Faculty Profile

Dr. Ely S. Simon, M.D.

Ely S. Simon, M.D.

Clinical Assistant Professor, The Saul R. Korey Department of Neurology

Areas of Research: Cognitive and behavioral neurology, pain and headache: Focus on development and study of technology-based assessment and disease management tools, including patient-centric digital health applications.

Professional Interests

Dr. Ely Simon is a neurologist, biomedical engineer, and entrepreneur. He graduated from Case Western Reserve University School of Medicine, and complete residency in neurology at Albert Einstein College of Medicine. He served as the Director of the Center for Memory and Attention Disorders at Tel Aviv Sourasky Medical Center in Israel, and was the founder of NeuroTrax, a company that developed a pioneering system for computerized cognitive assessment used clinically, and was Senior Research Fellow at the Laboratory of Neural Control at the NIH.

Dr. Simon's current research interests are in the areas of cognitive and behavioral neurology, with specific emphasis on behavioral therapeutics for headache and chronic pain. Past projects have involved development of computerized cognitive assessment, with application to mild cognitive impairment, dementia, and other neurodegenerative diseases.

Dr. Simon serves on the Scientific Advisory Board of the Alzheimer's Drug Development Foundation, and is an ad-hoc reviewer for numerous journals. He has published over 50 original journal articles in the fields of neurology, physiology, and behavioral medicine.

Selected Publications

  1. H. Chizeck, R. Kobetic, E.B. Marsolais, J.J. Abbas, I.H. Donner, E.S. Simon.
    Control of Functional Neuromuscular Stimulation (FNS) Systems for Standing and Locomotion in Paraplegics.
    Proceedings of the IEEE; 76: 1155-1165;1988.
  2. E.S. Simon, A.M. Hegarty, M.F. Mehler.
    Hemispatial and Directional Performance Biases in Motor Neglect.
    Neurology; 45: 525-531;1995.
  3. E.S. Simon.
    Involvement of Glycine and GABAA in the Pathogenesis of Spinal Myoclonus: In Vitro Studies in the Isolated Neonatal Rodent Spinal Cord.
  4. E.S. Simon. 
    Changes in Spinal Recurrent Inhibition in Patients During the Immediate Post-Stroke Period.
    Journal of Neurologic Rehabilitation;10:35-42;1996.
  5. J.-P. Gossard, M.-K. Floeter, A.M. Degtyarenko, E.S. Simon, R.E. Burke.  Disynaptic Vestibulospinal and Reticulospinal Excitation in Cat Lumbosacral Motoneurons: Modulation During Fictive Locomotion.
    Experimental Brain Research;109:277-288;1996.
  6. A. M. Degtyarenko, E.S. Simon, R.E. Burke.
    Differential Modulation of Disynaptic Cutaneous Inhibition and Excitation in Ankle Flexor Motoneurons During Fictive Locomotion.
    Journal of Neurophysiology;76:2972-2985;1996.
  7. E.S. Simon.
    Phenotypic Heterogeneity and Disease Course of Three Murine Strains With Mutations of Genes Encoding α1 and β Glycine Receptor Subunits.
    Movement Disorders;12:221-228;1997.
  8. A.M. Degtyarenko, E.S. Simon, T. Norden-Krichmar and R.E. Burke.
    Modulation of Oligosynaptic Cutaneous and Muscle Afferent Reflex Pathways During Fictive Locomotion and Scratching in the Cat.
    Journal of Neurophysiology;79:447-463;1998.
  9. A.M. Degtyarenko, E.S. Simon,and R.E. Burke.
    Locomotor Modulation of Disynaptic EPSPs from the Mesencephalic Locomotor Region in Cat Motoneurons.
    Journal of Neurophysiology;80:3284-3296;1998.
  10. E.S. Simon, E. Kahana, J. Chapman, T.A. Treves, R. Gabizon, H. Rosenmann, N. Zilber, A.D. Korczyn.
    Creutzfeldt-Jakob Disease Profile in Patients Homozygous for the PRNP E200K mutation.
    Annals of  Neurology, 47:257-260;2000.
  11. N. Giladi, T.A. Treves, D. Paleacu, H. Shabtai, Y. Orlov, B. Kandinov, E.S. Simon,
    A.D. Korczyn.
    Risk Factors for Dementia, Depression and Psychosis in Long-Standing Parkinson's Disease.
    Journal of Neural Transmission, 107:59-71;2000.
  12. N. Giladi, H. Shabtai, E.S. Simon, S. Biran, J. Tal, A.D. Korczyn.
    Construction of  Freezing of Gait Questionnaire for Patients with Parkinson's disease.
    Parkinsonism and Related Disorders, 6:165-170;2000.
  13. N. Giladi, E.S. Simon, A.D. Korczyn, G.B. Groozman, Y. Orlov, H. Shabtai, V.E. Drory.
    Anal Sphincter Electromyography Does Not Differentiate Between Patients with Multi-System Atrophy (MSA) and Parkinson's Disease.
    Muscle & Nerve, 23:731-734;2000.
  14. A. Mazarib, E.S. Simon, A.D. Korczyn, Z. Falik-Zaccai, E. Gazit, N. Giladi
    Heriditary Juvenile Onset, Cranio-cervical Predominant, Generalized Dystonia with Parkinsonism.
    Israel Medical Association Journal 2:529-531: 2000.
  15. N. Giladi, T.A. Treves, E.S. Simon, H. Shabtai, Y. Orlov, B. Kandinov, D. Paleacu, A.D. Korczyn.
    Freezing of Gait in Patients with Advanced Parkinson's Disease.
    Journal of Neural Transmission 108:53-61:2001.
  16. H. Ben-Pazi, H. Bergman, D. Hansel, J. Goldberg, N. Giladi, A. Reches, E.S. Simon.
    Low Interlimb Coherence in Parkinsonian Rest Tremor.
    Journal of Neural Transmission, 108:287-296:2001.
  17. R.E. Burke, A.M. Degtyarenko, E.S. Simon
    Pattern of Drive to Motoneurons and Last-order Interneurons During Fictive Locomotion: Clues to the Structure of the Central Pattern Generator
    Journal of Neurophysiology 86:447-462:2001.
  18. A.T. Portman, N. Giladi, K.L. Leenders, P. Maguire, L. Veenma-Van Der Duin, J. Swart, J. Pruim, E.S. Simon, S. Hassin-Baer, A.D. Korczyn
    The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations.
    Neurology 56:1759-1762:2001.
  19. N. Giladi, T. Gurevich, H. Shabtai, D. Paleacu, E.S. Simon
    The Effect of Botulinum Toxin Injections to the Calf Muscles on Freezing of Gait in Parkinsonism: A Pilot Study.
    Journal of Neurology, 248:572-576:2001.
  20. N. Sapir, R. Karasik, S. Havlin, E.S. Simon, J.M. Hausdorff.
    Detecting scaling in the period dynamics of multimode signals:  Application to parkinsonian
    Phys Rev E: 67:031903-1-8:2003.
  21. M. Fukuda, A. Barnes, E.S. Simon, A. Holmes, V.Dhawan, N. Giladi, H. Fodstad, Y. Ma, D. Eidelberg. 
    Thalamic Stimulation for Parkinsonian Tremor: Correlation between Regional Cerebral Blood Flow and Physiological Tremor Characteristics.
    NeuroImage ,21:608-615:2004.
  22. D. Golan, N. Giladi, R. Thorne, A.D. Korczyn, E.S.Simon.
    Subdivision of essential tremor patients according to physiological characteristics.
    Acta Neurol Scand:109:393-397:2004.
  23. G. Yahalom, E.S. Simon, R. Thorne, N. Giladi.
    Rhythm Production and Timing in Parkinson's Disease.
    Parkinsonism and Related Disorders , 10:143-148:2004.
  24. T. Dwolatzky, V. Whitehead, G.M. Doniger, E.S. Simon, A. Schweiger, D. Jaffe, H. Chertkow. 
    Validity of a novel computerized cognitive battery for mild cognitive impairment.
    BMC Geriatrics, 3:4:1-12:2003.
  25. A. Schweiger, G.M. Doniger, T. Dwolatzky, D. Jaffe, E.S. Simon
    Reliability of a novel computerized neuropsychological battery for mild cognitive impairment.
    ACTA Neuropsychol, 1:4:407-413:2003.
  26. M. Fukuda, A. Barnes, E.S. Simon, A. Holmes, V.Dhawan, N. Giladi, H. Fodstad, Y. Ma, D. Eidelberg. 
    Thalamic Stimulation for Parkinsonian Tremor: Correlation between Regional Cerebral Blood Flow and Physiological Tremor Characteristics.
    NeuroImage, 21:608-615:2004.
  27. G. Yahalom, E.S. Simon, R. Thorne, N. Giladi.
    Rhythm Production and Timing in Parkinson's Disease.
    Parkinsonism and Relat Disord, 10:143-148:2004.
  28. T. Dwolatzky, V. Whitehead, G.M. Doniger, E.S. Simon, A. Schweiger, D. Jaffe, H. Chertkow. 
    Validity of the Mindstreams computerized cognitive battery for mild cognitive impairment.
    J Molec Neurosci, 24:33-44:2004.
  29. D. Elstein, J. Guedalia, G.M. Doniger, E.S. Simon, V. Antebi, Y. Arnon, A. Zimran. 
    Computerized Cognitive Testing in Patients with Type 1 Gaucher Disease: Effects of Enzyme Replacement and Substrate Reduction.
    Genetics Med, 7:124-130:2005.
  30. J.M. Hausdorff, G. Yogev, S. Springer, E.S. Simon, N. Giladi.
    Walking is more like catching than tapping: gait in the elderly as a complex cognitive task.
    Exp.Brain Res, 164:541-548:2005.
  31. G.M. Doniger, D.M. Zucker, A. Schweiger, T. Dwolatzky, and E.S. Simon.
    Towards practical cognitive assessment for detection of early dementia: A 30-minute computerized battery discriminates as well as longer testing.
    Cur Alz Res, 2:117-124:2005.
  32. G. Yogev, N. Giladi, C. Peretz , S. Springer, E.S. Simon, and J.M. Hausdorff.
    Dual tasking, gait rhythmicity, and Parkinson's disease: Which aspects of gait are attention demanding?
    Eur J Neurosci, 22, 1248-1256:2005.
  33. S. Springer, N. Giladi, C. Peretz, G. Yogev, E.S. Simon, and J.M. Hausdorff. 
    Dual tasking effects on gait variability: The role of aging, falls, and executive function.
    Mov Disord, 21:950-957:2006.
  34. G.M. Doniger, T. Dwolatzky, D.M. Zucker, H. Chertkow, H. Crystal, A. Schweiger, and E.S. Simon.
    Computerized cognitive testing battery identifies MCI and mild dementia even in the presence of depressive symptoms.
    Am J Alz Dis, 21:28-36:2006.
  35. J.M. Hausdorff, G.M. Doniger, S. Springer, G. Yogev, E.S. Simon, and N. Giladi.
    A common cognitive profile in elderly fallers and in patients with Parkinson's disease: The prominence of impaired executive function and attention.
    Exp Aging Res, 32:411-429:2006.
  36. E. Auriel, J.M. Hausdorff, T. Herman, E.S. Simon, and Giladi, N. Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: A pilot study.
    Clin Neuropharm, 29:25-17: 2006.
  37. T.Y. Gurevich, H. Shabtai, A.D. Korczyn, E.S. Simon, and N. Giladi. The effect of rivastigmine on tremor in patients with Parkinson's disease and dementia.
    Mov Disord, 21:1663-1666: 2006.
  38. G.M. Doniger, E.S. Simon, and A. Zivotofsky. Cognitive sequelae of a complete 12 to 16 hour fast.
    Behav Neurosci.,120:804-816, 2006.
  39. A. Gozolchiani, S. Moshel, J.M. Hausdorff, E. Simon, J. Kurths, S. Havlin. Decaying in Phase Synchronization of Parkinsonian Tremor.
    Physica A., 366, 522, 2006.
  40. A. Schweiger, A. Abramovitch, G.M. Doniger, and E.S. Simon. A clinical construct validity study of a novel computerized battery for the diagnosis of ADHD in young adults.
    J Clin Exp Neuropsychology, 29:100-111: 2007.
  41. Y. Leitner, G.M. Doniger, R. Barak, E.S. Simon, and J.M. Hausdorff.
    Attention deficit hyperactivity disorder: Evidence for widespread and circumscribed deficits.
    J. Child Neurol, 22:264-267: 2007.
  42. D. Paleacu, A. Shutzman, N. Giladi, T. Herman, E.S. Simon, J.M. Hausdorff.
    Effects of Pharmacological Therapy on Gait and Cognitive Function of Depressed Patients.
    Clin Neuropharm,30:63-71: 2007.
  43. Lavi, R., Doniger, G.M., Simon, E., Hochner-Celnikier, D., Zimran, A., Elstein, D.
    The effect of hormone replacement therapy on cognitive function in post-menopausal women.
    QJM: Internat J Med, 100, 567-573, 2007.
  44. A. Achiron, G.M. Doniger, Y. Harel, N. Appleboim-Gavish, M. Lavie, and E.S. Simon.
    Prolonged response times characterize cognitive performance in multiple sclerosis.
    Eur J Neurol, 14, 1102-1108, 2007.
  45. Fillit, H.M., Simon, E.S., Doniger, G.M., and Cummings, J.L.
    Practicality of a computerized system for cognitive assessment in the elderly.
    Alz Dem: J Alz Ass, 4, 14-21, 2008.
  46. Elstein, D., Doniger, G.M., Simon, E., Korn-Lubetzki, I., Navon, R., and Zimran, A..
    Neurocognitive testing in Late-onset Tay-Sachs disease: A pilot study.
    J Inherited Metabolic Dis., 31, 518-523, 2008.
  47. Doniger, G.M., Simon, E.S., and Schweiger, A.
    Adjustment of cognitive scores with a co-normed estimate of premorbid intelligence: Implementation using Mindstreams computerized testing.
    Appl Neuropsychol, 15, 250-263, 2008.
  48. Elstein, D., Doniger, G.M., Simon, E., Korn-Lubetzki, I., Navon, R., and Zimran, A. Neurocognitive testing in Late-onset Tay-Sachs disease: A pilot study.
    J. Inherited Metabolic Dis, 31, 518-523, 2008.
  49. Doniger, G.M., Jo, M-Y., Simon, E.S., and Crystal, H.A.
    Computerized cognitive assessment of mild cognitive impairment in urban African Americans. Amer. J. Alz. Dis., 24, 396-403, 2009.
  50. Dwolatzky, T., Dimant, L., Simon, E.S., and Doniger, G.M.           
    Validity of a short computerized assessment battery for moderate cognitive impairment and dementia.
    Int. Psychogeriatrics, 22, 795-803, 2010.
  51. Thaler, A., Mirelman, A., Simon, E., Orr-Urtreger, A., Gurevich, T., and Giladi, N.
    Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.
    Neurology, 79, 1027-1032, 2012.
  52. Oyama, G, Rodriguez, R.L., Jones, J.D., Swartz, C., Merritt, S., Unger, R., Hubmann, M., Delgado, A., Simon, E., Doniger, G.M., Bowers, D., Foote, K.D., Fernandez, H.H., and Okun, M.S.
    Selection of deep brain stimulation candidates in private neurology practices: Referral may be simpler than a computerized triage system.
    Neuromodulation, 5, 246-250, 2012.
  53. Cohen-Manheim, I., Doniger, G.M., Sinnrech, R., Simon, E.S., Pinchas, R., Aviv, A., and Kark, J.D.
    Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife.
    European Journal of Epidemiology, 2015.

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