Faculty Profile

Dr. David Q.H. Wang, M.D.,  Ph.D.

David Q.H. Wang, M.D., Ph.D.

Professor, Department of Medicine (Hepatology)

Professor, Department of Genetics

Areas of Research: Cholesterol and bile acid metabolism in the liver, bile, intestine and plasma; Cholelithiasis; Intestinal lipid absorption; Nonalcoholic fatty liver disease; Alcoholic liver disease; cholestasis.

Professional Interests

Dr. Wang has an active research interest in the molecular and genetic mechanisms of cholesterol homeostasis and the pathophysiology of cholesterol-related diseases. The long-term objectives of his research are (i) to identify gallstone (LITH) genes and investigate their genotypes and phenotypes in mice and humans, as well as elucidate the molecular, cellular, genetic and physical-chemical mechanisms of cholesterol gallstone disease at a fundamental level; (ii) to study molecular, cellular, genetic and physical-chemical factors that determine intestinal absorption efficiency of cholesterol and fatty acids; and (iii) to investigate the pathophysiology of the metabolic syndrome with a special focus on the relationship between insulin resistance and nonalcoholic fatty liver disease, and examine the pathogenesis of alcoholic liver disease and obesity, as well as explore novel approaches for the prevention and treatment of these lipid-related hepatobiliary and gastrointestinal diseases.

Selected Publications

Wang DQ, Portincasa P (Editors). Gallstones: Recent advances in epidemiology, pathogenesis, diagnosis and management. The first edition. Nova Science Publishers. New York, NY. 2017. pp. 1-676.

Wang HH, Li X, Patel SB, Wang DQ. Evidence that the ABCG5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice. Hepatology. 2016; 64: 853-864.

Wang DQ, Afdhal NH. Chapter 65. Gallstone disease. In Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, the 10th Edition. Editors by Feldman M, Friedman LS, and Brandt LJ. Elsevier Saunders. 2016; 1100-1133.

Portincasa P, Wang DQ. Chapter 89. Gallstones. In Yamada’s Textbook of Gastroenterology, 2 Volume Set, 6th Edition. Editors by Podolsky DK, Camilleri M, Fitz JG, Kalloo AN, Shanahan F, Wang TC. Wiley-Blackwell. Hoboken, NJ. 2015; pp. 1808-1834.

Lammert F, Gurusamy K, Ko CW, Miquel JF, Méndez-Sánchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ. Gallstones.Nat. Rev. Dis. Primers. 2016; 2: 16024-16040.

Wang DQ, Cohen DE. Absorption and excretion of intestinal cholesterol and other sterols. In Clinical Lipidology: A Companion to Braunwald’s Heart Disease. The 2nd Edition. Editor by Ballantyne CM. Elsevier Saunders. 2015; pp. 25-42.

de Bari O, Wang TY, Liu M, Portincasa P, Wang DQ. Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice. J. Lipid Res. 2015; 56: 1691-1700.

de Bari O, Wang HH, Portincasa P, Liu M, Wang DQ. The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice. Biochim. Biophys. Acta. 2015; 1852: 2161-2169.

Wang TY, Liu M, Portincasa P, and Wang DQ. New insights into the molecular mechanism of intestinal fatty acid absorption. Eur. J. Clin. Invest. 2013; 43: 1203-1223.

Wang DQ, Portincasa P, and Neuschwander-Tetri BA. Steatosis in the Liver. Comprehensive Physiology. 2013; 3: 1493-1532.

Wang HH, Portincasa P, Afdhal NH, Wang DQ. Lith genes and genetic analysis of cholesterol gallstone formation. Gastroenterol. Clin. North Am. 2010; 39: 185-207.

Wang HH, Portincasa P, Liu M, Tso P, Samuelson LC, Wang DQ. Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice. Biochim. Biophys. Acta. 2010; 1801: 138-146.

Wang HH, Portincasa P, Mendez-Sanchez N, Uribe M, Wang DQ. Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology. 2008; 134: 2101-2110.

Wang DQ, Lee SP. Physical-chemistry of intestinal absorption of biliary cholesterol in mice. Hepatology. 2008; 48: 177-185.

Wang DQ. Regulation of intestinal cholesterol absorption. Ann. Rev. Physiol. 2007; 69: 221-248.

Wang HH, Afdhal NH, Gendler SJ, Wang DQ. Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice. Gastroenterology. 2006; 131: 210-222.

Wang HH, Afdhal NH, Wang DQ. Overexpression of estrogen receptor α increases hepatic cholesterogenesis, leading to biliary hypersecretion in mice. J. Lipid Res. 2006; 47: 778-786.

Wang HH, Wang DQ. Reduced susceptibility to cholesterol gallstone formation in mice that do not produce apolipoprotein B48 in the intestine. Hepatology. 2005; 42: 894-904.

Wang DQ, Schmitz F, Kopin AS, Carey MC. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. J. Clin. Invest. 2004; 114: 521-528.

Wang HH, Afdhal NH, Wang DQ. Estrogen receptor α, but not β, plays a major role in 17β-estradiol-induced murine cholesterol gallstones. Gastroenterology. 2004; 127: 239-249.

Lammert F, Wang DQ, Hillebrandt S, Geier A, Fickert P, Trauner M, Matern S, Paigen B, Carey MC. Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: A model for low phospholipid-associated cholelithiasis. Hepatology. 2004; 39: 117-128.

Wang DQ, Lammert F, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: pathophysiology of biliary lipid secretion. J. Lipid Res. 1999; 40: 2066-2079.

Lammert F, Wang DQ, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes. J. Lipid Res. 1999; 40: 2080-2090.

Wang DQ, Lammert F, Cohen DE, Paigen B, Carey MC. Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis. Am. J. Physiol. 1999; 276: G751-G760.Wang DQ, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. J. Lipid Res. 1997; 38: 1395-1411.

Wang DQ, Carey MC. Complete mapping of crystallization pathways during cholesterol precipitation from model biles: influence of physical-chemical variables of pathophysiologic relevance and identification of a stable liquid crystalline state in cold, dilute and hydrophilic bile salt-containing systems. J. Lipid Res. 1996; 37: 606-630.

Khanuja B, Cheah Y-C, Hunt M, Nishina PM, Wang DQ, Chen HW, Billheimer JT, Carey MC, Paigen B. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc. Natl. Acad. Sci. USA. 1995; 92: 7729-7733.

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Research Information

In the News

Immune “Webs” May Aid the Formation of Gallstones

David Q.H. Wang, M.D., Ph.D., details the limitations of a study that claims sticky clumps of DNA and protein extruded by immune cells help gallstones form. Dr. Wang is professor of medicine and of genetics at Einstein.

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