Professor, Department of Medicine (Hematology)
Associate Professor, Dominick P. Purpura Department of Neuroscience
Associate Professor, Department of Genetics
Dr. Herbert Lachman is a physician and behavioral geneticist interested in the molecular and genetic basis of schizophrenia, addiction, and bipolar disorder. His lab’s primary research projects involve the use of induced pluripotent stem cells (iPSCs) for modeling neuropsychiatric disorders. Patient-specific iPCS are generated from skin fibroblasts, which are ultimately induced to differentiate into neurons. Epigenetic analysis and gene expression profiling for protein-coding genes, long non-coding RNAs and microRNAs are being carried out.
Additionally, Dr. Lachman’s lab uses gene knockdown approaches to study the effects of schizophrenia and bipolar disorder candidate genes, in particular those that regulate other genes (transcription factors, chromatin modifiers, for example). His lab has recently knocked down ZNF804A and A2BP1 in neural progenitor cells derived from iPSCs and is in the process of determining the molecular and genetic networks affected by these schizophrenia candidate genes, which code for a putative transcription factor and regulator of neuron-specific splicing, respectively. Dr. Lachman's lab is also carrying out whole genome sequencing in multiplex families with bipolar disorder.
Dr. Lachman is board certified in Internal Medicine and has clinical responsibilities in the Einstein Division of Substance Abuse, where he is the director of the Medical Maintenance Program. He also teaches human genetics to first-year medical students and graduate students, and directs a course in human genetics in the Clinical Research Training Program.
Selected publications since 2007
Herbert M. Lachman, Cathy S.J. Fann, Michael Bartzis, Oleg V. Evgrafov, Richard N. Rosenthal, Edward V. Nunes, Christian Miner, Maria Santana, Jebediah Gaffney, Amy Riddick, Chia-Lin Hsu, James Knowles (2007) Genomewide Suggestive Linkage of Opioid Dependence to Chromosome 14q. Human Molecular Genetics 16(11):1327-1334
Herbert M. Lachman Oriana A. Petruolo Erika Pedrosa, Tomas Novak, Karen Nolan, Pavla Stopkova (2008). Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia (in press: Psychiatric Genetics 18(3):110-115.
Erika Pedrosa, Radu Stefanescu, Oriana Petruolo, Yungtai Lo, Karen Nolan, Pavla Stopkova, Herbert M. Lachman (2008). Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (Schizophrenia Research). 102 (1-3):210-219.
Rael D. Strous MD, Michael S. Ritsner MD PhD, Shmulik Adler BA, Yael Ratner MD, Rachel Maayan PhD, Moshe Kotler MD, Herbert Lachman MD, Abraham Weizman MD (2009) Improvement of Aggressive Behavior and Quality of Life Impairment Following S-Adenosyl-Methionine (SAM-e) Augmentation in Schizophrenia Eur. Neuropsychopharm. in press 19(1):14-22
Erika Pedrosa, Joseph Locker, Herbert M. Lachman (2009).Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip) Journal of Neurogenetics, 18:1-12.
Erika Pedrosa, Karen A. Nolan, Radu Stefanescu, Pnina Hershcovitz, Tomas Novak, Ilja Zukov, Pavla Stopkova (2009) Herbert M. Lachman Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in schizophrenia Neuropsychobiology 59:205-212.
Joshua T Kantrowitz, Karen Nolan, Srijan Sen, Arthur Simen, Herbert Lachman, Malcolm B Bowers (2009) Adolescent Cannabis Use, Psychosis and Catechol-O-Methyltransferase Genotype in African Americans and Caucasians. Psychiatr Q. 2009 Jul 25. [Epub ahead of print].
Erika Pedrosa, Abhishek Shah, Christopher Tenore, Michael Capogna, Catalina Villa, Herbert M. Lachman. Beta-catenin promoter ChiP-chip reveals potential schizophrenia and bipolar disorder gene network. J Neurogenet. 2010 Dec;24(4):182-93
Abhishek K. Shah, Nina M Tioleco, Karen Nolan, Joseph Locker, Katherine Groh, Catalina Villa, Tomas Novak, Pavla Stopkova, Erika Pedrosa, Herbert M. Lachman Rare NRXN1 promoter variants in patients with schizophrenia. Neuroscience Letters, 2010 475(2):80-4
Pedrosa E, Sandler V, Shah A, Carroll R, Chang C, Rockowitz S, Guo X, Zheng D, Lachman HM.Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells. J Neurogenet. 2011, 25(3):88-103
Mingyan Lin, Erika Pedrosa, Abhishek K. Shah, Anastasia Hrabovsky, Shahina Maqbool, Deyou Zheng, Herbert M. Lachman. Deep sequencing transcriptome analysis of human neurons derived from induced pluripotent stem cells identifies candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. PLoS One, 2011;6(9):e23356.
Mingyan Lin, Anastasia Hrabovsky, Erika Pedrosa, Tao Wang, Deyou Zheng, Herbert M. Lachman. Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders. PLoS One. 2012;7(8):e44017. Epub 2012 Aug 30.
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