Research Assistant Professor, Department of Orthopaedic Surgery
Dr. Saad earned his Doctorate degree in Human Molecular Genetics from University of Padua, Italy. He completed his Postdoctoral training at the Department of Orthopaedic Surgery of Harvard Medical School. His research of interest is aimed at exploring the molecular mechanisms that regulate certain aspects of skeletal components such as bone, cartilage, tendon and ligaments. Understanding such mechanisms is clinically relevant to many diseases such as Osteoporosis, Osteoarthritis, Rheumatoid Arthritis and Tendinopathy and may provide the means for therapeutic interventions for these disorders that include gene and adult stem cell therapies.
Dr. Saad is an Editorial Board Member of both the Journal of Orthopaedics & Rheumatology, and Annals of Orthopaedics & Rheumatology.
Saad FA. Searching for the Molecular Pathways Regulating Bone Mineral Density in the Proteome and RNA Interference Era. J Orthop Rheumatol 1:7-13, 2013.
Saad FA, Leong DJ, Wanich TS, Gruson KI, Sun HB. Tendon stem cell: A possible solution for tendon injury repair and aging. Ann Orhop Rheumatol 1:105-106, 2013.
Saad FA. Exploration for the molecular pathways that regulate bone matrix mineralization in the proteome era. Current Topics in Biochemical Research 14:29-33, 2012.
Kaza E, Ablasser K, Poutias D, Griffiths ER, Saad FA, Hofstaetter JG, del Nido PJ, Friehs I. Up-regulation of soluble vascular endothelial growth factor receptor-1 prevents angiogenesis in hypertrophied myocardium. Cardiovasc Res. 89:410-418, 2011.
Saad FA, Hofstaetter JG. Proteomic analysis of mineralising osteoblasts identifies novel genes related to bone matrix mineralisation. Int Orthop. 35:447-451, 2011.
Saad FA, Torres M, Wang H, Graham L. Intracellular lysyl oxidase: effect of a specific inhibitor on nuclear mass in proliferating cells. Biochem Biophys Res Commun. 396:944-949, 2010.
Evans CH, Liu FJ, Glatt V, Hoyland JA, Kirker-Head C, Walsh A, Betz O, Wells JW, Betz V, Porter RM, Saad FA, Gerstenfeld LC, Einhorn TA, Harris MB, Vrahas MS. Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage. Eur Cell Mater. 18:96-111, 2009.
Saad FA, Salih E, Glimcher MJ. Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification. J Cell Biochem.103:852-856, 2008.
Hofstaetter JG, Saad FA, Sunk IG, Bobacz K, Friehs I, Glimcher MJ. Age-dependent expression of VEGF isoforms and receptors in the rabbit anterior cruciate ligament. Biochim Biophys Acta.1770:997-1002, 2007.
Hofstaetter JG, Wunderlich L, Samuel RE, Saad FA, Choi YH, Glimcher MJ. Systemic hypoxia alters gene expression levels of structural proteins and growth factors in knee joint cartilage. Biochem Biophys Res Commun. 330:386-394, 2005.
Hofstaetter JG, Saad FA, Samuel RE, Wunderlich L, Choi YH, Glimcher MJ. Differential expression of VEGF isoforms and receptors in knee joint menisci under systemic hypoxia. Biochem Biophys Res Commun. 324:667-672, 2004.
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 140
Bronx, NY 10461