the folding intermediates of group 1 introns, Biophys J. 104(6), 1326-37
Schlatterer, J.C., Wieder, M.S., Jones, C.D., Pollack, L. & Brenowitz, M. (2012) Pyrite footprinting of RNA, Biochem Biophys Res Commun., 425(2), 374 - 378
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 311
Bronx, NY 10461