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Faculty Profile

Gregoire Lauvau, Ph.D.

Dr. Gregoire Lauvau

Professional Interests

Immune effector cell differentiation & protective host responses against microbial pathogens in vivo

Microbial pathogens invasion usually triggers potent host immune responses, however efficient protection and pathogen killing require the presence of effector cells and combinations of inflammatory signals that are ill-defined in most infections.

Our work therefore focuses on precisely defining these events in vivo. Specifically, we investigate (i) the inflammatory signals and related pathways, and innate immune cells that regulate T cell differentiation, and (ii) the cross-talks between memory T cells and innate immune cells during recall infections. Innate immune cells include monocytes, macrophages, dendritic cells and lymphocytes. We also use various models of acute infections in mice, namely the bacteria Listeria monocytogenesStreptococcus pneumoniae, the viruses Vesicular Stomatitis virus and Murine Cytomegalovirus and the parasites Plasmodium yoelii and Toxoplasma gondii. We take advantage of a range of advanced fluorescent-tracer based methodologies to monitor immune cells in situ. We use cell transfer experiments and novel genetically modified mice models in which dynamic cell functions can be monitored and/or in which functional subsets of immune cells can be selectively eliminated.

Overall, the goal of my laboratory is to improve our fine understanding of the factors that orchestrate antimicrobial host protective immune responses in vivo. We believe that our work will contribute to better immune cell-mediated preventive and therapeutic vaccination strategies.

Current labroratory members:

Emily Spaulding, Ph. D. Student

Laurent Chorro, Ph. D., Postdoctoral fellow

Saidi M'Homa Soudja, Ph. D., Postdoctoral fellow


Selected Publications

A.   Original Articles (Selected):

  1. Chandrabos C.*, M’Homa Soudja S. *, Weinrick B., Gros M., Frangaj A., Rahmoun M., Jacobs W.R. Jr. and G. Lauvau. 2014. The p60 and NamA Autolysins from Listeria monocytogenes Contributes to Host Colonization and Induction of Protective Memory. Cell Microbiol, in press.
  2. Anne L. Ruiz,, Saidi M’Homa Soudja, Cyril Deceneux, Grégoire Lauvau and Julien C. Marie. 2014. NK1.1+ CD8+ T Cells Escape TGFbeta control and Contribute to Early Microbial Pathogen response. 2014. Nature Communication, in press.
  3. SoudjaM’Homa S., Jacob E., Chandrabos C., M. Veenstra, Palliser D. and G. Lauvau. 2014. Memory T cell-derived IFN-g instructs potent innate cell activation for protective immunity. Immunity, 40(6):974-88.
  4. SoudjaM’Homa S., Ruiz A. L., Marie J. C., and G. Lauvau.2012.Inflammatory monocytes switch on memory CD8+ T and innate NK lymphocytes during microbial pathogens invasion. Immunity, 37(3):549-62.
  5. Narni-Mancinelli E., Soudja M’Homa S., Crozat K., Dalod M., Gounon P., Geissmann F. and G. Lauvau. 2011. Inflammatory monocytes and neutrophils are licensed to kill during Memory responses in vivo. PLoS Pathogens, Vol 7(12):e1002457.
  6. Campisi L., S. SoudjaM’Homa, N. Cagnard, J. Cazareth, D. Bassand, A. Lazzari, E. Narni-Mancinelli, F. Brau, N. Glaichenhaus, F. Geissmann and G. Lauvau. 2011. Splenic CD8a+ Dendritic Cells Undergo Rapid Programming by Cytosolic Bacteria and Inflammation to Induce Protective CD8 Memory. Eur J Immunol, 41(6):1594-605.
  7. Bajénoff M., Narni-Mancinelli E., Brau F., and G. Lauvau. 2010. Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria. PLoS One. 5:11524.
  8. Auffray C.*, D.  K. Fogg*, E. Narni-Mancinelli*, B. Senechal, C. Touillet, N. Saederup, J. Leemput, K. Bigot, L. Campisi, M. Abitbol, T. Molina 1, I. Charo, D. A. Hume, A. Cumano, G. Lauvau and F. Geissmann. 2009. CX3CR1+ CD115+ CD135+ common macrophage/DC precursor (MDP) and the role of CX3CR1 in their response to inflammation. J Exp Med, 206: 595-606.
  9. Narni-Mancinelli E., L. Campisi, D. Bassand, J. Cazareth, P. Gounon, N. Glaichenhausand G. Lauvau. 2007. Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J Exp Med, 204: 2075-2087.
  10. Auffray, C., D. K. Fogg, Meriem Garfa, G. Elain, O. Join-Lambert, S. Kayal, S. Sarnacki, A. Cumano, G. Lauvau and F. Geissmann.2007. Patrolling blood monocytes that monitor blood vessels and tissues for damage and infection. Science, 317, 666-70.
  11. Muraille, E.*, E. Narni-Mancinelli*, P. Gounon*, D. Bassand, N. Glaichenhaus, L. L. Lenz, and G. Lauvau. 2007. Cytosolic Expression of SecA2 is a Prerequisite for Long-Term Protective Immunity. Cell Microbiol, 9, 1445-1454.
  12. Muraille, E., R. Giannino, P. Guirnalda, I. Leiner, S. Jung, E. G. Pamerand G. Lauvau. 2005. Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes. Eur J Immunol, 35:1-9.
  13. Lauvau, G*., S. Culina*, B. Gubler, and P.M. van Endert. 2004. Calreticulin promotes folding of functional HLA class I molecules in vitro. J Biol Chem, 279:54210-54215.
  14. Lauvau, G.*, S. Vijh*, P. Kong, T. Horng, K. Kerksiek, N. Serbina, R.A. Tuma, and E.G. Pamer. 2001. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science, 294:1735-1739.
  15. Lauvau, G*., B. Gubler*, H. Cohen, S. Daniel, S. Caillat-Zucman, and P.M. van Endert. 1999. Tapasin enhances assembly of transporters associated with antigen processing-dependent and -independent peptides with HLA-A2 and HLA-B27 expressed in insect cells. J Biol Chem, 274:31349-31358.
  16. Lauvau, G., K. Kakimi, G. Niedermann, M. Ostankovitch, P. Yotnda, H. Firat, F.V. Chisari, and P.M. van Endert. 1999. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells. J Exp Med, 190:1227-1240.

B.   Review Articles/Chapters:

  1. Lauvau G., L. Chorro, E. Spaulding, S. M’Homa Soudja. 2014. Inflammatory Monocyte Effector Mechanisms. Cellular Immunology, S0008-8749(14)00125-7.
  2. Lauvau G., M’Homa Soudja S., Chorro L. 2013. T cell Memory. Encyclopedia of Medical Immunology, I.R. Mackay, N.R. Rose (eds.), Springer Science, DOI 10.1007/978-0-387-84828-0.
  3. Geissmann F., C. Auffray, R. Palframan, C. Wirrig, A. Ciocca, L. Campisi, E. Narni-Mancinelli, and G. Lauvau. 2008. Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T cell responses. Immunology and Cell Biology, 86:398-408.

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.


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