Assistant Professor, Department of Genetics
Systems Developmental Biology
We focus on two major research areas:
1- Stem cell proliferation, muscle differentiation and regeneration:
Muscle diseases occur due to genetic-, injury- or aging-related causes. It is crucial to discover the gene regulatory network that controls the differentiation of muscle cells to be able to induce adult muscle stem cells to proliferate and differentiate. Moreover, the regulation of metabolism in muscle cells needs deeper understanding to prevent and cure metabolic defects, such as insulin resistance in muscle cells. We are investigating how the proliferation, differentiation and metabolism of the muscle stem cells are controlled by the signaling pathways and their transcription factor targets. We are investigating the roles of these transcription factors by loss- and gain-of-function experiments followed by detailed investigation of the impacts of these perturbations on: muscle stem cell proliferation, muscle differentiation and regeneration, and metabolism in muscle cells. Genome-wide studies, molecular perturbation experiments and imaging will be integrated to achieve these objectives.
2- Gene expression oscillations and vertebral segmentation:
The axis of vertebrates is characterized by the iteration of vertebrae. The precursors of the vertebrae are derived from embryonic somite segments. Embryos elongate from their posterior end and a new somite appears at a species-specific pre-determined time. The periodicity of this spatial pattern formation is controlled by a gene-expression oscillator, called the segmentation clock that ticks in the cells residing in the unsegmented tissue. Breakdown of the oscillations disrupts somite boundaries and results in vertebral defects. It is important to identify the genes involved at different stages of segmentation in order to develop future therapies for patients. We aim to identify novel regulators of vertebral segmentation and integrate the experimental data with mathematical modeling to unravel the regulatory network that paces the rhythm of the periodic gene expression and spatial pattern formation.
Please visit our lab website for further information: https://sites.google.com/site/ozbudaklab/home
ResearchGate Profile: https://www.researchgate.net/profile/Ertugrul_Ozbudak/?ev=hdr_xprf
Google Scholar Profile:http://scholar.google.com/citations?user=awIzgXAAAAAJ&hl=en
More Information About Dr. Ertugrul Ozbudak
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Ullmann Building, Room 711
Bronx, NY 10461