Faculty Profile

Dr. Haihong Zong, M.D.

Haihong Zong, M.D.

Assistant Professor, Department of Medicine (Endocrinology)

Professional Interests

My research interest is Integrins B1 function of Diabetes. Crucial role of Integrins B1 signaling events in mediating cross-talk to Insulin action in vivo. 

Selected Publications

1)Ho D, Zhao X, Yan L, Yuan C, Zong H, et al. Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes. 2015 Mar 2;PubMed PMID: 25732192.

(2)Kwon H, Laurent S, Tang Y, Zong H, Vemulapalli P, et al. Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway. Cell Rep. 2014 Dec 11;9(5):1574-83. PubMed PMID:  25466256; PubMed Central PMCID: PMC4268106

(3)Shemesh A, Wang Y, Yang Y, Yang GS, Johnson DE, et al. Suppression of leucine supplementation. Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1251-9. PubMed PMID: 25231351; PubMed Central PMCID:  PMC4233288.

(4)Xiaoping Zhao, Xiaoli, Haihong Zong, Arian Abdulla, Ellen S.T. Yang, Qun Wang, Jun-Yuan Ji, Jeffrey E. Pessin, Bhaskar C. Das,              and Fajun Yang Inhibition of SREBP Transcriptional Activity by a Boron-Containing Compound Improves Lipid Homeostasis in Diet-Induced Obesity Diabetes July 2014 63:7 2464-2473

(5)Nuria MartinezDLopez, Diana Athonvarangkul, Srabani Sahu, Luisa Coletto, Haihong Zong,Jeffrey E Pessin, Gary J Schwartz, Rajat Singh. Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO reports(2013)14,795-803

(6)Adi Shemesh, Arian Abdulla ,Fajun Yang , Streamson C. Chua, Jeffrey E Pessin, Haihong Zong (Corresponding author). The Antidepressant Trans-2-Phenylcyclopropylamine Protects Mice from High-Fat-Diet-Induced Obesity. PLoS One. 2014 Feb 21;9(2):e89199.

(7)Ting-Wen A. Lee,Hyokjoon Kwon, Haihong Zong, Eijiro Yamada, Manu Vatish,Jeffrey E. Pessin, and Claire C. Bastie.     Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation. Diabetes 2013 Jan 15

(8)Haihong Zong, Michal Armoni, Chava Harel, Eddy Karnieli, Jeggrey E Pessin. Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2012 Mar 1 302(5):E532-9

(9)Daorong Feng, Yan Tang, Hyokjoon Kwon, Haihong Zong,   Meredith Hawkins, Richard N. Kitsis and Jeffrey E. Pessin. High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation. Diabetes 2011 Aug; 60(8):2134-43

(10)Ping Huang, Oladapo Yeku, Haihong Zong, Jeffery E. Pessin Michael A Frohman. Phosphatidylinositol 4-Phosphate 5-Kinase a deficiency alters dynamics of glucose- stimulated insulin secretion and protects against Type II diabetes and obesity in mice. Diabetes. 2011 Feb; 60(2):454-63

(11)Ling Li, Yan Yang,         Gangyi Yang, Chunming Li, Mengliu Yang, Hua Liu and  Haihong Zong. The role of JAZF1 on Lipid metabolism and related genes in virto. Metabolism. 2011 Apr; 60(4):523-30

(12)Maria D’Apolito, Xueliang Du, Haihong Zong, Alessandra Catucci, Luigi Maiuri, Tiziana Trivisano, Massimo Pettoello-Mantovani, Angelo Campanozzi, Valeria Raia, Jeffrey E. Pessin, Michael Brownlee and Ida Giardino. Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. J Clin Invest. 2010; 120(1):203–213

(13)Haihong Zong , Cheng-Chun Wang, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Wanjin Hong and Jeffrey E. Pessin. Enhanced Energy Expenditure, Glucose Utilization And Insulin Sensitivity In VAMP8 Null Mice. Diabetes 2011 Jan; 60(2):454-63(PMCID: PMC3012186)

(14) Mengliu Yang, Gangyi Yang, Dong Jun, Liu Yang, Haihong Zong, Hua Liu, Li L. Elevated plasma levels of chemerin in newly diagnosed type2 diabetes mellitus with hypertension. J investing Med. 2010 Oct: 58(7): 883-6

(15)Ke Li, Ling Li, Mengliu Yang, Haihong Zong, Hua Liu and Gangyi Yang. Effects of rosiglitazone on fasting plasma fibroblast growth factor-21 levels in patients with type 2 diabetes mellitus. Eur J Endocrinol   2009 Sep;161(3):391-5.

(16)Sun Qin, Li Ling, Li Renzhe, Yang Mengliu, Liu Hua, Michael J. Nowicki c, Haihong

Zong,    Jun Xu, Gangyi Yang. Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats. Ann Med. 2009; 41(4): 311-20.

(17)Séverine Groh, Haihong Zong, Matthew M. Goddeeris, David Venzke, Connie S. Lebakken, Jeffrey E. Pessin, and Kevin P. Campbell. The adipose dystrophin glycoprotein complex: implications for metabolic defects in muscular dystrophies. JBC 2009 Jul, 17; 284(29): 19178-82

(18)Haihong Zong, Claire Bastie, Reinhard Fassler, Kevin Campbell and Jeffrey E. Pessin. Insulin Resistance in Striated Muscle Specific Integrin Beta1 Receptor Subunit Knockout Mice. JBC 2009 Feb 13; 284(7): 4679-88

(19)Claire Bastie, Haihong Zong, Jun Xu, Bhavin Busa, Stefan Judex, Irwin J. Kurland, and Jeffrey E. Pessin.             A novel role for the Src Kinase Family Member Fyn in the integrative metabolic regulation of peripheral tissue fatty acid oxidation. Cell Metab. 2007 May; 5(5): 371-81.

(20)Richard M. Reznick, Haihong Zong, Ji Li, Katsutaro Morino, Irene K. Moore, Hannah J. Yu, Zhen-Xiang Liu, Lawrence H. Young, and Gerald I. Shulman. Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis.          Cell Metab. 2007; 5(2):151

(21)Haihong Zong, JianMing Ren, Lawrence H. Young, Marc Pypaert, James Mu, Morris J Birnbaum and Gerald I. Shulman. AMP Kinase is required for Mitochondrial Biogenesis in Skeletal Muscle in Response to Chronic Energy Deprivation. PNAS. 2002 Dec 10; 99(25): 15983-15987.

(22)Chunli Yu, Yan Chen, Haihong Zong and Gerald I Shulman. Mechanism by which Fatty acids Inhibit Insulin Activation of IRS-1 Associated Phosphatidytlinostol

3-kinsae activate in muscle. JBC. 2002 Dec 27; 277(52): 50230-6.

(23)Jason K.Kim Ariel Zisman, Haihong Zong, and Gerald I Shulman. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. JCI 2001. 108:153-16







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