Faculty Profile

Dr. Gregoire Lauvau, Ph.D.

Gregoire Lauvau, Ph.D.

Professor, Department of Microbiology & Immunology

Areas of Research: Our goal is to advance the mechanistic understanding -cellular and gene regulation- of host protective immune mechanisms in the context of vaccines and microbial pathogen infections as well as tumors.

Professional Interests

Immune effector cell differentiation & protective host responses against microbial pathogens and tumors in vivo

We have three funded research themes in the laboratory that focus on:

1. The functional differentiation of naive and memory CD8+ T cells: we have built experimental systems in mice to assess the roles of cognate antigen in the functional fates of memory CD8 T cells and their ability to mediate host protection. Our goal is to provide a comprehensive understanding of i) how to generate functionally and epigenetically distinct memory CD8 T cells and ii) how to harness memory CD8 T cell protective mechanisms to the benefit of the host for new T cell therapies.

2. Immunity to malaria: we investigate i) the mechanisms of severe malaria, focusing on the role of type I interferon promoting poor clinical outcomes. We study a functional cell/cell interaction that occurs between macrophages and plasmacytoid dendritic cells in the bone marrow of infected mice and accounts for type I IFN production.  We also investigate ii) the role of a subset of circulating memory CD4 T cells we found expanded in Malawian patients clinically protected against Plasmodium falciparum using cytometry by time of flight (CyTOF). We are conducting high throughput "omic" approaches to reveal and functionally test the CD4 T cell program associated with clinical protection against this number one killer parasite worldwide.

3. A new clinically relevant model of breast cancer: we are characterizing a novel stem-cell based model of breast cancer in which several clinically relevant mutations have been introduced. This model mimics several key aspects of highly aggressive human breast cancers. We investigate mechanisms of immune escape and anti-tumor therapies.

Our laboratory has developed multiple tools (pathogen, mice), as well as cutting edge approaches that include transcriptomic, single cell transcriptomics, epigenetic and intravital microscopy in close collaboration with other groups at Einstein. Our overall goal is to improve our fine understanding of the factors that orchestrate antimicrobial and antitumoral host protective immune responses in vivo. We believe that our work will contribute to more rationale design of immune cell-mediated preventative and therapeutic strategies.


Current laboratory members:

  • Jamie Moore, M. D./Ph. D. Student
  • Marie Boutet, Ph. D., Postdoctoral fellow
  • Mandy Shu Shien Chin, Ph. D., Postdoctoral fellow
  • Raquel Furtado, Ph. D., Postdoctoral fellow

Selected Publications

A.   Original Articles (Selected):

  1. Spaulding E., D. Fooksman, A. Saidi, C. Feintuch, B. Reizis, J. Daily and G. Lauvau. 2016. STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria. PLoS Pathogens, 12(10):e1005975.
  2. Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL, Hugues S, Longhi MP, Henry JY, Quezada SA, Lauvau G, Lennon-Duménil AM, Gutiérrez-Martínez E, Bessis A, Gomez-Perdiguero E, Jacome-Galarza CE, Garner H, Geissmann F, Golub R, Nussenzweig MC, Guermonprez P. 2016. The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells. Immunity, 45(6):1205-1218.
  3. Subramaniam K.S., Spaulding E., Ivan E., Mutimura E., Kim R.S., Liu X., Dong C., Feintuch C.M., Zhang X., Anastos K., Lauvau G. and Daily J.P. 2015. The T cell inhibitory molecule BTNL2 is upregulated in mild Plasmodium falciparum infection and is protective during experimental cerebral malaria. J Infect Dis, Apr 15. pii: jiv217..
  4. Chandrabos C.*, M’Homa Soudja S. *, Weinrick B., Gros M., Frangaj A., Rahmoun M., Jacobs W.R. Jr. and G. Lauvau. 2014. The p60 and NamA Autolysins from Listeria monocytogenes Contributes to Host Colonization and Induction of Protective Memory. Cell Microbiol, 17(2):147-63.
  5. Anne L. Ruiz,, Saidi M’Homa Soudja, Cyril Deceneux, Grégoire Lauvau and Julien C. Marie. 2014. NK1.1+ CD8+ T Cells Escape TGFbeta control and Contribute to Early Microbial Pathogen response. 2014. Nature Communication, 5:5150.
  6. Soudja M’Homa S., Jacob E., Chandrabos C., M. Veenstra, Palliser D. and G. Lauvau. 2014. Memory T cell-derived IFN-g instructs potent innate cell activation for protective immunity. Immunity, 40(6):974-88.
  7. Soudja M’Homa S., Ruiz A. L., Marie J. C., and G. Lauvau.2012.Inflammatory monocytes switch on memory CD8+ T and innate NK lymphocytes during microbial pathogens invasion. Immunity, 37(3):549-62.
  8. Narni-Mancinelli E., Soudja M’Homa S., Crozat K., Dalod M., Gounon P., Geissmann F. and G. Lauvau. 2011. Inflammatory monocytes and neutrophils are licensed to kill during Memory responses in vivo. PLoS Pathogens, Vol 7(12):e1002457.
  9. Campisi L., S. SoudjaM’Homa, N. Cagnard, J. Cazareth, D. Bassand, A. Lazzari, E. Narni-Mancinelli, F. Brau, N. Glaichenhaus, F. Geissmann and G. Lauvau. 2011. Splenic CD8a+ Dendritic Cells Undergo Rapid Programming by Cytosolic Bacteria and Inflammation to Induce Protective CD8 Memory. Eur J Immunol, 41(6):1594-605.
  10. Bajénoff M., Narni-Mancinelli E., Brau F., and G. Lauvau. 2010. Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria. PLoS One. 5:11524.
  11. Auffray C.*, D.  K. Fogg*, E. Narni-Mancinelli*, B. Senechal, C. Touillet, N. Saederup, J. Leemput, K. Bigot, L. Campisi, M. Abitbol, T. Molina 1, I. Charo, D. A. Hume, A. Cumano, G. Lauvau and F. Geissmann. 2009. CX3CR1+ CD115+ CD135+ common macrophage/DC precursor (MDP) and the role of CX3CR1 in their response to inflammation. J Exp Med, 206: 595-606.
  12. Narni-Mancinelli E., L. Campisi, D. Bassand, J. Cazareth, P. Gounon, N. Glaichenhausand G. Lauvau. 2007. Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J Exp Med, 204: 2075-2087.
  13. Auffray, C., D. K. Fogg, Meriem Garfa, G. Elain, O. Join-Lambert, S. Kayal, S. Sarnacki, A. Cumano, G. Lauvau and F. Geissmann.2007. Patrolling blood monocytes that monitor blood vessels and tissues for damage and infection. Science, 317, 666-70.
  14. Muraille, E.*, E. Narni-Mancinelli*, P. Gounon*, D. Bassand, N. Glaichenhaus, L. L. Lenz, and G. Lauvau. 2007. Cytosolic Expression of SecA2 is a Prerequisite for Long-Term Protective Immunity. Cell Microbiol, 9, 1445-1454.
  15. Muraille, E., R. Giannino, P. Guirnalda, I. Leiner, S. Jung, E. G. Pamerand G. Lauvau. 2005. Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes. Eur J Immunol, 35:1-9.
  16. Lauvau, G*., S. Culina*, B. Gubler, and P.M. van Endert. 2004. Calreticulin promotes folding of functional HLA class I molecules in vitro. J Biol Chem, 279:54210-54215.
  17. Lauvau, G.*, S. Vijh*, P. Kong, T. Horng, K. Kerksiek, N. Serbina, R.A. Tuma, and E.G. Pamer. 2001. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science, 294:1735-1739.
  18. Lauvau, G*., B. Gubler*, H. Cohen, S. Daniel, S. Caillat-Zucman, and P.M. van Endert. 1999. Tapasin enhances assembly of transporters associated with antigen processing-dependent and -independent peptides with HLA-A2 and HLA-B27 expressed in insect cells. J Biol Chem, 274:31349-31358.
  19. Lauvau, G., K. Kakimi, G. Niedermann, M. Ostankovitch, P. Yotnda, H. Firat, F.V. Chisari, and P.M. van Endert. 1999. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells. J Exp Med, 190:1227-1240.

 

B.   Review Articles/Chapters:

  1. Lauvau, G., M. Boutet, T.M. Williams, M. Shu Shien Chin and L. Chorro. Memory CD8+ T Cells: Innate-Like Sensors and Orchestrators of Protection. 2016. Trends in Immunology, 37(6):375-85.
  2. Lauvau, G. and S. Goriely. Memory CD8 T cells: Orchestrators and Key Players of Innate Immunity? 2016. PLoS Pathogens, 12(9):e1005722.
  3. Lauvau G., Loke P., Holh T.M. Monocyte Mediated Defense Against Pathogenic Microbes. 2016. Seminars in Immunology, 27(6):397-409.
  4. Lauvau G., S. M’Homa Soudja. 2015. Mechanisms of Memory T Cell Activation and Effective Immunity. Adv Exp Med Biol, 850:73-80.
  5. Lauvau G. 2015. PI3-kinase, the key for bugs to get in? J Exp Med, 9;212(2):127.
  6. Lauvau G., L. Chorro, E. Spaulding, S. M’Homa Soudja. 2014. Inflammatory Monocyte Effector Mechanisms. Cellular Immunology, S0008-8749(14)00125-7.
  7. Lauvau G., M’Homa Soudja S., Chorro L. 2013. T cell Memory. Encyclopedia of Medical Immunology, I.R. Mackay, N.R. Rose (eds.), Springer Science, DOI 10.1007/978-0-387-84828-0.
  8. Geissmann F., C. Auffray, R. Palframan, C. Wirrig, A. Ciocca, L. Campisi, E. Narni-Mancinelli, and G. Lauvau. 2008. Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T cell responses. Immunology and Cell Biology, 86:398-408.

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue , Room 520
Bronx, NY 10461

Tel: 718.678.1188
Fax: 718.678.1085

Research Information