Faculty Profile

Dr. David M. Loeb, M.D.,  Ph.D.

David M. Loeb, M.D., Ph.D.

Associate Professor, Department of Pediatrics (Pediatric Hematology-Oncology)

Associate Professor, Department of Developmental & Molecular Biology

Chief, Division of Pediatric Hematology / Oncology, Department of Pediatrics

Areas of Research: Dr. Loeb has a translational research laboratory focused on the biology and treatment of bone tumor metastasis, especially the role of Wnt signaling pathways. Projects range from basic through clinical.

Professional Interests

Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis.  His laboratory developed a clinically relevant mouse model of sarcoma metastasis, and has used this model to perform preclinical testing of novel agents that can interfere with this process.  More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma migration, invasion, and metastasis.  Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA.

 

Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3.  He serves as the Coordinating Physician for an international Phase I study of an immune checkpoint inhibitor for pediatric solid tumors, and he has directed a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors.  Finally, as an offshoot of his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents, and young adults with sarcomas.

Selected Publications

Dr. Loeb's PubMed bibliography can be found here:  

https://www.ncbi.nlm.nih.gov/sites/myncbi/1fiIspwqfwUE46/bibliography/55061260/public/?sort=date&direction=ascending.

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Montefiore Medical Center
3411 Wayne Avenue , Room 910
Bronx, NY 10467

Tel: 718.920.4664
david.loeb@einstein.yu.edu

Research Information