T lymphocytes play a central role in the initiation and regulation of the adaptive immune response to antigen, whether foreign or native. The outcome of T cell engagement of antigen is determined by both positive costimulation and negative coinhibition, generated mainly by the interaction between the B7 ligand family and their receptor CD28 family. We have recently discovered new members of the T cell costimulatory/coinhibitory B7 family and CD28 family, including B7x, HHLA2 and TMIGD2, and are using a variety of experimental approaches (gene knock-out mice, transgenic mice, monoclonal antibodies,crystal structure, etc) to understand how new B7/CD28 family members regulate T cell activation and tolerance. Current emphasis in the lab is placed in the following areas: 1) Novel drugs development: Translational medicine of T cell costimulation and coinhibition; 2) In vivo functions of new B7/CD28 pathways; 3) Human cancer-associated new B7/CD28 pathways and cancer immunotherapy; 4) Roles of new B7/CD28 pathways in autoimmune diseases and immunotherapy; 5) Relationship between new B7/CD28 pathways and infection; 6) Functional and structural characterization of new members of the immunoglobulin superfamily.
Our goal is to elucidate the mechanisms by which costimulation and coinhibition regulate T cells in peripheral non-lymphoid organs, and to translate the lessons learned in these studies towards developing new therapeutic strategies for immune-mediated diseases such as cancers, autoimmune disorders, infectious diseases, and transplantation rejection. Our research have won extensive attention from biopharmaceutical industry including some of the biggest drug companies.
T lymphocyte, Immunotherapy, Co-inhibition, Cancer immunotherapy, Autoimmunity, Infection, Organ transplantation.
More Information About Dr. Xingxing Zang
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 405A
Bronx, NY 10461