Faculty Profile

Dr. Orsolya Giricz, Ph.D.

Orsolya Giricz, Ph.D.

Associate, Department of Medicine (Oncology)

Selected Publications

Shah UA, Chung EY, Giricz O, Pradhan K, Kataoka K, Gordon-Mitchell S, Bhagat TD, Mai Y, Wei Y, Ishida E, Choudhary GS, Joseph A, Rice R, Gitego N, Parrish C, Bartenstein M, Goel S, Mantzaris I, Shastri A, Derman O, Binder A, Gritsman K, Kornblum N, Braunschweig I, Bhagat C, Hall J, Graber A, Ratner L, Wang Y, Ogawa S, Verma A, Ye BH, Janakiram M.
North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Blood. 2018 Aug 13.

Giricz O, Mo Y, Dahlman KB, Cotto-Rios XM, Vardabasso C, Nguyen H, Matusow B, Bartenstein M, Polishchuk V, Johnson DB, Bhagat TD, Shellooe R, Burton E, Tsai J, Zhang C, Habets G, Greally JM, Yu Y, Kenny PA, Fields GB, Pradhan K, Stanley ER, Bernstein E, Bollag G, Gavathiotis E, West BL, Sosman JA, Verma AK.
The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.
JCI Insight. 2018 Jul 25;3(14).

Landgren O*, Zeig-Owens R*, Giricz O*, Goldfarb D, Murata K, Thoren K, Ramanathan L, Hultcrantz M, Dogan A, Nwankwo G, Steidl U, Pradhan K, Hall CB, Cohen HW, Jaber N, Schwartz T, Crowley L, Crane M, Irby S, Webber MP, Verma A, Prezant DJ.
Multiple Myeloma and Its Precursor Disease Among Firefighters Exposed to the World Trade Center Disaster.
JAMA Oncol. 2018 Jun 1;4(6)

Bhagat TD, Chen S, Bartenstein M, Barlowe AT, Von Ahrens D, Choudhary GS, Tivnan P, Amin E, Marcondes AM, Sanders MA, Hoogenboezem RM, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Laurence R, Lopez R, Bhagat P, Giricz O, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Zhang J, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Will B, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG, Verma A.
Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.
Cancer Res. 2017 Sep 15;77(18)

Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K.
Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer.
J Biol Chem. 2017 Jan 20;292(3)

Bachegowda L, Morrone K, Winski SL, Mantzaris I, Bartenstein M, Ramachandra N, Giricz O, Sukrithan V, Nwankwo G, Shahnaz S, Bhagat T, Bhattacharyya S, Assal A, Shastri A, Gordon-Mitchell S, Pellagatti A, Boultwood J, Schinke C, Yu Y, Guha C, Rizzi J, Garrus J, Brown S, Wollenberg L, Hogeland G, Wright D, Munson M, Rodriguez M, Gross S, Chantry D, Zou Y, Platanias LC, Burgess LE, Pradhan K, Steidl U, Verma A
Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia.
Cancer Res. 2016 Jun 10.

Schinke C, Giricz O, Li W, Shastri A, Gordon S, Barreryo L, Bhagat T, Bhattacharyya S, Ramachandra N, Bartenstein M, Pellagatti A, Boultwood J, Wickrema A, Yu Y, Will B, Wei S, Steidl U, Verma A
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.
Blood. 2015 Mar 25

Shrivastava MS, Hussain Z, Giricz O, Shenoy N, Polinenia R, Maitrab A, Verma A
Targeting chemokine pathways in esophageal adenocarcinoma
Cell Cycle 2014 Nov 14.13(21)

Hu CY, Mohtat D, Yu Y, Ko YA, Shenoy N, Bhattacharya S, Izquierdo MC, Park AS, Giricz O, Vallumsetla N, Gundabolu K, Ware K, Bhagat TD, Suzuki M, Pullman J, Liu XS, Greally JM, Susztak K, Verma A.
Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival.
Clin Cancer Res. 2014 Aug 15;20(16):4349-60

Miwa H, Koba W, Fine E, Giricz O, Kenny PA, Stanley P
Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer
Glycobiology 2013 Dec;23(12):1477-90.

Giricz O, Calvo V, Peterson EA, Abouzeid C, Kenny PA
TACE-dependent TGF-alpha shedding drives triple-negative breast cancer cell invasion
Int J Cancer. 2013 Jun 1. 2013 Dec 1;133(11):2587-95

Yu Y, Mo Y, Ebenezer D, Bhattacharyya S, Liu H, Sundaravel S, Giricz O, Wontakal S, Cartier J, Caces B, Artz A, Nischal S, Bhagat T, Bathon K, Maqbool S, Gligich O, Suzuki M, Steidl U, Godley L, Skoultchi A, Greally J, Wickrema A, Verma A
High Resolution Methylome Analysis Reveals Widespread Functional Hypomethylation during Adult Human Erythropoiesis
J Biol Chem. 2013 Mar 29;288(13):8805-14.

Giricz O, Reynolds PA, Ramnauth A, Liu C, Wang T, Stead L, Childs G, Rohan T, Shapiro N, Fineberg S, Kenny PA, Loudig O
Hsa-miR-375 Is Differentially Expressed During Breast Lobular Neoplasia And Promotes Loss Of Mammary Acinar Polarity
J Pathol 2012 Jan;226(1):108-19.

Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA, Kenny PA.
GRB7 is required for triple-negative breast cancer cell invasion and survival.
Breast Cancer Res Treat. 2011: 2011 Oct 18.

Giricz O, Lauer JL, Fields GB.
Comparison of Metalloproteinase Protein and Activity Profiling
Anal Biochem. 2010 Oct 1 2011 Feb 1;409(1):37-45.

Han J, Chang H, Giricz O, Lee GY, Baehner FL, Gray JW, Bissell MJ, Kenny PA, Parvin B.
Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture.
PLoS Comput Biol. 2010 Feb 26;6(2):e1000684.

Giricz O, Lauer JL, Fields GB.
Variability in Melanoma Metalloproteinase Profiling
J Biomol Tech.2010 Dec; 21(4): 194–204.

Giricz O, Lauer-Fields JL, Fields GB.
The normalization of gene expression data in melanoma: investigating the use of glyceraldehyde 3-phosphate dehydrogenase and 18S ribosomal RNA as internal reference genes for quantitative real-time PCR.
Anal Biochem. 2008 Sep 1;380(1):137-9

 

 

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Research Information