Faculty Profile

Dr. J. Tiago Goncalves, Ph.D.

J. Tiago Goncalves, Ph.D.

Assistant Professor, Dominick P. Purpura Department of Neuroscience

Areas of Research: Adult neurogenesis, Neuronal development, Learning and Memory, Aging

Professional Interests

The dentate gyrus (DG) is one of the few regions of the mammalian brain that keeps adding new neurons through adulthood in what probably constitutes the most robust form of neuronal plasticity in the adult brain. Adult-born neurons contribute to memory formation and defects in neurogenesis have been associated with several human neurological and psychiatric diseases such as epilepsy, Alzheimer’s and schizophrenia. In addition adult-born neurons have also been used to study neuronal development.

Our lab aims to understand how experience and neuronal activity contribute to the differentiation of adult neural stem cells and the integration of adult-born neurons into functional circuits in the dentate gyrus. We also study how this neuronal maturation process is altered in disease.

We use in-vivo 2-photon imaging as a powerful tool to study neuronal morphology and activity in the dentate gyrus since it allows for the recurrent probing of individual cells and circuits while keeping sensory input, neuronal activity patterns, and the physiological environment intact.

Selected Publications

Mansour A.F., Gonçalves J.T., Bloyd C.W., Li H., Fernandes S., Quang D., Johnston S., Parylak S.L., Jin X, Gage F.H., An in vivo model of functional and vascularized human brain organoids, Nat. Biotechnol. , doi:10.1038/nbt.4127 (2018)

O’Donnell C., Gonçalves J.T., Portera-Cailliau C., Sejnowski T.J., Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders, eLife, 6:e26724 (2017)

O’Donnell C., Gonçalves J.T., Whiteley N., Portera-Cailliau C., Sejnowski T.J., The population tracking model: A simple, scalable statistical model for neural population data, Neural Computation, 29, 50-93 (2017)

Gonçalves J. T. *, Schafer S.T. * (equal contribution), Gage F.H., Adult neurogenesis in the hippocampus: from stem cells to behavior, Cell, 167, 897-914 (2016) review article

Gonçalves J.T., Bloyd C.W., Shtrahman M, Johnston S.T., Schafer S.T., Parylak S.L., Thanh T., Chang T., Gage F.H., In vivo imaging of dendritic pruning in dentate granule cells, Nat. Neurosci., 19(6), 788-791 (2016) (journal cover)

Poo M.M., Pignatelli M., Ryan T.J., Tonegawa S., Bonhoeffer T., Martin K.C., Rudenko A., Tsai L., Tsien R.W., Fishell G., Mullins C., Gonçalves J.T., Shtrahman M., Johnston S.T., Gage F.H., Dan Y., Long J. Buzsáki G., Stevens C., What is memory? The present state of the engram, BMC Biology, 14(1):40 (2016) opinion article

Mertens J., Paquola A. C. M., Ku M., Hatch E., Böhnke L., Ladjevardi S., McGrath S., Campbell B., Lee H., Herdy J. R., Gonçalves J. T., Toda T., Kim Y., Winkler J., Yao J., Hetzer M. and Gage F. H., Directly reprogrammed human neurons retain age-related transcriptomic signatures and reveal age-related nucleocytoplasmic defects, Cell Stem Cell, 17, 1-14 (2015)

Gonçalves J.T., Anstey J.E., Golshani P., Portera-Cailliau C., Circuit level defects in the developing neocortex of fragile X mice, Nat. Neurosci., 16, 903-09 (2013)

(equal contribution) Cheng A.*, Gonçalves J.T. *, Golshani P., Arisaka K., Portera-Cailliau C., Spatio-temporal excitation-emission multiplexing for multiple beam 2-photon calcium imaging in deep tissue, Nat. Methods., 8, 139-42 (2011)

Golshani P., Gonçalves J.T., Khoshkhoo S., Mostany R., Smirnakis S., Portera-Cailliau C., Internally mediated developmental desynchronization of neocortical network activity, J. Neurosci., 29, 10890-10899 (2009)

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More Information About Dr. J. Tiago Goncalves

http://goncalveslab.org

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Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 236
Bronx, NY 10461

Tel: 718.430.8524
Fax: 718.430.8821

Research Information