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Faculty Profile

Herbert M. Lachman, M.D.

Dr. Herbert M. Lachman
 

Professional Interests

 

Dr. Herbert Lachman is a physician and behavioral geneticist interested in the molecular and genetic basis of schizophrenia, addiction, and bipolar disorder. His lab’s primary research projects involve the use of induced pluripotent stem (iPS) cells for modeling neuropsychiatric disorders. Patient-specific iPS cells are generated from skin fibroblasts, which are ultimately induced to differentiate into neurons. Epigenetic analysis and gene expression profiling for protein-coding genes, long non-coding RNAs and microRNAs are being carried out. The work is supported by two NIMH grants. 
Additionally, Dr. Lachman’s lab uses a technique called chromatin immunoprecipitation (ChIP) to study the regulation of genes involved in psychiatric disorders. Dr. Lachman and colleagues have analyzed a protein called beta-catenin, which is affected by lithium – one of the most important drugs used to treat bipolar disorder. The lab discovered hundreds of different genes that are regulated by beta-catenin, leading to the identification of novel genes and molecular networks involved in bipolar disorder and schizophrenia.
Dr. Lachman is board certified in Internal Medicine and has clinical responsibilities in the Einstein Division of Substance Abuse, where he is the director of the Medical Maintenance Program.
Dr. Lachman teaches human genetics to first-year medical students and graduate students, and directs a course in human genetics in the Clinical Research Training Program. He also gives seminars in psychiatric genetics to psychiatry residents and DOSA fellows. He was elected to the Leo Davidoff Society for distinguished teaching and received the 2010 Samuel M. Rosen Outstanding Teacher Award for excellence in basic science teaching.
Dr. Lachman is a member of the International Society of Psychiatric Genetics and the American Association for the Advancement of Science. He serves as an editor at the Frontiers Journal and the Open Psychiatry Journal. He has served as a reviewer for more than two dozen journals. 
Dr. Lachman received his Bachelor of Science degree in 1973 from the City University of New York system and his medical degree in 1976 from New York Medical College. After completing his internship and residency at Metropolitan Hospital in 1979, Dr. Lachman came to Einstein as a clinical hematology fellow at Montefiore Medical Center. He then completed a postdoctoral fellowship in the Division of Hematology under the supervision of Drs. Gregory Mears and Ronald Nagel. Dr. Lachman then moved to the Cell Biology department where he completed a postdoctoral fellowship under Dr. Arthur Skoultchi. He joined the Einstein faculty in 1985 as a member of the Department of Medicine, ultimately switching his primary appointment to the Department of Psychiatry and Behavioral Sciences in 1990. 

Dr. Herbert Lachman is a physician and behavioral geneticist interested in the molecular and genetic basis of schizophrenia, addiction, and bipolar disorder. His lab’s primary research projects involve the use of induced pluripotent stem cells (iPSCs) for modeling neuropsychiatric disorders. Patient-specific iPCS are generated from skin fibroblasts, which are ultimately induced to differentiate into neurons. Epigenetic analysis and gene expression profiling for protein-coding genes, long non-coding RNAs and microRNAs are being carried out. 

Additionally, Dr. Lachman’s lab uses gene knockdown approaches to study the effects of schizophrenia and bipolar disorder candidate genes, in particular those that regulate other genes (transcription factors, chromatin modifiers, for example). His lab has recently knocked down ZNF804A and A2BP1 in neural progenitor cells derived from iPSCs and is in the process of determining the molecular and genetic networks affected by these schizophrenia candidate genes, which code for a putative transcription factor and regulator of neuron-specific splicing, respectively. Dr. Lachman's lab is also carrying out whole genome sequencing in multiplex families with bipolar disorder.

Dr. Lachman is board certified in Internal Medicine and has clinical responsibilities in the Einstein Division of Substance Abuse, where he is the director of the Medical Maintenance Program. He also teaches human genetics to first-year medical students and graduate students, and directs a course in human genetics in the Clinical Research Training Program.

 

 

Selected Publications

Selected publications since 2007

Herbert M. Lachman, Cathy S.J. Fann, Michael Bartzis, Oleg V. Evgrafov, Richard N. Rosenthal, Edward V. Nunes, Christian Miner, Maria Santana, Jebediah Gaffney, Amy Riddick, Chia-Lin Hsu, James Knowles (2007) Genomewide Suggestive Linkage of Opioid Dependence to Chromosome 14q. Human Molecular Genetics 16(11):1327-1334

Herbert M. Lachman Oriana A. Petruolo Erika Pedrosa, Tomas Novak, Karen Nolan, Pavla Stopkova (2008). Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia (in press: Psychiatric Genetics 18(3):110-115.

Erika Pedrosa, Radu Stefanescu, Oriana Petruolo, Yungtai Lo, Karen Nolan, Pavla Stopkova, Herbert M. Lachman (2008). Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (Schizophrenia Research). 102 (1-3):210-219.

Rael D. Strous MD, Michael S. Ritsner MD PhD, Shmulik Adler BA, Yael Ratner MD, Rachel Maayan PhD, Moshe Kotler MD, Herbert Lachman MD, Abraham Weizman MD (2009) Improvement of Aggressive Behavior and Quality of Life Impairment Following S-Adenosyl-Methionine (SAM-e) Augmentation in Schizophrenia Eur. Neuropsychopharm. in press 19(1):14-22

Erika Pedrosa, Joseph Locker, Herbert M. Lachman (2009).Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip) Journal of Neurogenetics, 18:1-12.

Erika Pedrosa, Karen A. Nolan, Radu Stefanescu, Pnina Hershcovitz, Tomas Novak, Ilja Zukov, Pavla Stopkova (2009) Herbert M. Lachman Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in schizophrenia Neuropsychobiology 59:205-212.

Joshua T Kantrowitz, Karen Nolan, Srijan Sen, Arthur Simen, Herbert Lachman, Malcolm B Bowers (2009) Adolescent Cannabis Use, Psychosis and Catechol-O-Methyltransferase Genotype in African Americans and Caucasians. Psychiatr Q. 2009 Jul 25. [Epub ahead of print].

Erika Pedrosa, Abhishek Shah, Christopher Tenore, Michael Capogna, Catalina Villa, Herbert M. Lachman. Beta-catenin promoter ChiP-chip reveals potential schizophrenia and bipolar disorder gene network. J Neurogenet. 2010 Dec;24(4):182-93

Abhishek K. Shah, Nina M Tioleco, Karen Nolan, Joseph Locker, Katherine Groh, Catalina Villa, Tomas Novak, Pavla Stopkova, Erika Pedrosa, Herbert M. Lachman Rare NRXN1 promoter variants in patients with schizophrenia. Neuroscience Letters, 2010 475(2):80-4

Pedrosa E, Sandler V, Shah A, Carroll R, Chang C, Rockowitz S, Guo X, Zheng D, Lachman HM.Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells. J Neurogenet. 2011, 25(3):88-103

Mingyan Lin, Erika Pedrosa, Abhishek K. Shah, Anastasia Hrabovsky, Shahina Maqbool, Deyou Zheng, Herbert M. Lachman. Deep sequencing transcriptome analysis of human neurons derived from induced pluripotent stem cells identifies candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. PLoS One, 2011;6(9):e23356.

Mingyan Lin, Anastasia Hrabovsky, Erika Pedrosa, Tao Wang, Deyou Zheng, Herbert M. Lachman. Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders. PLoS One. 2012;7(8):e44017. Epub 2012 Aug 30.

 

 

 

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Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 103
Bronx, NY 10461

Tel: 718.430.2428
Fax: 718.430.8772
herb.lachman@einstein.yu.edu

 
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