Faculty Profile

Dr. Xingxing Zang, Ph.D.

Xingxing Zang, Ph.D.

Professor, Department of Microbiology & Immunology

Professor, Department of Medicine (Oncology)

Professor, Department of Urology

Louis Goldstein Swan Chair in Women's Cancer Research

Areas of Research: * New T cell immune checkpoints * Cancer immunotherapy * Autoimmune diseases and immunotherapy * Metabolic diseases and immunotherapy * Infection and vaccines

Professional Interests

T lymphocytes play a central role in the initiation and regulation of the adaptive immune response to antigen, whether foreign or native. The outcome of T cell engagement of antigen is determined by both positive costimulation and negative coinhibition, generated mainly by the interaction between the B7 ligand family and their receptor CD28 family. We have recently discovered new members of the T cell costimulatory/coinhibitory B7 family and CD28 family including B7x, HHLA2 and TMIGD2, and have contributed to other immune checkpoints ICOS, PD-L1/PD-1, B7-H3, Tim-3, BTNL2, etc. We are using a variety of experimental approaches (gene knock-out mice, transgenic mice, monoclonal antibodies,crystal structure, patients samples, etc) to understand how new immune checkpoints regulate T cell activation and tolerance. Current emphasis in the lab is placed in the following areas: 1) Novel drugs development: Translational medicine of new immune checkpoints; 2) In vivo functions of new immune checkpoint pathways; 3) Human cancer-associated new B7/CD28 pathways and cancer immunotherapy; 4) Roles of new immune checkpoint pathways in autoimmune diseases/metabolic diseases and immunotherapy; 5)  Relationship between new B7/CD28 pathways and infection; 6) Functional and structural characterization of new members of the immunoglobulin superfamily. 

Our goal is to elucidate the mechanisms by which new immune checkpoints regulate T cells in peripheral non-lymphoid organs, and to translate the lessons learned in these studies towards developing new therapeutic strategies for cancers, autoimmune disorders, metabolic diseases, infectious diseases, and transplantation rejection. Our research have won extensive attention from biopharmaceutical industry and ventures.

Since 2008 the lab has mentored total 31 trainees of MD-PhD or PhD students, postdoctoral fellows, clinical fellows, and visiting scientists. Many of trainees have subsequently developed independent careers in academic universities, medical centers, biopharmaceutical industry, and US government.

Keywords:

T lymphocyte, Immunotherapy, Co-inhibition, Cancer immunotherapy, Autoimmunity, Infection, Organ transplantation.

More Information About Dr. Xingxing Zang

The Zang Immune Checkpoint and Immunotherapy Lab

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 405A
Bronx, NY 10461

Tel: 718.430.4155
Fax: 718.430.8711

Research Information